Ka-Chun Wong - Böcker

The advances in biotechnology such as the next generation sequencing technologies are occurring at breathtaking speed. Advances and breakthroughs give competitive advantages to those who are prepared. However, the driving force behind the positive competition is not only limited to the technological advancement, but also to the companion data analytical skills and computational methods which are collectively called computational biology and bioinformatics. Without them, the biotechnology-output data by itself is raw and perhaps meaningless. To raise such awareness, we have collected the state-of-the-art research works in computational biology and bioinformatics with a thematic focus on gene regulation in this book.This book is designed to be self-contained and comprehensive, targeting senior undergraduates and junior graduate students in the related disciplines such as bioinformatics, computational biology, biostatistics, genome science, computer science, applied data mining, applied machine learning, life science, biomedical science, and genetics. In addition, we believe that this book will serve as a useful reference for both bioinformaticians and computational biologists in the post-genomic era.

Chapters provide methods and protocols demonstrating approaches to identify epistasis, genetic epistasis testing, genome-wide epistatic SNP networks, epistasis detection through machine learning, and complex interaction analysis using trigenic synthetic genetic array (t-SGA).

Chapters provide methods and protocols demonstrating approaches to identify epistasis, genetic epistasis testing, genome-wide epistatic SNP networks, epistasis detection through machine learning, and complex interaction analysis using trigenic synthetic genetic array (t-SGA).

The advances in biotechnology such as the next generation sequencing technologies are occurring at breathtaking speed. Advances and breakthroughs give competitive advantages to those who are prepared. However, the driving force behind the positive competition is not only limited to the technological advancement, but also to the companion data analytical skills and computational methods which are collectively called computational biology and bioinformatics. Without them, the biotechnology-output data by itself is raw and perhaps meaningless. To raise such awareness, we have collected the state-of-the-art research works in computational biology and bioinformatics with a thematic focus on gene regulation in this book.This book is designed to be self-contained and comprehensive, targeting senior undergraduates and junior graduate students in the related disciplines such as bioinformatics, computational biology, biostatistics, genome science, computer science, applied data mining, applied machine learning, life science, biomedical science, and genetics. In addition, we believe that this book will serve as a useful reference for both bioinformaticians and computational biologists in the post-genomic era.

This book highlights recent research advances in unsupervised learning using natural computing techniques such as artificial neural networks, evolutionary algorithms, swarm intelligence, artificial immune systems, artificial life, quantum computing, DNA computing, and others. The book also includes information on the use of natural computing techniques for unsupervised learning tasks. It features several trending topics, such as big data scalability, wireless network analysis, engineering optimization, social media, and complex network analytics. It shows how these applications have triggered a number of new natural computing techniques to improve the performance of unsupervised learning methods. With this book, the readers can easily capture new advances in this area with systematic understanding of the scope in depth. Readers can rapidly explore new methods and new applications at the junction between natural computing and unsupervised learning. Includes advances on unsupervised learning using natural computing techniquesReports on topics in emerging areas such as evolutionary multi-objective unsupervised learning Features natural computing techniques such as evolutionary multi-objective algorithms and many-objective swarm intelligence algorithms

This contributed volume explores the emerging intersection between big data analytics and genomics. To reveal novel genomic insights from this data within a reasonable time frame, traditional data analysis methods may not be sufficient or scalable, forcing the need for big data analytics to be developed for genomics.

This contributed volume explores the emerging intersection between big data analytics and genomics. To reveal novel genomic insights from this data within a reasonable time frame, traditional data analysis methods may not be sufficient or scalable, forcing the need for big data analytics to be developed for genomics.