Mark W. Bondi - Böcker

Since the publication of the first edition of Neuropsychology of Alzheimer's Disease and Other Dementias more than 30 years ago, neuroscientists have made significant improvements in our understanding of the neurobiology, differential diagnoses, and interventions for individuals with Alzheimer's disease and other dementias. Clinical interests also continue due to the worldwide increase in the aging population and the associated trauma experienced by families caring for individuals with dementing illnesses, and with healthcare professionals collaborating in their care.The initial chapters in this thoroughly updated and expanded second edition present the neurobiological bases of dementia and the role of anterograde memory impairment and other important aspects of mild cognitive impairment. These concepts are presented with the key neuropsychological functions and specific cognitive tests as related to differential diagnosis. Normal aging and clinical decision-making are also addressed. Following chapters differentiate Alzheimer's disease from other cognitive disorders, including neurodegenerative conditions, review neuropsychiatric manifestations and comorbidities with particular focus on depression and severe mental illness, and discuss risk and protective factors for dementia as well as potential treatments and prevention methods. The book concludes with recent pharmacological treatments, innovations in behavioral management, and ethical and legal considerations.This authoritative volume will be an indispensable guide and sourcebook for clinicians who face the considerable challenge of improving the quality of life of those affected with these devastating disorders.

In 2011, National Institute on Aging and Alzheimer's Association joint task forces released proposed criteria for Alzheimer' disease diagnosis. These proposals included revisions to the nearly 30-year-old NINDS-ADRDA criteria for Alzheimer's diagnosis and added criteria for diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer's disease. The same year the American Psychiatric Association proposed new criteria for major and minor neurocognitive disorders (the entities previously known as dementia and mild cognitive impairment, respectively). These new criteria reflect the research and clinical advances in identifying mild cognitive impairment and offer new opportunities for prevention, treatment, and management of neurodegenerative conditions. A major focus of this book is on the mild cognitive impairment prodrome of the common dementias. In addition to discussing the most common neurodegenerative conditions, many rare neurodegenerative conditions are highlighted. Most chapters include an autopsy-confirmed case presentation from the authors' files. Following the case presentation, those chapters present current diagnostic criteria, epidemiology, neuropathology/neurophysiology, genetics, neuroimaging studies as relevant, associated clinical features, differential neuropsychological features and possible interventions for each disorder. The pace of change in research and practice in the field of normal cognitive aging and dementia is increasing almost as fast as the median age of the population. The massive baby boom population bubble is currently entering the age of risk for neurodegenerative conditions. Neuropsychologists will play a major role in refining and applying these diagnoses, and in developing, testing, and refining interventions for these diagnoses, and in caring for this population. This book is intended to prepare neuropsychologists and others interested in neuropsychology to serve this fastest growing segment of our population.

This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models.  Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging.  Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.