Manfred Zierhut – författare

In recent years the importance of antigen-presenting cells and their influence on the eyes has been elucidated. We have learned that nearly every structure of the eye harbors these cells, yet they differ in their activities and thus in the ways in which they protect against - or participate in - diseases of the eye. Antigen-Presenting Cells and the Eye summarizes current knowledge about ACPs in general, and their role in the eye, in particular.

Free radicals are molecules with an unpaired electron in the outer shell or an electron that was damaged from either attack or from a poor splitting bond. After a free radical is formed it will continue to attack other molecules, which usually results in the damage of tissue or destruction of a healthy cell. Free radicals arise normally through metabolism. However, sometimes the body's immune system will create them on purpose to neutralize viruses and bacteria. Free radicals are implicated in many ophthalmic disorders including uveitis, optic nerve damage, retinal ischemia, and macular degeneration. Free Radicals in Ophthalmic Disorders presents the most current knowledge pertaining to the role of free radicals/oxidants in ocular disorders, and the use of antioxidants in the prevention of these disorders.Written by today's leading ocular scientists and clinicians, Free Radicals in Ophthalmic Disorders: gives comprehensive coverage of the role of free radicals/oxidants in ocular disorders covers the use of antioxidants to prevent oxidative stress and ocular tissue damage examines external factors that may result in the stimulation and heightened occurrence of free radicals/oxidants

In recent years the importance of antigen-presenting cells and their influence on the eyes has been elucidated. We have learned that nearly every structure of the eye harbors these cells, yet they differ in their activities and thus in the ways in which they protect against - or participate in - diseases of the eye. Antigen-Presenting Cells and the

Beh''s Disease (BD) is one of the most-studied systemic disorders characterized by an occlusive vasculopathy of multiple organs. The etiology and pathogenesis of BD are still unclear, but there is evidence for genetic, immunologic and infectious factors in the onset and throughout the course of the disease. This book summarizes our knowledge regarding the most important factors that induce or trigger BD. After an epidemiological overview, the clinical presentation of ocular and non-ocular symptoms of BD is summarized. The immunopathological changes reflect a chronic vasculitis of arterioles, venules, and capillaries. The book covers the role of T-cells, NK-T-cells, secreted cytokines, and neutrophils as well as immune reactions against various microbial heat shock proteins. It shows that the pathogenic gene involved in the development of BD is pinpointed to HLA-B51. It also discusses the treatment of BD, including anti-TNF-alpha-antibodies and interferon-alpha.

In recent years the importance of antigen-presenting cells and their influence on the eyes has been elucidated. We have learned that nearly every structure of the eye harbors these cells, yet they differ in their activities and thus in the ways in which they protect against - or participate in - diseases of the eye. Antigen-Presenting Cells and the

Free radicals are molecules with an unpaired electron in the outer shell or an electron that was damaged from either attack or from a poor splitting bond. After a free radical is formed it will continue to attack other molecules, which usually results in the damage of tissue or destruction of a healthy cell. Free radicals arise normally through met

This well-structured and lavishly illustrated book is a comprehensive reference on intraocular inflammation that encompasses all anatomic forms, settings and etiologies. Individual sections are devoted to uveitis associated with systemic disorders, uveitis syndromes restricted to the eye, bacterial uveitis, viral uveitis, fungal uveitis, parasitic uveitis, uveitis caused by other microbes, traumatic uveitis, and masquerade syndromes. Chapters on the different forms of uveitis are in a homogeneous reader-friendly format, with identification of core messages, explanation of etiology and pathogenesis, up-to-date information on diagnostics and differential diagnosis and guidance on the most appropriate forms of treatment and prognosis. Helpful flow charts are included to assist in identification of potential underlying disorders and the reader will also have online access to one hundred informative case reports demonstrating the different courses of intraocular inflammation. The authorsare world experts keen to share their vast experience with the reader. Intraocular Inflammation will be a valuable resource for all physicians who deal with patients with inflammatory eye disease.

Behçet's Disease (BD) is one of the most-studied systemic disorders characterized by an occlusive vasculopathy of multiple organs. The etiology and pathogenesis of BD are still unclear, but there is evidence for genetic, immunologic and infectious factors in the onset and throughout the course of the disease. Immunology of Behçet's Disease highlights various aspects of BD. After an epidemiological overview, the clinical presentation of ocular and non-ocular symptoms of BD are summarized. The immunopathological changes reflect a chronic vasculitis of arterioles, venules and capillaries. The role of T-cells, but also of NK-T-cells, secreted cytokines and neutrophils is covered. For years microorganisms have been under investigation as initiating BD and, in particular, immune reactions against various microbial heat shock proteins could be an important etiological factor. It has been shown that the pathogenic gene involved in the development of BD is pinpointed to HLA-B51. Finally, the treatment of BD is discussed in detail, including new options like anti-TNF-alpha-antibodies and interferon-alpha. Immunology of Behçet's Disease summarizes our knowledge regarding the most important factors that induce or trigger BD and will stimulate research in the field and help to initiate new ideas.

Free radicals are molecules with an unpaired electron in the outer shell or an electron that was damaged from either attack or from a poor splitting bond. After a free radical is formed it will continue to attack other molecules, which usually results in the damage of tissue or destruction of a healthy cell. Free radicals arise normally through metabolism. However, sometimes the body’s immune system will create them on purpose to neutralize viruses and bacteria. Free radicals are implicated in many ophthalmic disorders including uveitis, optic nerve damage, retinal ischemia, and macular degeneration. Free Radicals in Ophthalmic Disorders presents the most current knowledge pertaining to the role of free radicals/oxidants in ocular disorders, and the use of antioxidants in the prevention of these disorders.Written by today’s leading ocular scientists and clinicians, Free Radicals in Ophthalmic Disorders: gives comprehensive coverage of the role of free radicals/oxidants in ocular disorderscovers the use of antioxidants to prevent oxidative stress and ocular tissue damageexamines external factors that may result in the stimulation and heightened occurrence of free radicals/oxidants

Ocular allergy is the most frequently diagnosed immune disorder of the eye. This book examines the immunologic reactions of ocular allergy in comparison to allergic skin diseases, reviews recent advances in the pathophysiology of ocular allergy and summarizes current clinical knowledge and treatment strategies. It explains the epidemiology of ocular allergy, the role of the environment in allergy, and the clinical manifestation of dermal and ocular allergic disorders. In-depth coverage of vernal and atopic keratoconjunctivitis, seasonal conjunctivitis, urticaria, idiopathic thrombocytopenic purpura, hypersensitivity vasculitis, contact dermatitis and atopic dermatitis is also included.