Momiao Xiong – författare

Artificial Intelligence and Causal Inference address the recent development of relationships between artificial intelligence (AI) and causal inference. Despite significant progress in AI, a great challenge in AI development we are still facing is to understand mechanism underlying intelligence, including reasoning, planning and imagination. Understanding, transfer and generalization are major principles that give rise intelligence. One of a key component for understanding is causal inference. Causal inference includes intervention, domain shift learning, temporal structure and counterfactual thinking as major concepts to understand causation and reasoning. Unfortunately, these essential components of the causality are often overlooked by machine learning, which leads to some failure of the deep learning. AI and causal inference involve (1) using AI techniques as major tools for causal analysis and (2) applying the causal concepts and causal analysis methods to solving AI problems. The purpose of this book is to fill the gap between the AI and modern causal analysis for further facilitating the AI revolution. This book is ideal for graduate students and researchers in AI, data science, causal inference, statistics, genomics, bioinformatics and precision medicine.

Key Features:

Artificial Intelligence and Causal Inference address the recent development of relationships between artificial intelligence (AI) and causal inference. Despite significant progress in AI, a great challenge in AI development we are still facing is to understand mechanism underlying intelligence, including reasoning, planning and imagination. Understanding, transfer and generalization are major principles that give rise intelligence. One of a key component for understanding is causal inference. Causal inference includes intervention, domain shift learning, temporal structure and counterfactual thinking as major concepts to understand causation and reasoning. Unfortunately, these essential components of the causality are often overlooked by machine learning, which leads to some failure of the deep learning. AI and causal inference involve (1) using AI techniques as major tools for causal analysis and (2) applying the causal concepts and causal analysis methods to solving AI problems. The purpose of this book is to fill the gap between the AI and modern causal analysis for further facilitating the AI revolution. This book is ideal for graduate students and researchers in AI, data science, causal inference, statistics, genomics, bioinformatics and precision medicine.

Key Features:

Big Data in Omics and Imaging: Association Analysis addresses the recent development of association analysis and machine learning for both population and family genomic data in sequencing era. It is unique in that it presents both hypothesis testing and a data mining approach to holistically dissecting the genetic structure of complex traits and to designing efficient strategies for precision medicine. The general frameworks for association analysis and machine learning, developed in the text, can be applied to genomic, epigenomic and imaging data.

FEATURES

Bridges the gap between the traditional statistical methods and computational tools for small genetic and epigenetic data analysis and the modern advanced statistical methods for big data

Provides tools for high dimensional data reduction

Discusses searching algorithms for model and variable selection including randomization algorithms, Proximal methods and matrix subset selection

Provides real-world examples and case studies

Will have an accompanying website with R code

The book is designed for graduate students and researchers in genomics, bioinformatics, and data science. It represents the paradigm shift of genetic studies of complex diseases– from shallow to deep genomic analysis, from low-dimensional to high dimensional, multivariate to functional data analysis with next-generation sequencing (NGS) data, and from homogeneous populations to heterogeneous population and pedigree data analysis. Topics covered are: advanced matrix theory, convex optimization algorithms, generalized low rank models, functional data analysis techniques, deep learning principle and machine learning methods for modern association, interaction, pathway and network analysis of rare and common variants, biomarker identification, disease risk and drug response prediction.

Big Data in Omics and Imaging: Integrated Analysis and Causal Inference addresses the recent development of integrated genomic, epigenomic and imaging data analysis and causal inference in big data era. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), genome-wide expression studies (GWES), and epigenome-wide association studies (EWAS), the overall contribution of the new identified genetic variants is small and a large fraction of genetic variants is still hidden. Understanding the etiology and causal chain of mechanism underlying complex diseases remains elusive. It is time to bring big data, machine learning and causal revolution to developing a new generation of genetic analysis for shifting the current paradigm of genetic analysis from shallow association analysis to deep causal inference and from genetic analysis alone to integrated omics and imaging data analysis for unraveling the mechanism of complex diseases.

FEATURES

The book is designed for graduate students and researchers in genomics, epigenomics, medical image, bioinformatics, and data science. Topics covered are: mathematical formulation of causal inference, information geometry for causal inference, topology group and Haar measure, additive noise models, distance correlation, multivariate causal inference and causal networks, dynamic causal networks, multivariate and functional structural equation models, mixed structural equation models, causal inference with confounders, integer programming, deep learning and differential equations for wearable computing, genetic analysis of function-valued traits, RNA-seq data analysis, causal networks for genetic methylation analysis, gene expression and methylation deconvolution, cell –specific causal networks, deep learning for image segmentation and image analysis, imaging and genomic data analysis, integrated multilevel causal genomic, epigenomic and imaging data analysis.

Big Data in Omics and Imaging: Integrated Analysis and Causal Inference addresses the recent development of integrated genomic, epigenomic and imaging data analysis and causal inference in big data era. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), genome-wide expression studies (GWES), and epigenome-wide association studies (EWAS), the overall contribution of the new identified genetic variants is small and a large fraction of genetic variants is still hidden. Understanding the etiology and causal chain of mechanism underlying complex diseases remains elusive. It is time to bring big data, machine learning and causal revolution to developing a new generation of genetic analysis for shifting the current paradigm of genetic analysis from shallow association analysis to deep causal inference and from genetic analysis alone to integrated omics and imaging data analysis for unraveling the mechanism of complex diseases.

FEATURES

The book is designed for graduate students and researchers in genomics, epigenomics, medical image, bioinformatics, and data science. Topics covered are: mathematical formulation of causal inference, information geometry for causal inference, topology group and Haar measure, additive noise models, distance correlation, multivariate causal inference and causal networks, dynamic causal networks, multivariate and functional structural equation models, mixed structural equation models, causal inference with confounders, integer programming, deep learning and differential equations for wearable computing, genetic analysis of function-valued traits, RNA-seq data analysis, causal networks for genetic methylation analysis, gene expression and methylation deconvolution, cell –specific causal networks, deep learning for image segmentation and image analysis, imaging and genomic data analysis, integrated multilevel causal genomic, epigenomic and imaging data analysis.