Leland W. K. Chung – författare
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2 produkter
2 produkter
1 619 kr
Skickas inom 10-15 vardagar
Metastasis to bone is a common event in cancer. However, due to the skeleton's unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases. Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator.The Biology of Skeletal Metastases includes chapters on the following: - basic biology of the metastatic process and the specific biology of skeletal metastasis including tumor targeting to bone; - interactions between the tumor and bone microenvironment and the development of tumor-induced osteoclastic and osteoblastic lesions; - specific effectors of bone metastasis including macrophage inflammatory protein, collagen-I, parathyroid hormone-related protein, receptor activator of nuclear factor kappa B, endothelins, and matrix metalloproteinases. Research methodologies such as animal models of skeletal metastasis are reviewed.Furthermore, developments in clinical aspects of skeletal metastasis including bisphosphonate and gene therapies are addressed in this comprehensive book (including 12 pages of full color illustrations). 'Skeletal metastases are both a common and devastating consequence of a spectrum of cancers. Significant advances have occurred in our understanding of the pathobiology of this process. This text provides a comprehensive review of current investigative findings and their clinical implications.' Steven T. Rosen, M.D. Series Editor
1 657 kr
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Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.