This book constitutes the refereed proceedings of the International Symposium on Bioinformatics Research and Applications, ISBRA 2012, held in Dallas, Texas, USA, in May 2012.The 26 revised full papers presented together with five invited talks were carefully reviewed andselected from 66 submissions. The papers address issues on various aspects of bioinformatics and computational biology and their applications.

This book constitutes the refereed proceedings of the International Symposium on Bioinformatics Research and Applications, ISBRA 2012, held in Dallas, Texas, USA, in May 2012.The 26 revised full papers presented together with five invited talks were carefully reviewed andselected from 66 submissions. The papers address issues on various aspects of bioinformatics and computational biology and their applications.