Kim Lewis - Böcker

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

A delightful paperback version of a much loved picture book classic!Floss lives in the city and loves to go to the park and play ball with the children. But her owner's son is a farmer and needs a new sheepdog, so the border collie moves to a Northumberland farm and must learn how to round up the sheep. Children will love hearing about the rural adventures of Floss in this stunning picture book.

Kids will flock like sheep to Floss the border collieAcclaimed author-illustrator Kim Lewis has created another warm and evocative story that depicts the world of rural children and animals in affectionate detail. Floss has just had puppies, and the children want to know if they can keep one. "Maybe," their father says. "We could use another collie just like Floss to work with the sheep on the farm." But which one? Day after day the children watch the puppies grow, until one day Sam, the littlest, strays into the field. The sheep crowd around him, but instead of flinching, the puppy crouches low and runs, scattering the flock. "Big brave Sam," exclaim the children, racing after him, "just like Floss."

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.

This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.