Michael Decker – författare

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.

Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.

With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.

Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer''s, cancer, and malaria.With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.- Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes- Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied- Compares the advantages and disadvantages of these compounds- Includes the very latest developments, such as photoactivatable and photo-responsive drugs

This book explores the agrarian landscape and economy of the eastern Mediterranean from modern Israel to Turkey. This region experienced a surge in population between the fifth and sixth centuries AD that raised the population to levels often only regained in the late twentieth century. Cities expanded and the eastern lands reached a pinnacle of cultural expression and economic prosperity in the century before the arrival of Islam. Behind all this lay the ability of Roman farmers to feed themselves by producing a reliable surplus of food. Michael Decker describes precisely how this was done: how plants critical to survival were grown and how new plants were introduced. He also catalogues the range of intensive farming methods used and the rise of cash-crop farming based on olive oil and wine that was traded throughout Europe, western Asia, and parts of Africa.

The results of recent archaeological excavation, systematic rural survey and detailed studies of pottery distributions have revealed the extent and complexities of the economy in the eastern empire. The eight papers in this volume demonstrate this complexity and prosperity, examining several types of product and how the economy evolved over time. Contents: New Rome, new theories on Inter-regional exchange: East Mediterranean economy in Late Antiquity ( Sean Kingsley and Michael Decker ); Urban Economies of Late Antique Cyrenaica ( Andrew Wilson ); The economic impact of the Palestinian wine trade in Late Antiquity ( Sean Kingsley ); Food for an empire: wine and oil production in North Syria ( Michael Decker ); Beyond the amphora: non-ceramic evidence for Late Antique industry and trade ( Marlia Mundell Mango ); The economy of Late Antique Cyprus ( Tassos Papacostas ); LR2: a container for the military annona on the Danubian border? ( Olga Karagiorgou ); Specialization, trade and prosperity: an overview of the economy of the Late Antique Eastern Mediterranean ( Bryan Ward-Perkins ).

The Europaische Akademie zur Erforschung von Folgen wissenschaftlich-techni­ scher Entwicklungen Bad Neuenahr-Ahrweiler GmbH (european academy) is con­ cerned with the scientific study of the consequences of scientific and technological advance for the individual and social life and for the natural environment. The main focus is to examine foreseeable mid-and long-term processes that are especially influenced by natural-and engineering sciences and the medical disciplines. The academy fulfills this task by organizing interdisciplinary expert discussions. Another important issue of the work of the Europaische Akademie concerns the methodology of Technology Assessment as a general issue. This is the main reason that the european academy organized during the past two years a project funded by the European Commission on Technology Assessment. Methods and Impact (TAMI). Together with partners from all over Europe a common understanding of what Tech­ nology Assessment (TA) is supposed to do was developed. Most importantly it was acknowledged that the core of any TA activity has to be a sound scientific under­ standing of the relevant phenomena. Communication then is of cordial importance to reach the relevant decision makers as well as the general public. It is true that this phase of the TA process has been treated with too little attention for many years. The communication processes between scientific advisers and policy makers have hence to be further scrutinized.

The Europaische Akademie zur Erforschung von Folgen wissenschaftlich-techni­ scher Entwicklungen Bad Neuenahr-Ahrweiler GmbH (european academy) is con­ cerned with the scientific study of the consequences of scientific and technological advance for the individual and social life and for the natural environment. The main focus is to examine foreseeable mid-and long-term processes that are especially influenced by natural-and engineering sciences and the medical disciplines. The academy fulfills this task by organizing interdisciplinary expert discussions. Another important issue of the work of the Europaische Akademie concerns the methodology of Technology Assessment as a general issue. This is the main reason that the european academy organized during the past two years a project funded by the European Commission on Technology Assessment. Methods and Impact (TAMI). Together with partners from all over Europe a common understanding of what Tech­ nology Assessment (TA) is supposed to do was developed. Most importantly it was acknowledged that the core of any TA activity has to be a sound scientific under­ standing of the relevant phenomena. Communication then is of cordial importance to reach the relevant decision makers as well as the general public. It is true that this phase of the TA process has been treated with too little attention for many years. The communication processes between scientific advisers and policy makers have hence to be further scrutinized.

Bachelor Thesis from the year 2012 in the subject Business economics - Supply, Production, Logistics, grade: 2,3, University of Cologne (Department of Supply Chain Management and Management Science), course: Supply Chain Management, language: English, abstract: Due to the latest catastrophes caused by both man and nature, humanitarian logistics has received increasing interest from academics, practitioners and specialists. These interests are increased as well by an expanding market of disaster relief and by the fact that disaster relief supply chains are complex and dynamic, not to mention that they have a lot of uncertainties that make operations very complicated. Especially in disaster relief, the supply chains have to be fast, agile and flexible in order to rapidly provide the appropriate amount, and type of emergency supplies, to minimize human suffering or death. The last mile distribution is the final stage of the disaster relief supply chain, i.e. the delivery of relief supplies from local distribution centres to beneficiaries affected by disasters. The main problems for the last mile are: Supplies have to be carried out rapidly in an environment with destabilized infrastructures Limitations related to transportation resources and emergency supplies Lack of coordination among relief actors Insufficient information about demand and need for help To solve these problems, the private sector approaches of the last mile can be conducted and innovative technologies can be implemented. The aim of this paper is to give an overview of supply chains in disaster relief, identify the main problems of the last mile distribution in disaster relief operations, describe optimization possibilities of the private sector, and examine the applicability for disaster situations.

The Europaische Akademie zur Erforschung von Folgen wissenschaftlich-techni­ scher Entwicklungen Bad Neuenahr-Ahrweiler GmbH (european academy) is con­ cerned with the scientific study of the consequences of scientific and technological advance for the individual and social life and for the natural environment. The main focus is to examine foreseeable mid-and long-term processes that are especially influenced by natural-and engineering sciences and the medical disciplines. The academy fulfills this task by organizing interdisciplinary expert discussions. Another important issue of the work of the Europaische Akademie concerns the methodology of Technology Assessment as a general issue. This is the main reason that the european academy organized during the past two years a project funded by the European Commission on Technology Assessment. Methods and Impact (TAMI). Together with partners from all over Europe a common understanding of what Tech­ nology Assessment (TA) is supposed to do was developed. Most importantly it was acknowledged that the core of any TA activity has to be a sound scientific under­ standing of the relevant phenomena. Communication then is of cordial importance to reach the relevant decision makers as well as the general public. It is true that this phase of the TA process has been treated with too little attention for many years. The communication processes between scientific advisers and policy makers have hence to be further scrutinized.

Der intensiv diskutierte Begriff Transformation bezeichnet den umfassenden Umbau gesellschaftlicher Strukturen, um gesellschaftliche Herausforderungen durch tiefgreifende Veränderungen der Energie-, Verkehrs-, Produktions- und Agrarsysteme zu adressieren. Da solch komplexe Transformationen stets mit Unsicherheiten über Effekte und Folgen einhergehen, setzen sich die Beiträge kritisch mit den Chancen und Risiken dieser Prozesse auseinander und diskutieren Möglichkeiten und Grenzen der Technikfolgenabschätzung im Kontext gesellschaftlicher Transformationsprozesse. Der Band versammelt die wissenschaftlichen Beiträge der 8. internationalen Konferenz des Netzwerks Technikfolgenabschätzung, die vom 7. bis 8. November 2018 in Karlsruhe stattfand.Mit Beiträgen vonFabian Adelt, Marius Albiez, Annika Arnold, Walaa Bashary, Anja Bauer, Richard Beecroft, Alexander Bogner, Stefan Böschen, Tanja Bratan, Simone Colombo, Michael Decker, Rico Defila, Antonietta Di Giulio, Marion Dreyer, Elisabeth Ehrensperger, Philipp Ellett, Lorenz Erdmann, Ali Abdelshafy Ezzat, Erik Fisher, Michael Friedewald, Livia Fritz, Daniela Fuchs, Maryegli Fuss, Armin Grunwald, Niklas Gudowsky, Kristin Hagen, Simeon Hassemer, Alexandra Hausstein, Nils B. Heyen, Diego Iván Hidalgo Rodriguez, Peter Hocke, Florian Hoffmann, Sebastian Hoffmann, Michael Jonas, Dorothee Keppler, Jeanette Klink-Lehmann, Hannah Kosow, Cordula Kropp, Sophie Kuppler, Bastian Lange, Wolfgang Liebert, Ralf Lindner, Stephan Lingner, Andreas Lösch, Maria Maia, Martin Nicholas, Melanie Mbah, Franziska Meinherz, Rolf Meyer, Johanna Myrzik, Lisa Nabitz, Linda Nierling, Oliver Parodi, Witold-Roger Poganietz, Carmen Priefer, Filippo Reale, Ernst Dieter Rossmann, André Schaffrin, Dirk Scheer, Constanze Scherz, Jan Cornelius Schmidt, Maike Schmidt, Flurina Schneider, Andreas Seebacher, Astrid Segert, Mahshid Sotoudeh, Helge Torgersen, Ulrich Ufer, Karsten Weber, Matthias Weber und Johannes Weyer.