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Protein phosphatases are a group of enzymes responsible for the dephosphorylation of various proteins and enzymes in a cell. This role is an extremely important one since protein phosphorylation and dephosphorylation is required for the regulation of a large number of cellular activities. Classification of Protein Phosphatases Analysis/Technology: Cell and Molecular Imaging Technology, Assay of Protein Phosphatases, MS and MNR, Genomics/Proteomics, cDNA Microarray Analysis Cellular Regulation: Substrates, Inhibitors, Regulation, Protein-Protein Interaction Biological Function: Antisense Studies, Transgenic and Knockout Animal Models in Vivo, Therapeutic Approaches
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The progress in molecular biology moved the center of interest from cellular calcium homeostasis and excitotoxicity to apoptosis, neurotrophic factors, NO and peroxynitrite, intracellular signaling, mitochondrial degeneration, inflammatory mechanisms, gene expression and gene therapy. This work discusses these topics and more.