SQL Server 2008 represents a sizable jump forward in scalability, performance, and usability for the DBA, developer, and business intelligence (BI) developer. It is no longer unheard of to have 20-terabyte databases running on a SQL Server. SQL Server administration used to just be the job of a database administrator (DBA), but as SQL Server proliferates throughout smaller companies, many developers have begun to act as administrators as well. Additionally, some of the new features in SQL Server are more developer-centric, and poor configuration of these features can result in poor performance. SQL Server now enables you to manage the policies on hundreds of SQL Servers in your environment as if you were managing a single instance. We've provided a comprehensive, tutorial-based book to get you over the learning curve of how to configure and administer SQL Server 2008. Whether you're an administrator or developer using SQL Server, you can't avoid wearing a DBA hat at some point. Developers often have SQL Server on their own workstations and must provide guidance to the administrator about how they'd like the production configured. Oftentimes, they're responsible for creating the database tables and indexes. Administrators or DBAs support the production servers and often inherit the database from the developer.This book is intended for developers, DBAs, and casual users who hope to administer or may already be administering a SQL Server 2008 system and its business intelligence features, such as Integration Services. This book is a professional book, meaning the authors assume that you know the basics about how to query a SQL Server and have some rudimentary concepts of SQL Server already. For example, this book does not show you how to create a database or walk you through the installation of SQL Server using the wizard. Instead, the author of the installation chapter may provide insight into how to use some of the more advanced concepts of the installation. Although this book does not cover how to query a SQL Server database, it does cover how to tune the queries you've already written.

SQL Server 2008 is how-to guide for experienced DBAs. Tutorial-based, this book will get you over the learning curve of how to configure and administer SQL Server 2008. Whether you''re an administrator or developer using SQL Server, you can''t avoid wearing a DBA hat at some point. The book is loaded with unique tips and workarounds for the most difficult SQL Server admin issues, including managing and monitoring SQL Server, automating administration, security, performance tuning, scaling and replications, clustering, and backup and recovery. A companion website is also available.

SQL Server 2008 is how-to guide for experienced DBAs. Tutorial-based, this book will get you over the learning curve of how to configure and administer SQL Server 2008. Whether you''re an administrator or developer using SQL Server, you can''t avoid wearing a DBA hat at some point. The book is loaded with unique tips and workarounds for the most difficult SQL Server admin issues, including managing and monitoring SQL Server, automating administration, security, performance tuning, scaling and replications, clustering, and backup and recovery. A companion website is also available.

The Sobotta Coloring Book - for understanding and learning anatomy

The Sobotta Coloring Book offers another excellent way to study anatomy, perfectly suited to all those who are looking for an alternative to learning from textbooks.

Dealing with the most important subjects in anatomy, the texts and the simple drawings designed to be colored-in help to understand and revise the most important aspects of human anatomy.

This turns the book into something special: the pictures show the basic anatomical details and the accompanying texts explain the most important aspects of the structures. By actively interacting with the book through coloring-in, the content becomes deeply ingrained in the memory.

The Sobotta Coloring Book provides:

basic anatomical details in over 100 sections, using pictures and text concise accompanying texts for each picture, highlighting important details clinical references, pointing out their practical relevance sketches of sectional planes and perspectives which help with orientation English - Latin Nomenclature

1 Introduction 1. 1 Wnts and Development The f amily of Wnt genes consists of at least 19 members in vertebrates. Wnts ha v e multiple roles during normal development and aetiology of diseases (Wodarz and Nusse 1998; Moon et al. 2002, 2004). These genes encode for glycoproteins that are released in the intercellular space, acting as intercellular mediators (Moon et al. 1997). By binding to their special receptors, the Frizzled (Fz) receptors, they are able to activate at least three different pathways: the canonical, the non-canonical and the Ca 2+ pathway (Fig. 1 ). The Wnt family has been subdivided, using functional assays, into at least two subclasses. In Xenopus , Wnt1, Wnt3a and Wnt8 are able to induce axis duplication in embryos, whereas Wnt4, Wnt5a and Wnt11 cannot (Du et al. 1995). Those Wnts that are able to induce axis duplication are thought to act canonically; those who cannot are thought to act non-canonically. In the literature, therefore, some Wnts are called canonical Wnts while others are called n- cano nical Wnts, suggesting that a special Wnt always activates the same signalling pathway.It is unlikely that the specificity dictating cellular responses resides solely in the Wnt ligands because no one has reported sequence or structural motifs in Wnts that predict their activities in these cellular and embryonic assays.

SQL Server 2008 represents a sizable jump forward in scalability, performance, and usability for the DBA, developer, and business intelligence (BI) developer. It is no longer unheard of to have 20-terabyte databases running on a SQL Server. SQL Server administration used to just be the job of a database administrator (DBA), but as SQL Server proliferates throughout smaller companies, many developers have begun to act as administrators as well. Additionally, some of the new features in SQL Server are more developer-centric, and poor configuration of these features can result in poor performance. SQL Server now enables you to manage the policies on hundreds of SQL Servers in your environment as if you were managing a single instance. We've provided a comprehensive, tutorial-based book to get you over the learning curve of how to configure and administer SQL Server 2008. Whether you're an administrator or developer using SQL Server, you can't avoid wearing a DBA hat at some point. Developers often have SQL Server on their own workstations and must provide guidance to the administrator about how they'd like the production configured. Oftentimes, they're responsible for creating the database tables and indexes. Administrators or DBAs support the production servers and often inherit the database from the developer.This book is intended for developers, DBAs, and casual users who hope to administer or may already be administering a SQL Server 2008 system and its business intelligence features, such as Integration Services. This book is a professional book, meaning the authors assume that you know the basics about how to query a SQL Server and have some rudimentary concepts of SQL Server already. For example, this book does not show you how to create a database or walk you through the installation of SQL Server using the wizard. Instead, the author of the installation chapter may provide insight into how to use some of the more advanced concepts of the installation. Although this book does not cover how to query a SQL Server database, it does cover how to tune the queries you've already written.

SQL Server 2008 is how-to guide for experienced DBAs. Tutorial-based, this book will get you over the learning curve of how to configure and administer SQL Server 2008. Whether you''re an administrator or developer using SQL Server, you can''t avoid wearing a DBA hat at some point. The book is loaded with unique tips and workarounds for the most difficult SQL Server admin issues, including managing and monitoring SQL Server, automating administration, security, performance tuning, scaling and replications, clustering, and backup and recovery. A companion website is also available.

SQL Server 2008 is how-to guide for experienced DBAs. Tutorial-based, this book will get you over the learning curve of how to configure and administer SQL Server 2008. Whether you''re an administrator or developer using SQL Server, you can''t avoid wearing a DBA hat at some point. The book is loaded with unique tips and workarounds for the most difficult SQL Server admin issues, including managing and monitoring SQL Server, automating administration, security, performance tuning, scaling and replications, clustering, and backup and recovery. A companion website is also available.

The Sobotta Coloring Book - for understanding and learning anatomy

The Sobotta Coloring Book offers another excellent way to study anatomy, perfectly suited to all those who are looking for an alternative to learning from textbooks.

Dealing with the most important subjects in anatomy, the texts and the simple drawings designed to be colored-in help to understand and revise the most important aspects of human anatomy.

This turns the book into something special: the pictures show the basic anatomical details and the accompanying texts explain the most important aspects of the structures. By actively interacting with the book through coloring-in, the content becomes deeply ingrained in the memory.

The Sobotta Coloring Book provides:

basic anatomical details in over 100 sections, using pictures and text concise accompanying texts for each picture, highlighting important details clinical references, pointing out their practical relevance sketches of sectional planes and perspectives which help with orientation English - Latin Nomenclature

1 Introduction 1. 1 Wnts and Development The f amily of Wnt genes consists of at least 19 members in vertebrates. Wnts ha v e multiple roles during normal development and aetiology of diseases (Wodarz and Nusse 1998; Moon et al. 2002, 2004). These genes encode for glycoproteins that are released in the intercellular space, acting as intercellular mediators (Moon et al. 1997). By binding to their special receptors, the Frizzled (Fz) receptors, they are able to activate at least three different pathways: the canonical, the non-canonical and the Ca 2+ pathway (Fig. 1 ). The Wnt family has been subdivided, using functional assays, into at least two subclasses. In Xenopus , Wnt1, Wnt3a and Wnt8 are able to induce axis duplication in embryos, whereas Wnt4, Wnt5a and Wnt11 cannot (Du et al. 1995). Those Wnts that are able to induce axis duplication are thought to act canonically; those who cannot are thought to act non-canonically. In the literature, therefore, some Wnts are called canonical Wnts while others are called n- cano nical Wnts, suggesting that a special Wnt always activates the same signalling pathway.It is unlikely that the specificity dictating cellular responses resides solely in the Wnt ligands because no one has reported sequence or structural motifs in Wnts that predict their activities in these cellular and embryonic assays.