At last his students and colleagues, his friends and his friendly critics, his fellow-scientist and fellow-philosophers, have the works of Milic Capek before them in one volume, aside from his books of course. Now the development of his interests and his thoughts, always led centrally by his concern to understand 'the philosophical impact of contemporary physics', becomes clear. In the nearly 90 essays and papers, and in his book on the philosophical impact as well as his classical restatement of process philosophy in his Bergson and Modern Physics, Professor Capek establishes one of the fundamental alternatives to the comprehension of human experience, and thereby of the world. Capek is certainly to be seen with respect and admiration, for he has dealt with the deepest and toughest of scientific as well as metaphysical problems: his major efforts in the philosophy of mind focussed upon the time of experience, and in the philosophy of physics focussed upon continuity, causality and again the temporal, now in the world-picture.

Milic Capek has devoted his scholarship to the history and philosophy of modern physics. With impeccable care, he has mastered the epistemologi­ cal and scientific developments by working through the papers, treatises, correspondence of physicists since Kant, and likewise he has put his learning and critical skill into the related philosophical literature. Coming from his original scientific career with a philosophy doctorate from the Charles University in Prague, Capek has ranged beyond a narrowly defined philosophy of physics into general epistemology of the natural sciences and to the full historical evolution of these matters. He has ex­ pounded his views on these matters in a number of articles and, systema­ tically, in his book The Philosophical Impact of Contemporary PhYSiCS, published in 1961 and reprinted with two new appendices in 1969. His particular gift for many of his readers and students lies in the great period from the mid-nineteenth century through the foundations of the physics and philosophy of the twentieth, and within this spectacular time, Profes­ sor Capek has become a principal expositor and sympathetic critic of the philosophy of Henri Bergson. He joins a distinguished group of scholars -physicists and philosophers -who have been stimulated to some of their most profound and imaginative thought by Bergson's metaphysical and psychological work: Cassirer, Meyerson, de Broglie, Metz, Jankelevitch, Zawirski, and in recent years, Costa de Beauregard, Watanabe, Blanche, and others.

At last his students and colleagues, his friends and his friendly critics, his fellow-scientist and fellow-philosophers, have the works of Milic Capek before them in one volume, aside from his books of course. Now the development of his interests and his thoughts, always led centrally by his concern to understand ''the philosophical impact of contemporary physics'', becomes clear. In the nearly 90 essays and papers, and in his book on the philosophical impact as well as his classical restatement of process philosophy in his Bergson and Modern Physics, Professor Capek establishes one of the fundamental alternatives to the comprehension of human experience, and thereby of the world. Capek is certainly to be seen with respect and admiration, for he has dealt with the deepest and toughest of scientific as well as metaphysical problems: his major efforts in the philosophy of mind focussed upon the time of experience, and in the philosophy of physics focussed upon continuity, causality and again the temporal, now in the world-picture.

Milic Capek has devoted his scholarship to the history and philosophy of modern physics. With impeccable care, he has mastered the epistemologi­ cal and scientific developments by working through the papers, treatises, correspondence of physicists since Kant, and likewise he has put his learning and critical skill into the related philosophical literature. Coming from his original scientific career with a philosophy doctorate from the Charles University in Prague, Capek has ranged beyond a narrowly defined philosophy of physics into general epistemology of the natural sciences and to the full historical evolution of these matters. He has ex­ pounded his views on these matters in a number of articles and, systema­ tically, in his book The Philosophical Impact of Contemporary PhYSiCS, published in 1961 and reprinted with two new appendices in 1969. His particular gift for many of his readers and students lies in the great period from the mid-nineteenth century through the foundations of the physics and philosophy of the twentieth, and within this spectacular time, Profes­ sor Capek has become a principal expositor and sympathetic critic of the philosophy of Henri Bergson. He joins a distinguished group of scholars -physicists and philosophers -who have been stimulated to some of their most profound and imaginative thought by Bergson''s metaphysical and psychological work: Cassirer, Meyerson, de Broglie, Metz, Jankelevitch, Zawirski, and in recent years, Costa de Beauregard, Watanabe, Blanche, and others.

Milic Capek has devoted his scholarship to the history and philosophy of modern physics. With impeccable care, he has mastered the epistemologi­ cal and scientific developments by working through the papers, treatises, correspondence of physicists since Kant, and likewise he has put his learning and critical skill into the related philosophical literature. Coming from his original scientific career with a philosophy doctorate from the Charles University in Prague, Capek has ranged beyond a narrowly defined philosophy of physics into general epistemology of the natural sciences and to the full historical evolution of these matters. He has ex­ pounded his views on these matters in a number of articles and, systema­ tically, in his book The Philosophical Impact of Contemporary PhYSiCS, published in 1961 and reprinted with two new appendices in 1969. His particular gift for many of his readers and students lies in the great period from the mid-nineteenth century through the foundations of the physics and philosophy of the twentieth, and within this spectacular time, Profes­ sor Capek has become a principal expositor and sympathetic critic of the philosophy of Henri Bergson. He joins a distinguished group of scholars -physicists and philosophers -who have been stimulated to some of their most profound and imaginative thought by Bergson's metaphysical and psychological work: Cassirer, Meyerson, de Broglie, Metz, Jankelevitch, Zawirski, and in recent years, Costa de Beauregard, Watanabe, Blanche, and others.

At last his students and colleagues, his friends and his friendly critics, his fellow-scientist and fellow-philosophers, have the works of Milic Capek before them in one volume, aside from his books of course. Now the development of his interests and his thoughts, always led centrally by his concern to understand 'the philosophical impact of contemporary physics', becomes clear. In the nearly 90 essays and papers, and in his book on the philosophical impact as well as his classical restatement of process philosophy in his Bergson and Modern Physics, Professor Capek establishes one of the fundamental alternatives to the comprehension of human experience, and thereby of the world. Capek is certainly to be seen with respect and admiration, for he has dealt with the deepest and toughest of scientific as well as metaphysical problems: his major efforts in the philosophy of mind focussed upon the time of experience, and in the philosophy of physics focussed upon continuity, causality and again the temporal, now in the world-picture.

Fundamental studies of steroid compounds have begun approximately thirty years ago with the solution of structures of cholesterol and bile acids. This field has been receiving more attention when the structures of the principal steroid hormones, aglycones of heart glycosides, sapogenins, steroid alkaloids, toad poisons have been established. An intensive interest in these derivatives of cyc1opentanoperhydrophe­ nanthrene was determined especially by practical viewpoints, notably by attempts to prepare by synthetical economical procedures a series of steroid hormones and their biologically active derivatives, further by theoretical viewpoints. Biochemistry of steroids was developing in its beginnings by studies of meta­ bolites of steroid hormones in animal organism and soon has brought a number of practical results that could be used also in medical diagnostics. Considerably later, the metabolism of steroid compounds was followed also in microorganisms, again in connection with the practical problem to aid to economical syntheses of some steroid hormones. Two names are of primary importance for the pioneer works in microbial transformations of steroids, that of the Italian worker L. MAMOLI who first realized the microbial biosynthesis of testosterone from dehydroepiandro­ sterone, and of the American chemist and microbiologist D. H. PETERSON, who has contributed by his fundamental experiments in microbial hydroxylation of steroids to the position eleven, especially to the synthesis of cortisone. Microbial transforma­ tions of steroids nowadays offer a valuable tool in the preparation of series otherwise difficultly accessible steroid compounds.

At last his students and colleagues, his friends and his friendly critics, his fellow-scientist and fellow-philosophers, have the works of Milic Capek before them in one volume, aside from his books of course. Now the development of his interests and his thoughts, always led centrally by his concern to understand 'the philosophical impact of contemporary physics', becomes clear. In the nearly 90 essays and papers, and in his book on the philosophical impact as well as his classical restatement of process philosophy in his Bergson and Modern Physics, Professor Capek establishes one of the fundamental alternatives to the comprehension of human experience, and thereby of the world. Capek is certainly to be seen with respect and admiration, for he has dealt with the deepest and toughest of scientific as well as metaphysical problems: his major efforts in the philosophy of mind focussed upon the time of experience, and in the philosophy of physics focussed upon continuity, causality and again the temporal, now in the world-picture.

Milic Capek has devoted his scholarship to the history and philosophy of modern physics. With impeccable care, he has mastered the epistemologi­ cal and scientific developments by working through the papers, treatises, correspondence of physicists since Kant, and likewise he has put his learning and critical skill into the related philosophical literature. Coming from his original scientific career with a philosophy doctorate from the Charles University in Prague, Capek has ranged beyond a narrowly defined philosophy of physics into general epistemology of the natural sciences and to the full historical evolution of these matters. He has ex­ pounded his views on these matters in a number of articles and, systema­ tically, in his book The Philosophical Impact of Contemporary PhYSiCS, published in 1961 and reprinted with two new appendices in 1969. His particular gift for many of his readers and students lies in the great period from the mid-nineteenth century through the foundations of the physics and philosophy of the twentieth, and within this spectacular time, Profes­ sor Capek has become a principal expositor and sympathetic critic of the philosophy of Henri Bergson. He joins a distinguished group of scholars -physicists and philosophers -who have been stimulated to some of their most profound and imaginative thought by Bergson's metaphysical and psychological work: Cassirer, Meyerson, de Broglie, Metz, Jankelevitch, Zawirski, and in recent years, Costa de Beauregard, Watanabe, Blanche, and others.

At last his students and colleagues, his friends and his friendly critics, his fellow-scientist and fellow-philosophers, have the works of Milic Capek before them in one volume, aside from his books of course. Now the development of his interests and his thoughts, always led centrally by his concern to understand ''the philosophical impact of contemporary physics'', becomes clear. In the nearly 90 essays and papers, and in his book on the philosophical impact as well as his classical restatement of process philosophy in his Bergson and Modern Physics, Professor Capek establishes one of the fundamental alternatives to the comprehension of human experience, and thereby of the world. Capek is certainly to be seen with respect and admiration, for he has dealt with the deepest and toughest of scientific as well as metaphysical problems: his major efforts in the philosophy of mind focussed upon the time of experience, and in the philosophy of physics focussed upon continuity, causality and again the temporal, now in the world-picture.

Milic Capek has devoted his scholarship to the history and philosophy of modern physics. With impeccable care, he has mastered the epistemologi­ cal and scientific developments by working through the papers, treatises, correspondence of physicists since Kant, and likewise he has put his learning and critical skill into the related philosophical literature. Coming from his original scientific career with a philosophy doctorate from the Charles University in Prague, Capek has ranged beyond a narrowly defined philosophy of physics into general epistemology of the natural sciences and to the full historical evolution of these matters. He has ex­ pounded his views on these matters in a number of articles and, systema­ tically, in his book The Philosophical Impact of Contemporary PhYSiCS, published in 1961 and reprinted with two new appendices in 1969. His particular gift for many of his readers and students lies in the great period from the mid-nineteenth century through the foundations of the physics and philosophy of the twentieth, and within this spectacular time, Profes­ sor Capek has become a principal expositor and sympathetic critic of the philosophy of Henri Bergson. He joins a distinguished group of scholars -physicists and philosophers -who have been stimulated to some of their most profound and imaginative thought by Bergson''s metaphysical and psychological work: Cassirer, Meyerson, de Broglie, Metz, Jankelevitch, Zawirski, and in recent years, Costa de Beauregard, Watanabe, Blanche, and others.

Milic Capek has devoted his scholarship to the history and philosophy of modern physics. With impeccable care, he has mastered the epistemologi­ cal and scientific developments by working through the papers, treatises, correspondence of physicists since Kant, and likewise he has put his learning and critical skill into the related philosophical literature. Coming from his original scientific career with a philosophy doctorate from the Charles University in Prague, Capek has ranged beyond a narrowly defined philosophy of physics into general epistemology of the natural sciences and to the full historical evolution of these matters. He has ex­ pounded his views on these matters in a number of articles and, systema­ tically, in his book The Philosophical Impact of Contemporary PhYSiCS, published in 1961 and reprinted with two new appendices in 1969. His particular gift for many of his readers and students lies in the great period from the mid-nineteenth century through the foundations of the physics and philosophy of the twentieth, and within this spectacular time, Profes­ sor Capek has become a principal expositor and sympathetic critic of the philosophy of Henri Bergson. He joins a distinguished group of scholars -physicists and philosophers -who have been stimulated to some of their most profound and imaginative thought by Bergson's metaphysical and psychological work: Cassirer, Meyerson, de Broglie, Metz, Jankelevitch, Zawirski, and in recent years, Costa de Beauregard, Watanabe, Blanche, and others.

At last his students and colleagues, his friends and his friendly critics, his fellow-scientist and fellow-philosophers, have the works of Milic Capek before them in one volume, aside from his books of course. Now the development of his interests and his thoughts, always led centrally by his concern to understand 'the philosophical impact of contemporary physics', becomes clear. In the nearly 90 essays and papers, and in his book on the philosophical impact as well as his classical restatement of process philosophy in his Bergson and Modern Physics, Professor Capek establishes one of the fundamental alternatives to the comprehension of human experience, and thereby of the world. Capek is certainly to be seen with respect and admiration, for he has dealt with the deepest and toughest of scientific as well as metaphysical problems: his major efforts in the philosophy of mind focussed upon the time of experience, and in the philosophy of physics focussed upon continuity, causality and again the temporal, now in the world-picture.

Fundamental studies of steroid compounds have begun approximately thirty years ago with the solution of structures of cholesterol and bile acids. This field has been receiving more attention when the structures of the principal steroid hormones, aglycones of heart glycosides, sapogenins, steroid alkaloids, toad poisons have been established. An intensive interest in these derivatives of cyc1opentanoperhydrophe­ nanthrene was determined especially by practical viewpoints, notably by attempts to prepare by synthetical economical procedures a series of steroid hormones and their biologically active derivatives, further by theoretical viewpoints. Biochemistry of steroids was developing in its beginnings by studies of meta­ bolites of steroid hormones in animal organism and soon has brought a number of practical results that could be used also in medical diagnostics. Considerably later, the metabolism of steroid compounds was followed also in microorganisms, again in connection with the practical problem to aid to economical syntheses of some steroid hormones. Two names are of primary importance for the pioneer works in microbial transformations of steroids, that of the Italian worker L. MAMOLI who first realized the microbial biosynthesis of testosterone from dehydroepiandro­ sterone, and of the American chemist and microbiologist D. H. PETERSON, who has contributed by his fundamental experiments in microbial hydroxylation of steroids to the position eleven, especially to the synthesis of cortisone. Microbial transforma­ tions of steroids nowadays offer a valuable tool in the preparation of series otherwise difficultly accessible steroid compounds.