Manel Esteller – författare

DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its most basic form, means heredity is not the sole determining factor in disease development. Rather, environmental and dietary factors can trigger a gene to behave in an unintended way, while the gene itself remains unchanged. Epigenetics in Biology and Medicinediscusses cell biology and epigenetics’ role in human, animal, and plant diseases, including distortions in DNA methylation. The text also covers histone modifications, and epigenomics, as well as dietary and environmental impacts on epigenetic changes. Addresses These Important Questions: How promising are HDACi drugs as anti-tumor agents?Will restoring normal levels of miRNAs change the course of devastating diseases?Is it possible to alter epigenetic mechanisms once they are triggered?Is it possible to correct the abnormalities in methylation patterns that impact auto-immunities?Represents a Landmark Publication in this Cutting-Edge Field Dr. Manel Esteller, the editor of the volume, is a leading expert in molecular genetics of endometrial carcinoma. Under his editorial guidance, this publication goes beyond heredity to explain the crucial role of epigenetics in plants and physical and psychological diseases. This text is applicable to a wide range of researchers, including those invested in the applications of cell biology, those involved in disease research and deciding genetic patterns, and those coalitions concerned with the impact of epigenetics and possible cures. As a result, it has the potenti

DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book provides a balance between articles clarifying methodological details and more general review chapters that offer broad biological perspectives on DNA methylation. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing.

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its most basic form, means heredity is not the sole determining factor in disease development. Rather, environmental and dietary factors can trigger a gene to behave in an unintended way, while the gene itself remains unchanged. Epigenetics in Biology and Medicinediscusses cell biology and epigenetics’ role in human, animal, and plant diseases, including distortions in DNA methylation. The text also covers histone modifications, and epigenomics, as well as dietary and environmental impacts on epigenetic changes. Addresses These Important Questions: How promising are HDACi drugs as anti-tumor agents?Will restoring normal levels of miRNAs change the course of devastating diseases?Is it possible to alter epigenetic mechanisms once they are triggered?Is it possible to correct the abnormalities in methylation patterns that impact auto-immunities?Represents a Landmark Publication in this Cutting-Edge Field Dr. Manel Esteller, the editor of the volume, is a leading expert in molecular genetics of endometrial carcinoma. Under his editorial guidance, this publication goes beyond heredity to explain the crucial role of epigenetics in plants and physical and psychological diseases. This text is applicable to a wide range of researchers, including those invested in the applications of cell biology, those involved in disease research and deciding genetic patterns, and those coalitions concerned with the impact of epigenetics and possible cures. As a result, it has the potenti

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation

Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors "conspire" to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them.In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is now the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio.

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

¿Puedo heredar las enfermedades de mis padres o abuelos? ¿Es posible que mis hijos hereden las mías? ¿Hasta qué punto una disciplina como la epigenética puede tener repercusión en la prevención y tratamiento de enfermedades como el cáncer, el Parkinson o el Alzheimer? Y, sobre todo, ¿qué es la epigenética?Manel Esteller, todo un referente internacional en el ámbito de la epigenética, responde a estas preguntas y a muchas otras de manera ilustrativa y divulgativa. A partir de doce ejemplos basados en casos reales, expone las claves para entender mejor las bases de esta disciplina y ofrece un panorama de las infinitas posibilidades que genera el estudio de la epigenética. De este modo, los conceptos teóricos encuentran su aplicación práctica en los consejos para llevar una vida saludable que nos permita, prevenir el desarrollo de alguna de estas enfermedades.

El autor de No soy mi ADN desenmascara las fábulas y falsos mitos sobre la enfermedad más común de nuestro tiempo: el cáncer. Autoridad mundial en la materia, Manel Esteller, nos explica que el mejor método para afrontar el cáncer es conociéndolo y desenmascara todos los mitos que hay entorno a él a la vez que revela, con una prosa sencilla y clara, todas las dudas sobre esta enfermedad.¿El cáncer es contagioso? ¿Mi estilo de vida o el lugar dónde trabajo pueden influir para que pueda llegar a tener cáncer? Manel Esteller responde a estas y muchas otras preguntas en este libro clave para conocer y entender los mecanismos de esta enfermedad.

Bien sea para luchar contra enfermedades devastadoras, para poner los pies en Marte o para descubrir un nuevo método para producir energía limpia, jamás como ahora han hecho falta tantos científicos en el mundo. El prestigioso Dr. Manel Esteller, uno de los expertos en biomedicina más reconocidos, acompaña a los jóvenes investigadores con estas emotivas cartas repletas de consejos, anécdotas personales y curiosidades de la historia de la ciencia. Como voz de la experiencia, ofrece con honestidad y generosidad todos los ingredientes necesarios para triunfar en su carrera: pasión, curiosidad, vocación, compañerismo, determinación, tolerancia, imaginación, persistencia...TODAS LAS RESPUESTAS PARA UNA NUEVA GENERACIÓN DE INVESTIGADORES.