Markus Löffler – författare

This book constitutes the strictly refereed post-workshop proceedings of the German Conference on Bioinformatics, GCB'96, held in Leipzig, Germany, in September/October 1996. The volume presents 18 revised full papers together with three invited papers; these contributions were selected after a second round of reviewing from the 91 conference presentations. The book addresses current issues in computational biology and biologically inspired computing. The papers are organized in sections on biological and metabolic pathways, sequence analysis, molecular modeling, visualization, and formal languages, and DNA.

Dieses Buch gibt eine Einführung in die Grundlagen und Methoden der heutigen Medizin. Es beginnt mit praktischen Hinweisen aus der großen Erfahrung der Verfasser, führt über die Epidemiologie und Modelltheorien zur Diskussion der allgemeinen Gesundheits- und Krankheitsbegriffe. Es leitet weiter über die Hermeneutik und Anthropologie (mit Genetik und Umweltfaktoren) zu den intuitiven, logischen und mathematischen Grundlagen, gefolgt von den heute gebräuchlichen Methoden der Diagnostik. Es gipfelt schließlich in einer Entscheidungstheorie für die Medizin und in einer allgemeinen Prognostik. Die überall anwendbaren Grundlagen werden anhand zahlreicher Beispiele aus der Praxis plausibel gemacht.

In the field of Hodgkin''s lymphoma, many new data have been collected during the last decade both on the cell of origin of this disease and on more effective therapies to cure the majority of pa­ tients even in the advanced stages. Therefore, it seems to be justi­ fied to compile these new data in a special volume of Recent Re­ sults in Cancer Research. This volume summarizes the contribu­ tions presented at the First International Symposium on Hodgkin''s Disease that took place in Cologne (FRG) on October 2-3, 1988. There is little doubt that the Hodgkin and Reed-Sternberg (H and RS) cells and their variants represent the malignant population in Hodgkin''s lymphoma; however, there is still a fierce debate as to the possible cell of origin of Hand RS cells. Many of the problems confounding earlier research into this question were related to the difficulty or virtual impossibility, of obtaining purified populations of Hand RS cells. Most of the recent progress stems from the establishment of permanent cell lines of Hand RS cells in culture.