Louis M. Weiss – författare

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists

Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods, Fourth Edition offers a comprehensive approach and balance between historical research, new developments, and innovative approaches to Toxoplasma gondii research. Completely updated and revised, the new Edition aims to provide a better understanding of the structure, genetic diversity, and population biology of T. gondii. The book details the immunology, molecular, and cellular biology of Toxoplasma gondii combined with new molecular techniques, methods, and resources for working with this pathogen. It also offers the latest information concerning epidemiology, diagnosis, treatment, and prevention of toxoplasmosis.With contributions from leading experts in the field, this is an essential one-stop resource for a wide range of researchers, scientists, and clinicians engaged in the study of T. gondii and toxoplasmosis.Offers contributions from leading experts in the field, including new topics such as One Health and toxoplasmosis in wild and domestic animals, secreted effectors and host cell manipulation, Cryo-electron microscopy (CryoEM), and the identification of subcellular proteome using hyperLOPITIncludes new information on the ultrastructure, genomics, epigenomics, and proteomics of T. gondii genomicsProvides expanded information on the effects of T. gondii and the implication of toxoplasmosis on neurological diseases and psychiatric diseases

Microsporidia: Pathogens of Opportunity provides a systematic overview of the biology of microsporidia. Written by leading experts in the field, the book combines background and basic information on microsporidia with descriptive methods and resources for working with the pathogen.Newly revised and updated for its second edition, Microsporidia will continue to be the standard text reference for these pathogenic protists, and is an indispensable research resource for biologists,physicians and parasitologists.This new edition of this publication provides systematic reviews of the biology of this pathogen by leading experts in the field, and will be combined with descriptions of the methods and resources for working with this pathogen.• Provides a comprehensive summary of literature on microsporidia and microsporidiosis• The long-awaited update to the standard microsporidia reference text The Microsporidia and Microsporidiosis • Written by an international team of authors representing each of the main research groups working on microsporidia• Chapters provide comprehensive overviews of general methodology as well as special techniques related to these organisms

Protozoan parasites compromise an extremely diverse group of eukaryotic life forms. The Phyla Apicomplexa and Microsporidia are obligatory parasites. All Microsporidian parasites are intracellular in host cells and most Apicomplexan parasites live inside of host cells. These two Phyla of protists contain some of the most interesting and diverse groups of parasites infecting vertebrates and invertebrates. Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia will focus on two important Genera of Apicomplexan parasites, Toxoplasma gondii and Sarcocystis species, and the medically important members of the Phylum Microsporida. We have been fortunate in obtaining excellent contributions from many experts in the field. Volumes in the "World Class Parasites" book series are written for researchers, students and scholars who enjoy reading about excellent research on problems of global significance. Each volume focuses on a parasite, or group of parasites, that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. The volumes are intended to supplement more formal texts that cover taxonomy, life cycles, morphology

Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia will focus on two important Genera of Apicomplexan parasites, Toxoplasma gondii and Sarcocystis species, and the medically important members of the Phylum Microsporida. We have been fortunate in obtaining excellent contributions from many experts in the field. Volumes in the "World Class Parasites" book series are written for researchers, students and scholars who enjoy reading about excellent research on problems of global significance. Each volume focuses on a parasite, or group of parasites, that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. The volumes are intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. They integrate vector, pathogen and host biology and celebrate the diversity of approach that comprises modern parasitological research.

This book provides an up-to-date overview on the biology of microsporidia, focusing on areas where significant progress has been made in recent years. In particular, our understanding of the evolutionary position and the role of genome reduction in the biology of these enigmatic intracellular pathogens is discussed. This book also offers important updates on the mechanisms used by these organisms to modify the host cell biology of mammals, insects, nematodes, and aquatic animals, as well as the mechanisms controlling infection and host specificity. Readers gain a detailed overview of the structure and function of the polar tube, the unique invasion apparatus of microsporidia, as well as the physics and dynamics of spore firing. Particular attention is given to chronic infections in mammals caused by microsporidia, as well as common immune responses.Written by an international team of authors representing the main research groups working on microsporidianbiology, this book is a valuable resource for health management professionals, experienced microbiologists, and early career scientist alike who want to learn more about these fascinating parasites. The ideas and latest finding covered in this book contribute to UN Sustainable Development Goal 3: Good Health and Well-Being.  Chapter “Impact of Genome Reduction in Microsporidia“ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.