Michael Locke – författare

Insect Biology in the Future: ""VBW 80"" contains essays presented to Sir Vincent Wigglesworth during his 80th year. Wigglesworth is fairly designated as the founding father and remarkable leader of insect physiology. His papers and other works significantly contribute to this field of study. This book, dedicated to him, underlines the value of insect material in approaching a wide spectrum of biological issues. The essays in this book tackle the insects'' physiology, including their evolution and dominance. The papers also discuss the various avenues of water loss and gain as interrelated components of overall water balance in land arthropods. This reference suggests possible areas for further research mainly at the whole animal level. It also describes the fat body, hemolymph, endocrine control of vitellogenin synthesis, reproduction, growth, hormones, chemistry, defense, and survival of insects. Other topics of importance include cell communication and pattern formation in insects; plant-insect interaction; and insecticides.

Major Problems in Developmental Biology contains the proceedings of the 25th Symposium of the Society for Developmental Biology, held in Haverford, Pennsylvania, in June 1966. The papers explore some of the major problems in developmental biology, particularly those relating to cell differentiation, movements, and death; patterning; and intercellular regulation in plants. Organized into 11 chapters, this book begins with an overview of the growth and development of developmental biology as a scientific discipline, with emphasis on the role of the Society for Developmental Biology, and in particular its symposia, in the emergence of the field. The book then discusses the intra- and extracellular factors impinging upon the nucleus and regulating cell differentiation. Some chapters focus on the dynamics of determination in cell systems of insects, morphogenetic movements of animal cells, and patterns at the cell and tissue levels. The reader is also introduced to the correlations between protein structure and function in relation to cell dynamics and differentiation, along with the physiological, biochemical, and molecular biological aspects of intercellular regulation in plants and the role of cell surface in carcinogenesis. The book concludes by suggesting directions for research into the ontogeny of behavior. This book is a valuable source of information for developmental biologists.

Cellular Membranes in Development covers the proceedings of the 1963 22nd Symposium on ""The Society for the Study of Development and Growth"" held in Storrs, Connecticut. This book is organized into 10 chapters that discuss the properties, isolation, function, composition, and physiological aspects of membranes. After briefly dealing with the principles of the unit membrane concept, the book describes the properties of lipid membranes of bilayer thickness with biological relevance. The next chapter focuses on hepatic cell and the modifications of the endoplasmic reticulum in cell differentiation in normal and cancerous growth. Another chapter describes the developmental changes in a particular experimental systems and the modification of the membranes by specific treatments using the apical portion of the primary root of Zea mays. The book also discusses the role of the different organelles in development, supporting the idea of topological continuity between the membranes of all the organelles except the mitochondria. Other chapters describe the cytology of oogenesis and fertilization in Pteridium aquilinum; the early events of fertilization in Hydroides and Saccoglossus; and the composition of cell walls of bacteria, yeast, and fungi. Some aspects of the capsules, microcapsules, and sheaths exhibited by some microorganisms are also covered. The last chapters deal with the quantitative aspects of plant cell permeation and permeability function and changes in relation to maturation and growth hormones. The book is an ideal source for cell biologists and researchers, evolutionists, and biochemists.

The Emergence of Order in Developing Systems is a collection of papers presented at the 27th Symposium of the Society for Developmental Biology, held in Ithaca, New York in June 1968. Contributors focus on the emergence of orderly patterns during development, touching on topics ranging from the three-dimensional structure of the protein molecule to the polymerization of structural units, the self-assembly of microtubules in axonemes, and the patterning of plant cell walls. This volume is organized into four sections encompassing 11 chapters and begins with an overview of the emergence of order during cellular differentiation and growth, paying particular attention to the spontaneous formation of the three-dimensional structure of proteins. The next chapters explore self-association reactions in solutions of myosin molecules; ordering of subcellular units; factors that order the distribution of microtubules and thus ultimately pattern the shape of the cell; the biochemical organization of cytoplasmic membranes through self-assembly; and patterning in cell walls of higher plants. The book also explains the emergence of order in tissues and organs, and then concludes with a discussion on the emergence of order on the behavioral level. This book will be of interest to developmental biologists and embryologists.

Reproduction: Molecular, Subcellular, and Cellular is a collection of papers presented at the Twenty-Fourth Symposium of The Society for Developmental Biology, held at Carleton, Minnesota in June 1965. The papers in the compendium focus on the clarification and definition of specific aspects of reproduction at different levels of biological organization. Topics discussed include the transcription and translation of genes; interactions between plant viruses and host cells; chromosome reproduction in mitosis and meiosis; cell and tissue interactions in the reproduction of cell type; and aging as a consequence of growth cessation. Biologists, microbiologists, and cytologists will find the book insightful.

Control Mechanisms in Developmental Processes covers the proceedings of the 1967 26th Symposium of The Society for Developmental Biology, held in La Jolla, California. This book is divided into three parts encompassing 10 chapters that summarize the role of cytoplasmic units and the nucleus in developmental processes and the regulatory mechanisms. The opening part of the book describes the chemical changes during the development of plastids in leaves of higher plants. The book goes on discussing the nuclear and cytoplasmic controls in Neurospora morphology. This compilation also examines the aspects of development, growth, and control in the basal bodies and flagella of Chlamydomonas reinhardii. The second part describes genetic systems in plants that serve to initiate or program the sequence in plant development and the life cycle of hybrids between somatic cells of different species. A chapter discusses the genetic basis of higher plant morphogenesis by analysis of the differences between genotypes that differ from each other with respect to a single gene having a pronounced and highly specific effect upon form. A discussion on the activation of protein synthesis upon fertilization and early development of animal eggs to the biochemical basis of the determination process is also included. The concluding part deals with the differentiation of erythroid cells; the induction of hemoglobin synthesis; the regulation of heme and globin synthesis; and the role of heme in the synthesis and assembly of hemoglobin. This part also describes the differentiation of cells to the point where they can perform the various types of immunological reactions. This book is an invaluable source for developmental biologists and researchers.

The Role of Chromosomes in Development is a collection of papers presented at the 23rd Symposium of the Society for the Study of Development and Growth, held at Amherst, Massachusetts in June 1964. Contributors explore the role of chromosomes in development, highlighting important processes such as the diversification and specialization of cells; the regulation of gene function by the physical state of the chromosome; the functional organization of chromosomes; DNA replication and synthesis; and macronuclear differentiation and subnuclear assortment. This volume is organized into 11 chapters and begins with an overview of chromosome structure and function and the mechanisms underlying the role of the chromosome in embryonic development. This book then discusses the chromosomal DNA replication, the mechanisms of gene modulation, the binding of actinomycin to DNA, and the cytological aspects of DNA replication in higher animals. The next chapters explain localized DNA synthesis in polytene chromosomes; chromosomal RNA and other nuclear RNA fractions; and experimental work probing both genetic and functional mosaicism in the mouse, as well as genetic repression of the R locus in maize. The book also considers how developmental pathways are controlled by genetic mechanisms, and then concludes with a chapter on nuclear differentiation in ciliates and on the phenomenon of subnuclear assortment. This book will be of interest to developmental biologists and embryologists.

Cytodifferentiation and Macromolecular Synthesis focuses on research on biosynthesis, structure, and morphology of cells. The book first discusses cytodifferentiation and macromolecular synthesis and genetic control of protein structure. The relationship of amino acid substitutions to the genetic code; comparison of gene and protein alterations; and suppressor mutations are described. The text also looks at genetic repression, allosteric inhibition, and cellular differentiation; epigenetic control of protein synthesis in cells; quantitative studies of protein synthesis in embryonic tissues; and chromosomes and cytodifferentiation. The book also discusses the morphological and chemical differentiation of plastids. The effect of light on plastid development; structure of mature chloroplast; morphological changes in the development of proplastid to the chloroplast; and inheritable factors that control plastids are described. The text also focuses on the collagen system, mechanisms of elongation, and tissue interaction and metabolic responses. The book is a valuable reference for readers wanting to conduct research on the complex nature of cells.

The Role of Chromosomes in Development is a collection of papers that deals with structural patterns and functional organization of chromosomes. Some papers discuss chromosomal proteins, DNA replication sequences in higher animals, and the implications of localized DNA synthesis in polytene chromosomes. Several papers describe chromosomal RNA, nuclear RNA fractions, genetic control, and the regulation of developmental pathways. One paper concerns the "bithorax" series that controls the development of certain body segments of the fly in a polarized and coordinated manner reminiscent of the genes in the operons of microorganisms. The bithorax genes evidently exploit and amplify a gradient arising from an anteroposterior gradient during mitotic division rates. The bithorax genes produces a whole set of new substances that repress certain systems of cellular differentiation, letting other systems to emerge and develop. Another paper investigates the hypothesis of diploid subnuclei as the architectural subunit of the ciliate macronucleus, as well as the hypothesis of "allelic repression" as the basis for certain examples of subnuclear differentiation. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.

Developmental Biology, Supplement 1: Control Mechanisms in Developmental Processes focuses on the process of how organs grow and develop. This book is organized into three main topics—role of cytoplasmic units, role of the nucleus, and regulatory mechanisms. This compilation specifically discusses the control mechanisms in plastid development, nuclear control of morphology, and possible involvement of mitochondrial DNA. The mode of operation of a regulatory system in maize, hooded gene in barley, and regulation of the cell cycle in mammalian cells are also described. This text likewise considers the development of immunocompetent cells, regulatory action of estrogenic hormones, and biological activity of uterine RNA. This publication is suitable for biologists, specialists, and students concerned with developmental processes.

Muscle aims to consider aspects of the structure and function of selected muscle cells, primarily from vertebrates and arthropods, with the use of diagrams, light micrographs, and electron micrographs. The book begins by briefly tracing the historical development of studies on muscles. Pioneering studies established that while many cells show the property of contractility to a limited degree, muscle cells, whether striated or unstriated, are most obviously adapted to their function by hypertrophy of the fibrillar material rather than by acquisition of a unique set of cytoplasmic components. Separate chapters cover topics such as the striated muscle; the arrangement of myofibrils in striated muscle; the sarcomere and the molecular events of contraction; cytochemical demonstration of myofibrillar ATPase; and variation in the actin. Subsequent chapters deal with the functions of the mitochondria, nucleus, neuromuscular junction, plasma membrane, transverse tubular system, and sarcoplasmic reticulum. Also discussed are the cardiac muscle, smooth muscle, and muscle insertions.

This report is based on an action research project which involved service users, managers, staff and trustees. It identifies enablers of and barriers to increased user involvement. It also describes emerging approaches and important themes. It will help practitioners, managers and trustees plot their own journeys towards increased user involvement.The report:proposes 'user-centred user involvement', distinguishing it from 'management-centred user involvement', as a tool for analysing whose interests are served;  highlights critical factors that enable change, such as: leadership style, consistent commitment, building strong relationships and communication between decision makers and users; can be used to assess if the conditions for developing user-centred user involvement exist; can also be used for planning change.This report is aimed at managers, service users, trustees and consultants who are working to increase user involvement in their own organisations. It will also be useful to researchers as a contribution to knowledge and debates about user involvement.