Louxin Zhang - Böcker

Biomolecular sequence comparison is the origin of bioinformatics. This book gives a complete in-depth treatment of the study of sequence comparison.A comprehensive introduction is followed by a focus on alignment algorithms and techniques, proceeded by a discussion of the theory. The book examines alignment methods and techniques, features a new issue of sequence comparison - the spaced seed technique, addresses several new flexible strategies for coping with various scoring schemes, and covers the theory on the significance of high-scoring segment pairs between two unalignment sequences. Useful appendices on basic concepts in molecular biology, primer in statistics and software for sequence alignment are included in this reader-friendly text, as well as chapter-ending exercise and research questionsA state-of-the-art study of sequence alignment and homology search, this is an ideal reference for advanced students studying bioinformatics and will appeal to biologists who wish to know how to use homology search tools.

Biomolecular sequence comparison is the origin of bioinformatics. This book gives a complete in-depth treatment of the study of sequence comparison.A comprehensive introduction is followed by a focus on alignment algorithms and techniques, proceeded by a discussion of the theory. The book examines alignment methods and techniques, features a new issue of sequence comparison - the spaced seed technique, addresses several new flexible strategies for coping with various scoring schemes, and covers the theory on the significance of high-scoring segment pairs between two unalignment sequences. Useful appendices on basic concepts in molecular biology, primer in statistics and software for sequence alignment are included in this reader-friendly text, as well as chapter-ending exercise and research questionsA state-of-the-art study of sequence alignment and homology search, this is an ideal reference for advanced students studying bioinformatics and will appeal to biologists who wish to know how to use homology search tools.

The abstract and papers in this volume were presented at the Eighth Annual International Computing and Combinatorics Conference (COCOON 2002), held on August 15-17 in Singapore. The topics cover various aspects of theoretical computer science and combinatorics related to computing. Submissionstotheconferencethisyearwereconductedelectronically. The60 papers were selected for presentation from a total of 106 submitted papers from Australia (6), Canada (3), China (6), Germany (9), India (5), Japan (11), Korea (10), Singapore (5), Taiwan (8), United States (29), and 11 other countries and regions (14). The papers were evaluated by an international program comm- tee consisting of Mikhail Atallah, Jik Chang, Tim Ting Chen, Siu-Wing Cheng, Omer Egecioglu, Fan Chung Graham, Susanne Hambrusch, Sorin Istrail, S- path Kannan, Ming-Yang Kao, Shlomo Moran, Koji Nakano, Takao Nishizeki, Steve Olariu, Gheorghe Paun, Pandu Rangan, Sartaj Sahni, Arto Salomaa, Igor Shparlinski, Janos Simon, Paul Spirakis, Chung Piaw Teo, Jan van Leeuwen, Paul Vitanyi, Peter Widmayer, and Hsu-Chun Yen. It is expected that most of the accepted papers will appear in a more complete form in scienti?c journals.In addition to the contributed papers, three invited lectures were presented by Eugene W. Myers, Sartaj Sahni, and Arto Salomaa. We wish to thank all who have made this meeting possible: the authors for submitting papers, the program committee members and external referees (listed in the proceedings) for their excellent work, and the three invited spe- ers.