Michael K. Johnson – författare

Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins

Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved.

An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research.

Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins

Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved.

An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research.

Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Hoo-Doo Cowboys and Bronze Buckaroos undertakes an interdisciplinary exploration of the African American West through close readings of texts from a variety of media. This approach allows for both an in-depth analysis of individual texts and a discussion of material often left out or underrepresented in studies focused only on traditional literary material. The book engages heretofore unexamined writing by Rose Gordon, who wrote for local Montana newspapers rather than for a national audience; memoirs and letters of musicians, performers, and singers (such as W. C. Handy and Taylor Gordon), who lived in or wrote about touring the American West; the novels and films of Oscar Micheaux; black-cast westerns starring Herb Jeffries; largely unappreciated and unexamined episodes from the "golden age of western television" that feature African American actors; film and television westerns that use science fiction settings to imagine a "postracial" or "postsoul" frontier; Percival Everett''s fiction addressing contemporary black western experience; and movies as recent as Quentin Tarantino''s Django Unchained.

Despite recent interest in the history of the African American West, we know very little about how the African American past in the West has been depicted in a full range of imaginative forms. Hoo-Doo Cowboys and Bronze Buckaroos advances our discovery of how the African American West has been experienced, imagined, portrayed, and performed.