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This biography of Severus, the patriarch of Antioch from 512-518 CE, attributed to his schoolmate Zachariah of Mytilene, gives unique information about life in Mediterranean region in the second half of the 5th century. These two young men from wealthy families became involved with a Christian movement, the "philoponoi," "those devoted to work" who combined asceticism with theological study. The work, originally in Greek, survives only in Syriac, which this volume presents alongside the first English translation of it. It is an important source for studies on Ancient Biography, Late Antiquity, and Early Christianity.