Life course epidemiology is concerned with the origins of risk, resilience, and the processes of ageing, and how this information can be of value in a public health context - particularly for preventive health care. Its challenge is to discover, develop and analyse sources of data that cover many years of life, especially the early developmental period when, it is thought, some fundamental aspects of lifetime health begin. It also analyses genetic propensity and environmental exposures. The rapid development of life course epidemiology, in parallel with new work on developmental biology and the biology of ageing, has bought innovative and ingenious methods of data collection. These require new methodological techniques for the design of observational and quasi-experimental studies of life course pathways to adult health. This book describes these developments, together with arguments for improving the measurement of the social environment and its role in developing individual vulnerability or adaptation. The development of bio-bank large-scale population studies for the investigation of genetic effects is discussed, alongside the challenges this creates for the epidemiologist. The changing design of studies, increasing flow of longitudinal data, management of data, analytic challenges, timing, and both traditional and more recent methods of managing these features in the study of causality, are discussed.Life course epidemiology has an essential role in developing methods to evaluate precisely the impact of interacting developmental, environmental, and genetic effects, knowledge of which is fundamental for the design of effective prevention strategies in public health, as well as for the advancement of understanding in the broader spheres of health and medicine.

When Robert Brundle took the SS Harmatris to Russia with Convoy PQ8 he was 47 years of age. Both ship and master were veterans and had already sailed in convoys across the North Atlantic and to South Africa. The 5,395 ton coal fired ship, laden with 8,000 tons of armaments originally set sail on 27 November 1941 to join convoy PQ6 but encountered a fierce storm in which a lorry broke free in the hold and started a fierce blaze below decks. Despite valiant attempts to extinguish the fire the Harmatris was forced to return to Glasgow for repair. Having discharged its cargo, examined and repaired the holds, it restowed and finally put to sea again on 26 December. She was now to join PQ8 and Brundle was elected Convoy Commodore. Two minesweepers, a cruiser and two destroyers escorted the eight merchant vessels.On 8 January the convoy left Reykjavik bound for Murmansk. Harmatris was struck by two torpedoes in No 1 hold which caused flooding. A third torpedo struck her a few hours later and the crew evacuated to HMS Speedwell in attendance. A volunteer crew reboarded and Speedwell took the wounded ship in tow. During the night the same U Boat that had struck Harmatris sunk the destroyer Matabele with the loss of all but two of her crew. A tug eventually replaced Speedwell and the entire crew now returned to their still stricken vessel. On 18 January the ships were twice attacked by low flying Heinkels. The stricken Harmatris finally berthed in Murmansk at 0800 on 20 January. Once unloaded the battered ship entered dry dock on 10 February. The damage was considerable. In a temperature of 40 degrees below zero the crew set about the repairs. It was difficult to locate engine parts and local labor was scarce.During the following months the crew continued to work on the ship, food was scarce and the port was frequently bombed by the Luftwaffe. Several ships close to Harmatris were sunk. It was 21 July when the ship finally left for Archangel. She took aboard a cargo of 3,000 tons of steel pipes and on 13 September she was instructed to join a convoy of 20 ships, QP14 for her return voyage. On 19 September the minesweeper HMS Leda, steaming close by Harmartris, was torpedoed. The convoy was under almost continuous U Boat attack and suffered six losses. As a result of his heroic efforts to preserve his ship and crew Captain Brundle was awarded the OBE and the Lloyds War Medal. He died in 1960 at the age of 66.EPUB3: Reflowable

Life course epidemiology is concerned with the origins of risk, resilience, and the processes of ageing, and how this information can be of value in a public health context - particularly for preventive health care. Its challenge is to discover, develop and analyse sources of data that cover many years of life, especially the early developmental period when, it is thought, some fundamental aspects of lifetime health begin. It also analyses genetic propensity and environmental exposures. The rapid development of life course epidemiology, in parallel with new work on developmental biology and the biology of ageing, has bought innovative and ingenious methods of data collection. These require new methodological techniques for the design of observational and quasi-experimental studies of life course pathways to adult health. This book describes these developments, together with arguments for improving the measurement of the social environment and its role in developing individual vulnerability or adaptation. The development of bio-bank large-scale population studies for the investigation of genetic effects is discussed, alongside the challenges this creates for the epidemiologist. The changing design of studies, increasing flow of longitudinal data, management of data, analytic challenges, timing, and both traditional and more recent methods of managing these features in the study of causality, are discussed.Life course epidemiology has an essential role in developing methods to evaluate precisely the impact of interacting developmental, environmental, and genetic effects, knowledge of which is fundamental for the design of effective prevention strategies in public health, as well as for the advancement of understanding in the broader spheres of health and medicine.

When Robert Brundle took the SS Harmatris to Russia with Convoy PQ8 he was 47 years of age. Both ship and master were veterans and had already sailed in convoys across the North Atlantic and to South Africa. The 5,395 ton coal fired ship, laden with 8,000 tons of armaments originally set sail on 27 November 1941 to join convoy PQ6 but encountered a fierce storm in which a lorry broke free in the hold and started a fierce blaze below decks. Despite valiant attempts to extinguish the fire the Harmatris was forced to return to Glasgow for repair. Having discharged its cargo, examined and repaired the holds, it restowed and finally put to sea again on 26 December. She was now to join PQ8 and Brundle was elected Convoy Commodore. Two minesweepers, a cruiser and two destroyers escorted the eight merchant vessels.On 8 January the convoy left Reykjavik bound for Murmansk. Harmatris was struck by two torpedoes in No 1 hold which caused flooding. A third torpedo struck her a few hours later and the crew evacuated to HMS Speedwell in attendance. A volunteer crew reboarded and Speedwell took the wounded ship in tow. During the night the same U Boat that had struck Harmatris sunk the destroyer Matabele with the loss of all but two of her crew. A tug eventually replaced Speedwell and the entire crew now returned to their still stricken vessel. On 18 January the ships were twice attacked by low flying Heinkels. The stricken Harmatris finally berthed in Murmansk at 0800 on 20 January. Once unloaded the battered ship entered dry dock on 10 February. The damage was considerable. In a temperature of 40 degrees below zero the crew set about the repairs. It was difficult to locate engine parts and local labor was scarce.During the following months the crew continued to work on the ship, food was scarce and the port was frequently bombed by the Luftwaffe. Several ships close to Harmatris were sunk. It was 21 July when the ship finally left for Archangel. She took aboard a cargo of 3,000 tons of steel pipes and on 13 September she was instructed to join a convoy of 20 ships, QP14 for her return voyage. On 19 September the minesweeper HMS Leda, steaming close by Harmartris, was torpedoed. The convoy was under almost continuous U Boat attack and suffered six losses. As a result of his heroic efforts to preserve his ship and crew Captain Brundle was awarded the OBE and the Lloyds War Medal. He died in 1960 at the age of 66.EPUB3: Reflowable