Michael J. Parnham – författare

Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries.

Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. H�kfelt and V.C. Jordan.

Contains primary-source documents currently unavailable elsewhere Presents the science behind major pharmacological breakthroughs by those who discovered them Includes commentary contextualizing the importance of discoveries and related readings

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

Contains primary-source documents currently unavailable Presents the science behind major pharmacological breakthroughs by those who discovered them Includes commentary that contextualizes the importance of discoveries and related readings

Haemodynamics and Immune Defence: Discoveries in Pharmacology, Second Edition, Volume Three presents selected articles from the historic Discoveries in Pharmacology series that are enhanced with commentary from contemporary scholars who discuss the reception and importance of each chapter along with an updated bibliography on the subject and contributions from those involved in Nobel Prize winning discoveries and pioneering advancements in Pharmacology. This volume brings forth discussions on key discoveries in hemodynamics and immune defense, including chapters on penicillin by Dr. Selwyn and asthma by Dr. Brocklehurst.

Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area, will find this useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

Contains important primary-source documents currently unavailable Presents the science behind major pharmacological breakthroughs by those who discovered them Includes commentary that contextualizes the importance of discoveries and related readings

Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks.The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third sectioncontains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests.Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions.The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

Many effective analgesic drugs are available for the relief of acute pain, but their clinical use is widely regarded as being inadequate. The reasons cited for this include concern about the adverse effects of opioids and also insufficient adjustment of therapy to the patient's needs. Non-opioid anal- gesics are the staple drugs for mild to moderate pain and are generally better tolerated than opioid drugs. Differences exist, however, among the non-opioid analgesics which affect the choice of drug for individual pa- tients and specific acutely painful conditions. In an associated symposium of the 7th International Symposium: The Pain Clinic, held in Istanbul, Turkey, the ways were discussed in which treatment with non-opioid analgesics can be tailored to meet the needs of individual patients with acute pain. The highlights of this Hoechst sympo- sium, emphasize the distinctions between the non-steroidal anti-inflamma- tory drugs, and the non-acidic antipyretic analgesics, particularly dipyrone. 9 Mechanisms of action of non-opioid analgesics Professor F. C. Tulunay, M.D.Ankara, Turkey The non-opioid analgesics are among the oldest class of synthetic drugs still in widespread clinical use. They can be divided into the non-steroidal anti-inflammatory drugs (NSAIDs), such as acetylsalicylic acid, and the non-acidic, antipyretic analgesics, paracetamol and dipyrone. The pharma- cology of these various agents will be reviewed briefly.

Dipyrone is an antipyretic analgesic with an additional intrinsic spasmolytic activity. It has been in clinical use for the last 75 years, but about 20 years ago, concern arose over the implications of isolated reports of agranulocytosis following the use of dipyrone, the Swedish authorities ordered the withdrawal of the drug from the market. Subsequently, dipyrone has been subjected to comparative epidemiological and clinical studies, and these showed that dipyrone was a versatile analgesic with an overall risk of serious adverse effects than most other non-opioid analgesics. The Swedish authorities therefore approved the reintroduction of dipyrone as a contribution to pain treatment. This text contains the highlights of a symposium on the action, efficacy, and safety of dipyrone, and highlight the therapeutic basis for the use of dipyrone in the treatment of acute post-operative pain.