Michael Decker - Böcker

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.

Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.

With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.

Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

This book explores the agrarian landscape and economy of the eastern Mediterranean from modern Israel to Turkey. This region experienced a surge in population between the fifth and sixth centuries AD that raised the population to levels often only regained in the late twentieth century. Cities expanded and the eastern lands reached a pinnacle of cultural expression and economic prosperity in the century before the arrival of Islam. Behind all this lay the ability of Roman farmers to feed themselves by producing a reliable surplus of food. Michael Decker describes precisely how this was done: how plants critical to survival were grown and how new plants were introduced. He also catalogues the range of intensive farming methods used and the rise of cash-crop farming based on olive oil and wine that was traded throughout Europe, western Asia, and parts of Africa.

This book summarises the results of the project TAMI (Technology Assessment in Europe; between Method and Impact). This was a two-year project that brought together the main institutes of technology assessment in Europe, both parliamentary and non-parliamentary. TAMI created a structured dialogue between technology assessment experts and policymakers on current methodologies and their impact on policymaking. The TAMI team explored and assessed the whole spectrum of methodologies from the "classical" to the "interactive/participatory" and "communicative," identified good practices in project implementation and set the stage for impact evaluation based on objective criteria. Finally this report offers a series of policy recommendations based on the findings of the project. Science, Society and Policy, are three areas that technology assessment functions within and works for; this book is an attempt to improve the interaction amongst them for a more socially and economically sustainable Science and Technology policy in Europe.

This book summarises the results of the project TAMI (Technology Assessment in Europe; between Method and Impact). This was a two-year project that brought together the main institutes of technology assessment in Europe, both parliamentary and non-parliamentary. TAMI created a structured dialogue between technology assessment experts and policymakers on current methodologies and their impact on policymaking. The TAMI team explored and assessed the whole spectrum of methodologies from the "classical" to the "interactive/participatory" and "communicative," identified good practices in project implementation and set the stage for impact evaluation based on objective criteria. Finally this report offers a series of policy recommendations based on the findings of the project. Science, Society and Policy, are three areas that technology assessment functions within and works for; this book is an attempt to improve the interaction amongst them for a more socially and economically sustainable Science and Technology policy in Europe.