Michael Potter - Böcker

How do we account for the truth of arithmetic? And if it does not depend for its truth on the way the world is, what constrains the world to conform to arithmetic? Reason's Nearest Kin is a critical examination of the astonishing progress made towards answering these questions from the late nineteenth to the mid-twentieth century. In the space of fifty years Frege, Dedekind, Russell, Wittgenstein, Ramsey, Hilbert, and Carnap developed accounts of the content of arithmetic that were brilliantly original both technically and philosophically. Michael Potter's innovative study presents them all as finding that content in various aspects of the complex linkage between experience, language, thought, and the world. Potter's reading places them all in Kant's shadow since it was his attempt to ground arithmetic in the spatio-temporal structure of reality that they were reacting against; but it places us in Gödel's shadow since his incompleteness theorems supply us with a measure of the richness of the content they were trying to explain. This stimulating reassessment of some of the classic texts in the philosophy of mathematics reveals many unexpected connections and illuminating comparisons, and offers a wealth of ideas for future work in the subject.

Wittgenstein's philosophical career began in 1911 when he went to Cambridge to work with Russell. He compiled the Notes on Logic two years later as a kind of summary of the work he had done so far. Russell thought that they were 'as good as anything that has ever been done in logic', but he had Wittgenstein himself to explain them to him. Without the benefit of Wittgenstein's explanations, most later scholars have preferred to treat the Notes solely as an interpretative aid in understanding the Tractatus (which draws on them for material), rather than as a philosophical work in their own right.Michael Potter unequivocally demonstrates the philosophical and historical importance of the Notes for the first time. By teasing out the meaning of key passages, he shows how many of the most important insights in the Tractatus they contain. He discusses in detail how Wittgenstein arrived at these insights by thinking through ideas he obtained from Russell and Frege. And he uses a challenging blend of biography and philosophy to illuminate the methods Wittgenstein used in his work. The book features the complete text of the Notes in a critical edition, with a detailed discussion of the circumstances in which they were compiled, leading to a new understanding of how they should be read.

What is the nature of mathematical knowledge? Is it anything like scientific knowledge or is it sui generis? How do we acquire it? Should we believe what mathematicians themselves tell us about it? Are mathematical concepts innate or acquired? Eight new essays offer answers to these and many other questions. Written by some of the world's leading philosophers of mathematics, psychologists, and mathematicians, Mathematical Knowledge gives a lively sense of the current state of debate in this fascinating field.

How do we account for the truth of arithmetic? And if it does not depend for its truth on the way the world is, what constrains the world to conform to arithmetic? Reason's Nearest Kin is a critical examination of the astonishing progress made towards answering these questions from the late nineteenth to the mid-twentieth century. In the space of fifty years Frege, Dedekind, Russell, Wittgenstein, Ramsey, Hilbert, and Carnap developed accounts of the content of arithmetic that were brilliantly original both technically and philosophically. Michael Potter's innovative study presents them all as finding that content in various aspects of the complex linkage between experience, language, thought, and the world. Potter's reading places them all in Kant's shadow, since it was his attempt to ground arithmetic in the spatio-temporal structure of reality that they were reacting against; but it places us in Gödel's shadow since his incompleteness theorems supply us with a measure of the richness of the content they were trying to explain. This stimulating reassessment of some of the classic texts in the philosophy of mathematics reveals many unexpected connections and illuminating comparisons, and offers a wealth of ideas for future work in the subject.

A comprehensive philosophical introduction to set theory. Anyone wishing to work on the logical foundations of mathematics must understand set theory, which lies at its heart. Potter offers a thorough account of cardinal and ordinal arithmetic, and the various axiom candidates. He discusses in detail the project of set-theoretic reduction, which aims to interpret the rest of mathematics in terms of set theory. The key question here is how to deal with the paradoxes that bedevil set theory. Potter offers a strikingly simple version of the most widely accepted response to the paradoxes, which classifies sets by means of a hierarchy of levels. What makes the book unique is that it interweaves a careful presentation of the technical material with a penetrating philosophical critique. Potter does not merely expound the theory dogmatically but at every stage discusses in detail the reasons that can be offered for believing it to be true.

Michael Potter presents a comprehensive new philosophical introduction to set theory. Anyone wishing to work on the logical foundations of mathematics must understand set theory, which lies at its heart.Potter offers a thorough account of cardinal and ordinal arithmetic, and the various axiom candidates. He discusses in detail the project of set-theoretic reduction, which aims to interpret the rest of mathematics in terms of set theory. The key question here is how to deal with the paradoxes that bedevil set theory. Potter offers a strikingly simple version of the most widely accepted response to the paradoxes, which classifies sets by means of a hierarchy of levels.What makes the book unique is that it interweaves a careful presentation of the technical material with a penetrating philosophical critique. Potter does not merely expound the theory dogmatically but at every stage discusses in detail the reasons that can be offered for believing it to be true. Set Theory and its Philosophy is a key text for philosophy, mathematical logic, and computer science.

Wittgenstein's philosophical career began in 1911 when he went to Cambridge to work with Russell. He compiled the Notes on Logic two years later as a kind of summary of the work he had done so far. Russell thought that they were 'as good as anything that has ever been done in logic', but he had Wittgenstein himself to explain them to him. Without the benefit of Wittgenstein's explanations, most later scholars have preferred to treat the Notes solely as an interpretative aid in understanding the Tractatus (which draws on them for material), rather than as a philosophical work in their own right. Michael Potter unequivocally demonstrates the philosophical and historical importance of the Notes for the first time. By teasing out the meaning of key passages, he shows how many of the most important insights in the Tractatus they contain. He discusses in detail how Wittgenstein arrived at these insights by thinking through ideas he obtained from Russell and Frege. And he uses a challenging blend of biography and philosophy to illuminate the methods Wittgenstein used in his work. The book features the complete text of the Notes in a critical edition, with a detailed discussion of the circumstances in which they were compiled, leading to a new understanding of how they should be read.

This volume of newly written chapters on the history and interpretation of Wittgenstein's Tractatus represents a significant step beyond the polemical debate between broad interpretive approaches that has recently characterized the field. Some of the contributors might count their approach as 'new' or 'resolute', while others are more 'traditional', but all are here concerned primarily with understanding in detail the structure of argument that Wittgenstein presents within the Tractatus, rather than with its final self-renunciation, or with the character of the understanding that renunciation might leave behind. The volume makes a strong case that close investigation, both biographical and textual, into the composition of the Tractatus, and into the various influences on it, still has much to yield in revealing the complexity and fertility of Wittgenstein's early thought. Amongst these influences Kant and Kierkegaard are considered alongside Wittgenstein's immediate predecessors in the analytic tradition. The themes explored range across the breadth of Wittgenstein's book, and include his accounts of ethics and aesthetics, as well as issues in metaphysics and the philosophy of mind, and aspects of the logical framework of his account of representation. The contrast of saying and showing, and Wittgenstein's attitude to the inexpressible, is of central importance to many of the contributions. By approaching this concern through the various first-level issues that give rise to it, rather than from entrenched schematic positions, the contributors demonstrate the possibility of a more inclusive, constructive and fruitful mode of engagement with Wittgenstein's text and with each other.

Gottlob Frege (1848-1925) was unquestionably one of the most important philosophers of all time. He trained as a mathematician, and his work in philosophy started as an attempt to provide an explanation of the truths of arithmetic, but in the course of this attempt he not only founded modern logic but also had to address fundamental questions in the philosophy of language and philosophical logic. Frege is generally seen (along with Russell and Wittgenstein) as one of the fathers of the analytic method, which dominated philosophy in English-speaking countries for most of the twentieth century. His work is studied today not just for its historical importance but also because many of his ideas are still seen as relevant to current debates in the philosophies of logic, language, mathematics and the mind. The Cambridge Companion to Frege provides a route into this lively area of research.

Gottlob Frege (1848-1925) was unquestionably one of the most important philosophers of all time. He trained as a mathematician, and his work in philosophy started as an attempt to provide an explanation of the truths of arithmetic, but in the course of this attempt he not only founded modern logic but also had to address fundamental questions in the philosophy of language and philosophical logic. Frege is generally seen (along with Russell and Wittgenstein) as one of the fathers of the analytic method, which dominated philosophy in English-speaking countries for most of the twentieth century. His work is studied today not just for its historical importance but also because many of his ideas are still seen as relevant to current debates in the philosophies of logic, language, mathematics and the mind. The Cambridge Companion to Frege provides a route into this lively area of research.

In this book Michael Potter offers a fresh and compelling portrait of the birth of modern analytic philosophy, viewed through the lens of a detailed study of the work of the four philosophers who contributed most to shaping it: Gottlob Frege, Bertrand Russell, Ludwig Wittgenstein, and Frank Ramsey. It covers the remarkable period of discovery that began with the publication of Frege's Begriffsschrift in 1879 and ended with Ramsey's death in 1930. Potter—one of the most influential scholars of this period in philosophy—presents a deep but accessible account of the break with absolute idealism and neo-Kantianism, and the emergence of approaches that exploited the newly discovered methods in logic. Like his subjects, Potter focusses principally on philosophical logic, philosophy of mathematics, and metaphysics, but he also discusses epistemology, meta-ethics, and the philosophy of language. The book is an essential starting point for any student attempting to understand the work of Frege, Russell, Wittgenstein, and Ramsey, as well as their interactions and their larger intellectual milieux. It will also be of interest to anyone who wants to cast light on current philosophical problems through a better understanding of their origins.

In this book Michael Potter offers a fresh and compelling portrait of the birth of modern analytic philosophy, viewed through the lens of a detailed study of the work of the four philosophers who contributed most to shaping it: Gottlob Frege, Bertrand Russell, Ludwig Wittgenstein, and Frank Ramsey. It covers the remarkable period of discovery that began with the publication of Frege's Begriffsschrift in 1879 and ended with Ramsey's death in 1930. Potter—one of the most influential scholars of this period in philosophy—presents a deep but accessible account of the break with absolute idealism and neo-Kantianism, and the emergence of approaches that exploited the newly discovered methods in logic. Like his subjects, Potter focusses principally on philosophical logic, philosophy of mathematics, and metaphysics, but he also discusses epistemology, meta-ethics, and the philosophy of language. The book is an essential starting point for any student attempting to understand the work of Frege, Russell, Wittgenstein, and Ramsey, as well as their interactions and their larger intellectual milieux. It will also be of interest to anyone who wants to cast light on current philosophical problems through a better understanding of their origins.

“An excellent analysis of the complex dynamics of inclusion in post-conflict societies: theoretically grounded, empirically rich, and with a well-informed set of policy-relevant insights and recommendations with implications far beyond the cases of Kosovo and Northern Ireland.”Stefan Wolff, University of Birmingham, UK“Does the promotion of political accommodation between the contending parties in an ethno-nationalist conflict disadvantage other groups in society? This important question is at the heart of Michael Potter's nuanced study of post-settlement parliaments in Kosovo and Northern Ireland, in which he probes their record of representativeness, focusing on gender and ethnicity. His meticulous research, drawing on extensive fieldwork, shows that the domination of the parliaments by parties aligned to the conflict does indeed tend to marginalise other identities. His findings provide plenty of food for thought for practitioners in the field of conflict resolution. In particular, they underline the need for care in the design of institutional arrangements for deeply divided societies, so as to minimise potentially negative consequences that priority for accommodation and reconciliation may have for other issues and for the practice of inclusion.”Adrian Guelke, Queen’s University Belfast, UK“Identity is a central organising principle of politics in the 21st century. In this impressive book Michael Potter shows that a focus on gender and minority ethnic identities in newly-formed post-conflict assemblies provides a unique litmus test of the robustness of democratic politics. He analyses the cases of Kosovo and Northern Ireland with rigour and considerable insight. This book makes a highly original and lasting contribution to theory and practice in post-conflict settings world-wide.”Yvonne Galligan, Dublin Institute of Technology, IrelandThis book examines inclusion in post-conflict legislatures, using Northern Ireland and Kosovo as case studies and gender and minority ethnicity as indicators. The analysis uses an adapted framework developed by Yvonne Galligan and Sara Clavero to measure inclusion across a range of factors associated with deliberative democratic principles. The logic is that political systems designed to accommodate communities in conflict will prioritise certain identities over others. The aim of the book is to investigate how identities not directly associated with a conflict fare in a political system designed to manage identities in conflict. The book looks comparatively at the conflicts in Kosovo and Northern Ireland, then discusses approaches to conflict management, describing how political institutions were designed in those contexts. The themes of women and minority identities in those conflicts are then explored with a view to examining the extent of inclusion in the Northern Ireland and Kosovo Assemblies.

“An excellent analysis of the complex dynamics of inclusion in post-conflict societies: theoretically grounded, empirically rich, and with a well-informed set of policy-relevant insights and recommendations with implications far beyond the cases of Kosovo and Northern Ireland.”Stefan Wolff, University of Birmingham, UK“Does the promotion of political accommodation between the contending parties in an ethno-nationalist conflict disadvantage other groups in society? This important question is at the heart of Michael Potter's nuanced study of post-settlement parliaments in Kosovo and Northern Ireland, in which he probes their record of representativeness, focusing on gender and ethnicity. His meticulous research, drawing on extensive fieldwork, shows that the domination of the parliaments by parties aligned to the conflict does indeed tend to marginalise other identities. His findings provide plenty of food for thought for practitioners in the field of conflict resolution. In particular, they underline the need for care in the design of institutional arrangements for deeply divided societies, so as to minimise potentially negative consequences that priority for accommodation and reconciliation may have for other issues and for the practice of inclusion.”Adrian Guelke, Queen’s University Belfast, UK“Identity is a central organising principle of politics in the 21st century. In this impressive book Michael Potter shows that a focus on gender and minority ethnic identities in newly-formed post-conflict assemblies provides a unique litmus test of the robustness of democratic politics. He analyses the cases of Kosovo and Northern Ireland with rigour and considerable insight. This book makes a highly original and lasting contribution to theory and practice in post-conflict settings world-wide.”Yvonne Galligan, Dublin Institute of Technology, IrelandThis book examines inclusion in post-conflict legislatures, using Northern Ireland and Kosovo as case studies and gender and minority ethnicity as indicators. The analysis uses an adapted framework developed by Yvonne Galligan and Sara Clavero to measure inclusion across a range of factors associated with deliberative democratic principles. The logic is that political systems designed to accommodate communities in conflict will prioritise certain identities over others. The aim of the book is to investigate how identities not directly associated with a conflict fare in a political system designed to manage identities in conflict. The book looks comparatively at the conflicts in Kosovo and Northern Ireland, then discusses approaches to conflict management, describing how political institutions were designed in those contexts. The themes of women and minority identities in those conflicts are then explored with a view to examining the extent of inclusion in the Northern Ireland and Kosovo Assemblies.

The development of innovative molecular techniques such as pulse-field gel electro­ phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva­ tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved in a variety of developmental, autoimmune, neoplastic and infectious disease processes. In the first of three sections, a series of papers outline the most currently used methods of mapping and isolating genes whose products are unknown. The papers, following, are devoted to specific gene systems whose dysregulation is likely to produce mutant or disease phenotypes.

Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog­ ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri­ ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol­ ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel workshop (held 4th-6th October 1998) that has been recorded and, in part, transcribed is being published as papers and discussions within Current Topics. This volume is the latest of a long series which documents the excitements of ground-breaking discoveries as well as the frustrations of our inability to fully understand the mechanisms leading to B cell neoplasia. The papers at the workshop are presented when possible in the sequence in which they were given. However, to facilitate the organization and reading of the book and to highlight gen­ eral topics and themes, the papers are organized into five sec­ tions: I B Cell and Plasma Cell Development II Chemokines and Chemokine Receptors III Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations IV Biology of Lymphomagenesis, B-CLL, Autoimmunity V Myeloma, Plasmacytomas and Related Subjects.

The papers in this book were presented at the 14th Mechanisms in B-cell Neoplasia meeting that was held in Bethesda, Maryland October 21-23, 1996. In 1995 the organizers decided that the format of the meeting would be changed and that specific topics relevant to B-cell neoplasia would be discussed. This year's topic is on the c-myc oncogene in B-cell neoplasia which has been discussed in virtually every previous meeting. Some of the presentations announced for the first time dramatic advances in our understanding of c-myc and because this subject has become highly complex it was thought that devoting the whole meeting to this theme would be appropriate. The book, therefore, repre­ sents a review of many aspects of the myc problem but by no means is truly comprehensive. In a recent Medline search there were 8,505 references to myc, fully illustrating the magnitude of the interest and depth of this field. The organizers of the meeting have each contributed review chapters that summarize different aspects of the meeting. We thank the National Cancer Institute for sponsoring this workshop and the staff of Cygnus, Inc. , for their outstanding organizational assistance. The organizers are most grateful to Vickie Rogers for assembling the book and dealing with the edi­ torialization of the manuscripts. MICHAEL POlTER FRITZ MELCHERS Table of Contents M. POlTER and K. B. MARCU The c-myc Story: Where We've Been, Where We Seem to be Going. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . I F.

The mouse was first used in immunological research by Paul Ehrlich in 1891 in an extraordinary series of experiments on the maternal transfer of antitoxic immunity. A short 22 years later in 1913 Halsey Bagg acquired a stock of albino mice from a commercial dealer and used them in a series of experiments on learning. Because he was interested in the genetics of intelligence, Halsey Bagg began breeding a pedigreed line of these mice that were subsequently named for him - Bagg Albino. Though Halsey Bagg is not credited with initiating the inbred strains of mice, his stock curiously has played an indisputably important role. Bagg Albinos were progenitors of the present day BALB/c family of sublines - the subject of this book. They were also used as one of the parents in the development of inbred strains A, CBA and C3H, three other very famous strains. Today the BALB/c mouse is among the five most widely used inbred strains in biomedical research and a particular favorite in immunology and infectious disease research. The hallmark of the BALB/c response to so many kinds of infections is susceptibility and sometimes an exaggerated susceptibility, but this paradoxically is not associated with immunodeficiency as BALB/c is an excellent responder to immuni­ zation. These characteristics have made the BALB/c mouse a model for identifying genes that determine susceptibility to infectious and neoplastic diseases. In 1985 the laboratory BALB/c mouse became 72 years old. The current filial generations are somewhere around 350 generations [MURPHY].

The present volume of "Current Topics in Microbiology and Immunology" is a series of papers on subjects that are relevant to the growing use of 'wild mice' in immunological, microbiological and genetical research. 'Wild mice' is a jargonistic term that is used chiefly in the laboratory to refer to the naturally living forms of house mice (Mus musculus) and also other species closely related to M. musculus. This group of species is designated by systematists as the genus Mus. Immunologists began 20 years ago to study the polymorphisms of 1mmunoglobulins and major histocompatibility complex antigens in wild mice. An extrordinary extension of the highly polymorphic array of phenotypes known in inbred mice was encountered. Breeding stocks of wild mice were brought into the laboratory. This included not only M. musculus but a)so many of the available species in the genus Mus-from Southeast Asia ~nd Europe. This availability led to other comparisons of 'wild' and inbred mice and the discovery of other new and interesting phenotypes and genotypes. It became apparent that inbred strains of mice provided only a limited window for viewing the genetic diversity of Mus musculus.

The fourth workshop on Mechanisms in B-Ce11 Neoplasia was held in Bethesda. Maryland. at the National Institutes of Health on March 24. 25 and 26. 1986. The meeting was attended by approximately 150 participants and 58 presentations were given. The purpose of these workshops and the yearly publications has been to provide a means for exchanging the rapidly developing information in this field and to bring maJor problems into focus. Edited trans- cripts of the 1983 and 1985 workshops were published by Editiones Roche Bas1e, Switzerland. Papers brought to the 1984 workshop were published in Current Topics in Microbiology and Immunology, Vol. 113. Numerous retrovira1 recombinant viral constructs are now in general use in a variety of test systems, both in vivo and in vitro. These are proving to have interesting bio10gica1-prQperties.------- Kecent1y developed systems for inducing B cell tumors are described: 1) The development of spontaneous ~-ce11 tumors in transgenic mice carrying deregulated mlGBP genes and the Ig heavy chain promoter; 2) a method for inducing *p1asmacytomas in BAL~/c mice with short latent periods of ca 70 days by infecting pristane treated mice with retroviruses carrying various types of deregulated mlGBP genes; 3) induction of pre-B cell tumors with erbB containing recombinant retroviruses; 4) induction of B-ce11 and other tumors by infection of neonates with recombinant retroviruses. Several retrovira1 constructs containing mlGBP sequences do not induce B-ce11 tumors in pristane conditioned mice *.

The papers in this book were presented at the 6th Workshop on Mechanisms in B-Cell Neoplasia, held in Bethesda, March 23-25, 1988. On alternate years this meeting is sponsored by the . ;. Basel Institute of Immunology in Basel, Switzerland and by the National Cancer Institute in Bethesda, and is attended by 100 to 150 parti­ cipants. This 6th workshop, like the preceding five, was characterized by intense and enthusiastic discussion which reflects, we think, the exciting growth and development of this field. It is quite clear, however, that despite many general advances an understanding of the precise underlying mechanisms in B-cell tumor development is not yet defined. Probably, there is no single mechanism for all the various forms of B-cell neo­ plastic development. Many different forms of B-cell neoplasms are known, and these are distinguished by several characteristics: 1) the stage of development attained by the tumor stem cells; 2) mode of growth (slow or fast); 3) association with natural or inductive etiologic agents and 4) specific and consistent mutational mechanisms such as retroviral insertion, chromosomal rearrangement. Those charac­ teristic forms which arise naturally in relatively high frequency or those tumors with hallmark properties which can be induced consistently are the models most frequently studied, e. g. , endemic Burkitt's lymphoma, follicular lymphoma, acute and chronic lymphocytic leukemia and mUltiple myeloma in man; bursal lymphoma in chickens; Abelson virus induced pre B cell lymphomas and plasmacytomas in mice and immunocytomas in rats. Each model system, has special problems and advantages.

Through numerous discussions with colleagues it became apparent that the time was right to begin a series of workshop-like meetings on myeloid tumorigenesis. Myeloid tumors are the nonlymphocytic tumors of the hematopoietic system which include tumors of the neutrophilic, monocytic, erythrocytic, basophilic (mast cell) and megakaryocytic lineages. Pioneering studies in myeloid tumorigenesis were initially made in chickens with the discovery of retroviruses that induce various kinds of myeloid tumors acutely (myelocytomatosis, myeloblastosis, and erythroblastosis). These avian retroviruses were subsequently shown to contain the oncogenes v-myb, v-~, v-~, v-erbA, or v-erbB. There have been dramatic advances in studying the pathogenesis of hematopoietic tumors in genetically defined mammalian systems. Many of the well developed model systems in inbred mice, have focused on T- and B-1ymphoma development. Although myeloid tumors have been found in mice, they have not been studied as intensively as lymphoid tumors. Possibly this is because myeloid tumors are less common than lymphoid tumors. Recently, there has been renewed interest in murine myeloid tumor systems.This focus has resulted from 1) the discovery of inbred strains of mice (e. g. BXH-2, AKXD- 23, SJL/J) that are highly susceptible to spontaneous or induced myeloid tumorigenesis; 2) establishment of transplantable murine myeloid tumors (e.

The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza­ tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma­ tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter­ parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.

On March 27, 1990, the National Cancer Institute sponsored a workshop on the epidemiology of multiple myeloma, held at the National Institutes of Health. This book comprises articles prepared by participants in this work­ shop. Discussed in these papers are: the descriptive and analytic epidemi­ ology, differences in risk factors between blacks and whites, monoclonal gammopathies and their progression, and hypotheses regarding the etiology and pathogenesis of multiple myeloma. Several epidemiologic research areas received particular attention during this workshop, and are reviewed in detail in this volume. There have been striking increases in the incidence of multiple myeloma over the past thirty years, especially among older individuals and blacks, which may not be entirely explained by changes in diagnostic capabilities. Occupational and environmental exposures have been associated with an increased risk of multiple myeloma, including farming exposures, occupational exposure to petroleum and rubber processing, exposure to ionizing radiation, and asso­ ciations with persistent virus infections. The most striking epidemiological finding is reflected in the differences in incidence rates of multiple myeloma which are twice as high in blacks as compared with whites. Further, since 1950 the mortality rates for multiple myeloma have quadrupled in blacks while doubling for whites. Among hematopoietic malignancies, multiple myeloma is the only one with increased incidence and mortality rates among blacks. 1\vo major possibilities for explaining ethnic/racial differences in suscepti­ bility to multiple myeloma are genetic and environmental factors.

Main topics covered: B-Cell Development; Immunoglobulin Gene Rearrangement; Multiple Myeloma, Plasmactomas; Lymphomas: B-CLL, Folli- cular Lymphomas BCL-2, BCL-1; Lymphomas: EBV, AIDS Associa- ted Lymphomas; Oncogenes and Transcriptional Factors (text to follow)

The 12th Workshop on "Mechanisms in B-Cell Neoplasia" continues this series of meetings on intriguing new developments in human and experimental B-cell tumors. The integration of knowledge from basic B-cell biology to the clinical problems of multiple myelomas, follicular lymphoma, mantle cell lymphoma and B-CLL present the challenges that were discussed in the meeting. The discussion focusses on: - Cellular components of the "myeloma clone" - Genomic instability in B-cells and B-cell tumors - The CD5 antigen and B1 cells - Regulation of cell cycle and apoptosis - Role of IL-6, BCL-2, BCL-1, myc in B-cell development