Mark A Atkinson – författare

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing ? cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.

Our understanding of the genetics and pathophysiology of animal models for autoimmune diseases such as type 1 diabetes and multiple sclerosis has increased significantly in the past few years. The central themes of this volume are the necessity for novel and improved models, the optimal use of information from animal models to understand pathogenesis of the human disease, and the rational development of novel immunotherapeutics. This volume is intended to foster discussion on the utility of currently available animal models, to suggest methods for improving upon present models, and to advance translational research in these fields.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member