Michael Simons – författare

Angiogenesis and Cardiovascular Disease provides a comprehensive review of the basic scientific and clinical advances in the field of angiogenesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a single source. Topics addressed focus first on aspects of development and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic cardiovascular disease. Vascular development, endothelial cell biology, the vascular matrix, and growth factors are discussed. Up to date information on current clinical trials, and practical advice concerning application to cardiovascular therapeutic options, are also stressed.

Dive into DuckDB and start processing gigabytes of data with ease—all with no data warehouse. DuckDB is a cutting-edge SQL database that makes it incredibly easy to analyze big data sets right from your laptop. In  DuckDB in Action you'll learn everything you need to know to get the most out of this awesome tool, keep your data secure on prem, and save you hundreds on your cloud bill. From data ingestion to advanced data pipelines, you'll learn everything you need to get the most out of DuckDB—all through hands-on examples. Open up  DuckDB in Action and learn how to: Read and process data from CSV, JSON and Parquet sources both locally and remote Write analytical SQL queries, including aggregations, common table expressions, window functions, special types of joins, and pivot tables Use DuckDB from Python, both with SQL and its "Relational"-API, interacting with databases but also data frames Prepare, ingest and query large datasets Build cloud data pipelines Extend DuckDB with custom functionality Pragmatic and comprehensive,  DuckDB in Action introduces the DuckDB database and shows you how to use it to solve common data workflow problems. You won't need to read through pages of documentation—you'll learn as you work. Get to grips with DuckDB's unique SQL dialect, learning to seamlessly load, prepare, and analyze data using SQL queries. Extend DuckDB with both Python and built-in tools such as MotherDuck, and gain practical insights into building robust and automated data pipelines.   About the technology DuckDB makes data analytics fast and fun! You don't need to set up a Spark or run a cloud data warehouse just to process a few hundred gigabytes of data. DuckDB is easily embeddable in any data analytics application, runs on a laptop, and processes data from almost any source, including JSON, CSV, Parquet, SQLite and Postgres.

Document the architecture of your software easily with this highly practical, open-source template.Key FeaturesGet to grips with leveraging the features of arc42 to create insightful documentsLearn the concepts of software architecture documentation through real-world examplesDiscover techniques to create compact, helpful, and easy-to-read documentationBook DescriptionWhen developers document the architecture of their systems, they often invent their own specific ways of articulating structures, designs, concepts, and decisions. What they need is a template that enables simple and efficient software architecture documentation. arc42 by Example shows how it's done through several real-world examples.Each example in the book, whether it is a chess engine, a huge CRM system, or a cool web system, starts with a brief description of the problem domain and the quality requirements. Then, you'll discover the system context with all the external interfaces. You'll dive into an overview of the solution strategy to implement the building blocks and runtime scenarios. The later chapters also explain various cross-cutting concerns and how they affect other aspects of a program.What you will learnUtilize arc42 to document a system's physical infrastructureLearn how to identify a system's scope and boundariesBreak a system down into building blocks and illustrate the relationships between themDiscover how to describe the runtime behavior of a systemKnow how to document design decisions and their reasonsExplore the risks and technical debt of your systemWho this book is forThis book is for software developers and solutions architects who are looking for an easy, open-source tool to document their systems. It is a useful reference for those who are already using arc42. If you are new to arc42, this book is a great learning resource. For those of you who want to write better technical documentation will benefit from the general concepts covered in this book.

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.