Khawaja H. Haider – författare

This book provides a comprehensive review of the advancements in cell-free therapeutic applications, focusing on the biological and biomedical potential of mesenchymal stem cell (MSC)-derived secretome and extracellular vesicles (EVs) in disease treatment and tissue repair. It examines the mechanistic functions of MSC-derived biomolecules and the regulatory landscape shaping their development. The discussion then progresses to innovative strategies for enhancing the MSC secretome through priming techniques, optimizing its biological activity for therapeutic applications. The book examines the application of exosome-based and EV-driven therapies across a broad range of biomedical fields, including neuroscience, cardiology, ophthalmology, gastroenterology, and oncology. Further, it highlights the role of MSC-derived secretome in treating neurocognitive disorders, autoimmune diseases, diabetes complications, and inflammatory conditions, with a special focus on innovations in drug delivery, tissue repair. Additionally, it examines the emerging use of EVs as theranostic tools in cancer therapy and their application in novel treatment strategies for COVID-19. The book also addresses key challenges in transitioning these cell-free therapies from bench to bedside, covering critical aspects such as formulation, large-scale production, regulatory approvals, and clinical implementation.Key Features:1) Explores the biomedical applications of MSC-derived secretome and EVs across different diseases.2) Discusses the biological and therapeutic potential of exosome-based treatments for neurodegenerative, cardiovascular, ophthalmological, and metabolic diseases.3) Examines innovations in extracellular vesicle-based cell-free therapies for targeted tissue repair and disease intervention.4) Reviews the challenges of translating EV-based therapeutics into clinical practice, including regulatory and manufacturing considerations.5) Highlights cutting-edge applications of EVs in oncology, infectious diseases, and theranostics.This book serves as an important resource for researchers and students of biomedical engineering, biotechnology, and stem cell biology.

In this volume, the contributing authors from top labs involved in stem cell theranostics share the latest advances in the field of stem cell research. The book covers many aspects of stem cell-based therapy and the progress made toward stem cell therapy for liver, ocular, and cardiovascular diseases as well as cancer.

In this volume, the contributing authors from top labs involved in stem cell theranostics share the latest advances in the field of stem cell research. The book covers many aspects of stem cell-based therapy and the progress made toward stem cell therapy for liver, ocular, and cardiovascular diseases as well as cancer.

In diesem Band berichten die Autoren aus führenden Labors, die sich mit Stammzelltheranostik beschäftigen, über die neuesten Fortschritte auf dem Gebiet der Stammzellforschung. Das Buch befasst sich mit vielen Aspekten der stammzellbasierten Therapie und den Fortschritten in der Stammzelltherapie bei Leber-, Augen- und Herz-Kreislauf-Erkrankungen sowie bei Krebs. Dieser Band ist eine Fortsetzung der von Prof. Khawaja Husnain Haider bereits herausgegebenen Bücher zur stammzellbasierten Therapienostik. Es ist ein ideales Buch für Forscher, die sich mit der Entwicklung von Arzneimitteln sowie mit regenerativer Medizin und stammzellbasierter Therapie beschäftigen. Die sekundäre Zielgruppe umfasst Medizinstudenten, Ärzte, Zellpharmakologen, die Arzneimittelindustrie und Forscher, die Stammzellen als Ex-vivo-Krankheitsmodelle für die Arzneimittelentwicklung verwenden.

The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes,their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.

The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes,their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.