Liang - Böcker

Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents. Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research. Enhanced by examples with updated research results, the discussion covers such topics as:* The chemistry and biology of epothilones* Vancomycin and other glycopeptide antibiotic derivates* Antitumor and other related activities of Taxol and its analogs* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)* Huperzine A: A natural drug for the treatment of Alzheimer's disease* The medicinal chemistry of ginkgolides from Ginkgo biloba* Recent progress in Calophyllum coumarins as potent anti-HIV agents* Plant-derived anti-HIV agents and analogs* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

Kaiser Permanente has implemented the largest nongovernmental electronic health record in the world, serving more than 8.6 million Kaiser Permanente members. Called KP HealthConnect, its impact on patient care outcomes, efficiency, safety, and patient engagement and satisfaction already is of intense interest throughout the health care industry. In this volume, Louise L. Liang, MD, who led the massive KP HealthConnect implementation, collects lessons learned from the organization's successful deployment strategy and highlights ways in which the new technological tools are changing and improving - the health care provided to patients and the operations and culture of the organization. Advance praise for Connected for Health"Health care transformation requires leadership and innovation. Connected for Health clearly shows there is no shortage of either at Kaiser Permanente. This is a must read for policy makers and practitioners as the lessons are of critical value if we are to achieve quality, affordable care for Americans."—H. Stephen Lieber, president and CEO, Healthcare Information and Management Systems Society"Connected for Health shares what Kaiser Permanente has learned so far in tapping the vast potential of electronic health records to improve care and expand the frontiers of medical research. It is a journey that should be of great interest to policy leaders in the United States and around the world."—Karen Davis, president, The Commonwealth Fund"This book is destined to become an important part of the critical dialogue on what reforming our health care system really means."—James J. Mongan, MD, Professor of Health Care Policy and Social Medicine, Harvard Medical School"Connected for Health shows how KP HealthConnect is facilitating great team-based care, getting quality right every time, getting patients activated, and freeing caregivers to connect as true healers with their patients."—Margaret E. O'Kane, president, National Committee for Quality Assurance"Effective implementation and use of health information technology is critical to improving the quality, safety, and affordability of health care. This book provides a great opportunity for others to learn from Kaiser Permanente's pioneering efforts."—Janet M. Corrigan, president and CEO, National Quality Forum