Marshall A. Lichtman – författare

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The world''s most highly regarded reference text on the mechanisms and clinical management of blood diseases

A Doody''s Core Title for 2020!

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields.

The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.

Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

A full-color clinical reference covering both common and uncommon blood disorders – referenced to the world’s leading hematology text

Williams Manual of Hematology, Ninth Edition provides a quick-access summary of the epidemiology, etiology, pathogenesis, diagnostic criteria, differential diagnosis, and therapy of blood cell and coagulation protein disorders. The 93 chapters of the Manual are a distillation of the disease- and therapy-focused chapters from the Ninth Edition of Williams Hematology. The book has been carefully edited to deliver only the most clinical point-of-care facts, making differential diagnosis faster, easier, and more efficient.

Concise but comprehensive, this complete guide includes sections on:

• Initial Clinical Evaluation• Disorders of Red Cells• Disorders of Granulocytes• Disorders of Monocytes and Macrophages• Principles of Therapy for Neoplastic Hematological Disorders• The Clonal Myeloid Disorders• The Polyclonal Lymphoid Diseases• The Clonal Lymphoid and Plasma Cell Diseases• Disorders of Platelet and Hemostasis• Disorders of Coagulation Proteins• Thrombosis and Antithrombotic Therapy• Transfusion and Hemapheresis

The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation

Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field.

This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text.

NEW TO THIS EDITION:

Immune Checkpoint Inhibitors

Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy

Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy

The processes of cell death and survival

Application of Big Data and Deep Learning in Hematology

Everything you need to know about red cell disorders, from basic science to clinical application.

When red blood cells do not have enough hemoglobin, oxygen cannot reach all parts of the body—as a result, organs start to malfunction and may lead to a host of issues including deformities, enlarged spleen, heart problems and other diseases. There are myriad red cell disorders, such as iron deficiency anemia, pernicious anemia, aplastic anemia, autoimmune hemolytic anemia, sickle cell, thalassemia and other hemoglobinopathies.

The Red Cells and its Diseases provides clinicians with a practical diagnostic and treatment framework for identifying and successfully managing acute, congenital, and chronic red blood cell disorders. Presented in an accessible template format, the book includes classifications, etiology and pathogenesis, clinical and laboratory features, differential diagnosis, treatment, management, and supportive care.

This comprehensive, yet concise resource covers: