Manfred Dietel – författare
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9 produkter
9 produkter
Del 199 - Recent Results in Cancer Research
Pre-Analytics of Pathological Specimens in Oncology
Inbunden, Engelska, 2015
565 kr
Skickas inom 10-15 vardagar
This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.
E-bok
PDF, Engelska, 2015714 kr
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This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.
Häftad, Engelska, 2016
565 kr
Skickas inom 10-15 vardagar
This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.
Del 176 - Recent Results in Cancer Research
Targeted Therapies in Cancer
Inbunden, Engelska, 2007
1 680 kr
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From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients.This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing.Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
E-bok
PDF, Engelska, 20071 565 kr
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From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients.
This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing.
Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy.
This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
Inbunden, Tyska, 2012
3 134 kr
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Der vorliegende Band „Mamma, Weibliches Genitale, Schwangerschaft und Kindererkrankungen“ enthält eine systematische Darstellung der pathologischen Veränderungen der genannten Organe, Organsysteme und Erkrankungsgruppen. Dabei werden alle Erkrankungen, die sich in den verschiedenen, zum Teil miteinander funktionell verbundenen, zum Teil unabhängig voneinander existierenden Organen beobachten lassen, beschrieben. Die Verfasser der verschiedenen Unterkapitel sind renommierte europäische Pathologen aus den verschiedenen Arbeitskreisen, die sich mit den o. g. Themen diagnostisch und wissenschaftlich intensiv beschäftigen. Dabei wird insbesondere auf die modernen Entwicklungen der verschiedenen Teilbereiche eingegangen und die neuen Veränderungen in Terminologie, Klassifikation und molekularen Analysen detailliert dargestellt. Dieses stets unter dem Blickwinkel der diagnostischen Pathologie. Insgesamt ist das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit auf hohem Niveau zu sein.
E-bok
PDF, Tyska, 20122 634 kr
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Der vorliegende Band „Mamma, Weibliches Genitale, Schwangerschaft und Kindererkrankungen“ enthält eine systematische Darstellung der pathologischen Veränderungen der genannten Organe, Organsysteme und Erkrankungsgruppen. Dabei werden alle Erkrankungen, die sich in den verschiedenen, zum Teil miteinander funktionell verbundenen, zum Teil unabhängig voneinander existierenden Organen beobachten lassen, beschrieben. Die Verfasser der verschiedenen Unterkapitel sind renommierte europäische Pathologen aus den verschiedenen Arbeitskreisen, die sich mit den o. g. Themen diagnostisch und wissenschaftlich intensiv beschäftigen. Dabei wird insbesondere auf die modernen Entwicklungen der verschiedenen Teilbereiche eingegangen und die neuen Veränderungen in Terminologie, Klassifikation und molekularen Analysen detailliert dargestellt. Dieses stets unter dem Blickwinkel der diagnostischen Pathologie. Insgesamt ist das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit auf hohem Niveau zu sein.
Del 176 - Recent Results in Cancer Research
Targeted Therapies in Cancer
Häftad, Engelska, 2014
1 234 kr
Skickas inom 10-15 vardagar
From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients.This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing.Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
E-bok
Tyska, 2022241 kr
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Kurz nach der deutschen Wiedervereinigung übernahm Manfred Dietel die Leitung des berühmten Rudolf-Virchow-Hauses. Zweiundzwanzig Jahre lang führte er das Institut für Pathologie der Charité, diente als Dekan und Ärztlicher Direktor und hatte entscheidenden Anteil am Auf- und Umbau des traditionsreichen Berliner Krankenhauses. Nach einer kurzen Darstellung seines Werdegangs schildert Manfred Dietel die turbulenten Ereignisse und kontroversen wissenschaftspolitischen Auseinandersetzungen, die sich nach der Wende in der Berliner Universitätsmedizin abspielten. Spannend und eindrücklich beleuchtet er die oft unglückliche Rolle des Berliner Senats wie auch hausinterne Ost-West-Konflikte und die schwierige Position des Wissenschaftsrates in dieser bewegten Zeit.Anschließend bietet der Autor eine ebenso verständliche wie anschauliche Einführung in das faszinierende Fach der "klinischen und molekularen Pathologie". Die Integration neuer immunologischer und molekularer Techniken hat diesem für die klinische Diagnostik so zentralen Fach in den letzten drei Jahrzehnten – speziell in der Krebsdiagnostik – einen enormen Bedeutungszuwachs beschert. So entwickelte sich etwa die histologische Gewebediagnostik von einer zumeist deskriptiven zur eher prädiktiven, sprich die Therapieentscheidung direkt beeinflussenden, Disziplin. Der Beitrag, den die Pathologie der Charité durch jahrelange intensive Forschungsarbeit in der Onkologie dazu geleistet hat, ist kaum zu überschätzen und wird exemplarisch dargestellt. Abgerundet werden die Innenansichten durch die amüsante Skizzierung besonderer Ereignisse und origineller Aktivitäten sowie persönlicher Erfahrungen.Originell und humorvoll berichtet Manfred Dietel in diesem Buch von den komplexen Abläufen in der weltberühmten Charité und präsentiert so bewegende Einblicke in eine prägende Zeit der Medizingeschichte.