K. C. Nicolaou – författare

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in ChemistryThis book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins.Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in ChemistryAdopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods.A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.

Fourth volume of a classic in the field of organic synthesis, describing retrosynthetic analysis and total synthesis of important molecules Classics in Total Synthesis IV is a compilation of highly important synthetic methods which lead to complex molecules with valuable properties. From the complex architectures of natural products to the streamlined synthesis of functional molecules, each chapter in Classics in Total Synthesis IV unfolds a unique story. The interplay of mechanisms, reactivity, selectivity, and stereochemical aspects is thoroughly examined, echoing the pedagogical format that has become synonymous with this series. Well-designed graphics are included throughout, and all important parts of the reaction sequences are highlighted. This volume encapsulates the culmination of new methodologies, emerging trends, and a selection of significant total syntheses undertaken from 2009 to 2022 while additionally including two earlier syntheses from 1979 and 1992 for comparison and to highlight the development of organic synthesis over the past decades. The careful balance between historical context, comments on the molecules’ impact to humankind, and the design and execution aspects of each synthesis creates a narrative that is not only clear but also intellectually stimulating. Written by K. C. Nicolaou, Ruocheng Yu and Stephan Rigol, Classics in Total Synthesis IV includes 16 chapters covering: Coupling and rearrangement reactionsRecent advances in nonenzymatic enantioselective cyclizationCycloaddition and annulation reactionsC−H functionalization and transition metal-mediated C−H activationElectroorganic chemistry and visible-light photoredox catalysisHAT-initiated olefin hydrogenation, isomerization, and hydrofunctionalizationJoining its predecessors in weaving together the threads of scientific discovery, challenge, and intellectual pursuit and establishing strong connections with biology and medicine, Classics in Total Synthesis IV is an essential reference for all future and present synthetic organic chemists.