M. James C. Crabbe – författare

The assimilation of computational methods into the life sciences has played an important role in advancing biological research. From sequencing genomes to discovering motifs in large collections of functionally equivalent sequences of nucleic acids and proteins, the value of powerful computational tools has become abundantly clear. The Compact Handbook of Computational Biology describes the foundational concepts, techniques, and challenges of biomolecular sequence analysis, biopolymer structure analysis and prediction, genomics, and molecular evolution.Comprising contributions from renowned scientists, many of whom pioneered current methodologies, the Compact Handbook of Computational Biology offers interdisciplinary and authoritative coverage of methods for analysis of nucleic acid and protein sequences and structures, definition and detection of motifs in nucleic acid and protein sequences, protein structure prediction, and discrete modeling of biopolymers. Specific computational topics include computer-assisted research on protein folding, computer-assisted studies of DNA-protein interactions, computer-assisted genomics, proteomics, and comparative genomics, and computer-assisted studies of genome evolution at the molecular (DNA) level.Offering a survey of specific algorithms that have proven successful in molecular biology, genomics, structural biology, and bioinformatics, this invaluable handbook is an authoritative source covering terminology, software, and applications of computational biology.

Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.

Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux''s concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.

Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux''s concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.

Written by a dynamic team of highly regarded and experienced scientists, many of whom pioneered current methodologies in computer-assisted research in the life sciences, this interdisciplinary handbook covers terminology, software, and applications of computational biology with academic-level precision. It provides clearly written yet authoritative descriptions of methods and practical examples of their use supported by 975 scholarly works cited. Highlights include methods for pragmatic analysis of nucleic acid and protein sequences and structures, definition and detection of motifs in nucleic acid and protein sequences, protein structure prediction, and discrete modeling of biopolymers.