Michael Wiese – författare

From humble beginnings in a small Midwestern town to being an integral part of the underground film scene of San Francisco in the ’60s. From studying with Balinese shadow puppet masters to presenting documentary screenings for the Dalai Lama. From producing the best parody ever of Star Wars to documenting the spiritual healing powers of Ayahuasca in the Peruvian jungle. From the hustle and bustle of film production in Hollywood to running the biggest “how-to” filmmaking press in the world, Michael has lived a life accompanied by countless paradigm thinkers such as Buckminster Fuller and Salvador Dalí, and he puts his heart and soul in every chapter to show you what the journey to true success, on every level of life, looks like.

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today''s pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors'' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.