Marek Prochazka – författare
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This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.
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This book describes recent progress in the mechanistic studies and applications of surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS). In this book, various novel techniques in SERS and TERS such as UV resonance TERS, electrochemical TERS, and three-dimensional SERS imaging are outlined. A number of new applications of SERS and TERS such as those to photonics, nanotechnology, microfluidics, and medical diagnosis along with future perspectives are also discussed. Finally, the applications of new data analysis, models, and machine learning in SERS and TERS studies are reviewed. The novelty of this book is the forming of a new bridge between the theory and applications. Also, the importance of chemical mechanism and that of semiconductor-enhanced Raman scattering is emphasized. The main audiences are researchers in academia, research institutes, companies, and graduate students looking for a comprehensive book on the latest studies of SERS and TERS.