In the eight years since the publication of Volume 63 of Progress in Brain Research, on this subject, developments in the research field have been very fast. For example, receptor physiology and pharmacology is now an intensively studied field, and the excitotoxic hypothesis of cell death is commonly accepted. Furthermore, it is recognized that ischemia and other insults give rise to a sustained depression of overall protein synthesis, yet lead to the expression of dormant genes and to synthesis of new proteins.In view of this development, this volume focusses on the cellular and molecular aspects of ischemic brain damage. The book will be of great value to all those interested in the pathophysiology of ischemic and traumatic brain damage.

The topic "Cerebrovascular Transport Mechanisms" was chosen by the General Couneil of the International Society of Neuropathology as one of the four main symposia at the IX International Congress of Neuropathology, September 1982 in Vienna. The chairmen of the symposium were asked to structure a program which would cover the reeent devel- opments in this field and which could serve as a background for free communications, relevant to this topic, submitted by the participants of the Congress. Cerebrovascular transport mechanisms refleet the main function of the blood-brain barrier in providing optimaI, homeostatically regulated, biochemical environment for the brain. It is obvious that disturbanees of this function may play a significant role in patho- physiology of various brain disorders.Since the elucidation of the complex blood-brain barrier phenomenon, consisting of various "barrier systems", necessarily requires applica- tion of multidisciplinary approaches, the program of this symposium was structured by evaluation of ultrastructural, cytochemical, physiological, biochemical, pathophysiological and therapeutic aspects of the blood-brain barrier by invited, recognized experts in respec- tive areas. As aresult, this volume of the proceedings of the symposium attempts to summarize much of today's knowledge on cerebrovascular transport mechanisms in health and disease, and is supplemented by the abstracts of free communications dealing with the most reeent research in this field. We hope that this volume wil1 serve both as an introduction and a reference book, and that it wil1 stimulate further research.

Dr. Kaufmann and I wish to welcome you here in Schloss Auel to this second symposium on brain and heart infarct. We have chosen this lovely castle because I am always dissatisfied with meetings in great hotels in cities, where we rush to and from the meeting rooms. I had such an experience overseas just 3 weeks ago from 8 o''clock in the morning until 10 o''clock at night. We want you to feel some of the wonderful atmosphere of the Bergisches La~d. Moreover, we wanted like you to enjoy a bit of the spirit of the Rhein valley and the 2000-year-old city of Cologne, even at the expense of losing a few hours of discus­ sion; though this may be a quantitative loss, we feel sure that the environment of this city will stimulate our discussions. Two years ago we gathered here in Schloss Auel for the first time, attempting to conduct a discussion between neurologists and cardiologists on the similarities and dissimilarities of circulatory disorders of the brain and heart. We are happy to continue this discussi?n in the days to come.

Dr. Kaufmann and I wish to welcome you here in Schloss Auel to this second symposium on brain and heart infarct. We have chosen this lovely castle because I am always dissatisfied with meetings in great hotels in cities, where we rush to and from the meeting rooms. I had such an experience overseas just 3 weeks ago from 8 o'clock in the morning until 10 o'clock at night. We want you to feel some of the wonderful atmosphere of the Bergisches La~d. Moreover, we wanted like you to enjoy a bit of the spirit of the Rhein valley and the 2000-year-old city of Cologne, even at the expense of losing a few hours of discus­ sion; though this may be a quantitative loss, we feel sure that the environment of this city will stimulate our discussions. Two years ago we gathered here in Schloss Auel for the first time, attempting to conduct a discussion between neurologists and cardiologists on the similarities and dissimilarities of circulatory disorders of the brain and heart. We are happy to continue this discussi?n in the days to come.

In the eight years since the publication of Volume 63 of Progress in Brain Research, on this subject, developments in the research field have been very fast. For example, receptor physiology and pharmacology is now an intensively studied field, and the excitotoxic hypothesis of cell death is commonly accepted. Furthermore, it is recognized that ischemia and other insults give rise to a sustained depression of overall protein synthesis, yet lead to the expression of dormant genes and to synthesis of new proteins.In view of this development, this volume focusses on the cellular and molecular aspects of ischemic brain damage. The book will be of great value to all those interested in the pathophysiology of ischemic and traumatic brain damage.

The topic "Cerebrovascular Transport Mechanisms" was chosen by the General Couneil of the International Society of Neuropathology as one of the four main symposia at the IX International Congress of Neuropathology, September 1982 in Vienna. The chairmen of the symposium were asked to structure a program which would cover the reeent devel- opments in this field and which could serve as a background for free communications, relevant to this topic, submitted by the participants of the Congress. Cerebrovascular transport mechanisms refleet the main function of the blood-brain barrier in providing optimaI, homeostatically regulated, biochemical environment for the brain. It is obvious that disturbanees of this function may play a significant role in patho- physiology of various brain disorders.Since the elucidation of the complex blood-brain barrier phenomenon, consisting of various "barrier systems", necessarily requires applica- tion of multidisciplinary approaches, the program of this symposium was structured by evaluation of ultrastructural, cytochemical, physiological, biochemical, pathophysiological and therapeutic aspects of the blood-brain barrier by invited, recognized experts in respec- tive areas. As aresult, this volume of the proceedings of the symposium attempts to summarize much of today's knowledge on cerebrovascular transport mechanisms in health and disease, and is supplemented by the abstracts of free communications dealing with the most reeent research in this field. We hope that this volume wil1 serve both as an introduction and a reference book, and that it wil1 stimulate further research.

Dr. Kaufmann and I wish to welcome you here in Schloss Auel to this second symposium on brain and heart infarct. We have chosen this lovely castle because I am always dissatisfied with meetings in great hotels in cities, where we rush to and from the meeting rooms. I had such an experience overseas just 3 weeks ago from 8 o''clock in the morning until 10 o''clock at night. We want you to feel some of the wonderful atmosphere of the Bergisches La~d. Moreover, we wanted like you to enjoy a bit of the spirit of the Rhein valley and the 2000-year-old city of Cologne, even at the expense of losing a few hours of discus­ sion; though this may be a quantitative loss, we feel sure that the environment of this city will stimulate our discussions. Two years ago we gathered here in Schloss Auel for the first time, attempting to conduct a discussion between neurologists and cardiologists on the similarities and dissimilarities of circulatory disorders of the brain and heart. We are happy to continue this discussi?n in the days to come.

Dr. Kaufmann and I wish to welcome you here in Schloss Auel to this second symposium on brain and heart infarct. We have chosen this lovely castle because I am always dissatisfied with meetings in great hotels in cities, where we rush to and from the meeting rooms. I had such an experience overseas just 3 weeks ago from 8 o'clock in the morning until 10 o'clock at night. We want you to feel some of the wonderful atmosphere of the Bergisches La~d. Moreover, we wanted like you to enjoy a bit of the spirit of the Rhein valley and the 2000-year-old city of Cologne, even at the expense of losing a few hours of discus­ sion; though this may be a quantitative loss, we feel sure that the environment of this city will stimulate our discussions. Two years ago we gathered here in Schloss Auel for the first time, attempting to conduct a discussion between neurologists and cardiologists on the similarities and dissimilarities of circulatory disorders of the brain and heart. We are happy to continue this discussi?n in the days to come.