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In this special 20th anniversary issue of Sleep Medicine Clinics, guest editors Drs. Robert Joseph Thomas and Meir H. Kryger bring their considerable expertise to the topic of the Future of Sleep Disorders. Science, innovation, technology, and public and scientific interest all contribute greatly to the future of this fast-changing field. This issue seeks to report on, demystify, and predict the near-future possibilities in sleep medicine, in the expectation that sleep medicine will become increasingly personalized and will better bridge the gap between science and practice.