The Guest Editors, coming from the Critical Care Medicine Department in the NIH, are the top thought leaders in the area of infections in critical care. Their topic selections in this issue reflect the most clinically relevant and current information. The issue specifically covers the following topics: Catheter-related bloodstream infections: special considerations in diagnosis in the ICU; Sepsis-How does the new definition help clinicians; Therapeutic drug monitoring of antibiotics; High containment pathogen preparation; Multidrug resistant gram negative infections and enterococcus; Strategies to prevent transmission of resistant organisms; Antibiotic Stewardship: What the intensivist should know; C. Difficile infection in the ICU; Immunocompromised critically ill; Rapid diagnostics: The use of procalcitonin; Respiratory viruses in the ICU: Significance of rhino/rsv updates/adenovirus metapneumovirus; Management of invasive fungal disease in the ICU; Inhaled/Nebulized antibiotics. Infectious disease physicians and intensivists will be armed with the information they need to diagnose and treat patients with infections in the ICU.

The Guest Editors, coming from the Critical Care Medicine Department in the NIH, are the top thought leaders in the area of infections in critical care. Their topic selections in this issue reflect the most clinically relevant and current information. The issue specifically covers the following topics: Catheter-related bloodstream infections: special considerations in diagnosis in the ICU; Sepsis-How does the new definition help clinicians; Therapeutic drug monitoring of antibiotics; High containment pathogen preparation; Multidrug resistant gram negative infections and enterococcus; Strategies to prevent transmission of resistant organisms; Antibiotic Stewardship: What the intensivist should know; C. Difficile infection in the ICU; Immunocompromised critically ill; Rapid diagnostics: The use of procalcitonin; Respiratory viruses in the ICU: Significance of rhino/rsv updates/adenovirus metapneumovirus; Management of invasive fungal disease in the ICU; Inhaled/Nebulized antibiotics. Infectious disease physicians and intensivists will be armed with the information they need to diagnose and treat patients with infections in the ICU.

In this issue of Infectious Disease Clinics of North America, guest editors Drs. Naomi P. O'Grady and Sameer Kadri bring their considerable expertise to the topic of Complex Infectious Diseases Issues in the Intensive Care Unit. Affected immunity of patients with COVID-19 has made management of complex infectious diseases in the intensive care unit more important than ever. This issue provides key updates for managing these complex infectious diseases and includes current clinical information for COVID-19 patients, making this a state-of-the-art collection of review articles for practicing infectious disease physicians.

Catheter-Related Infections in the Critically Ill provides an overview from an international perspective on intravascular catheters and the risk of infection. This volume highlights: The purpose of this book is to provide the practitioner with the most interesting and useful data in the field of catheter-related infection. It is hoped that the strategies to prevent infection detailed by the authors will be implemented and have a measurable impact in decreasing rates of infection in the intensive care unit setting.

The Guest Editors, coming from the Critical Care Medicine Department in the NIH, are the top thought leaders in the area of infections in critical care. Their topic selections in this issue reflect the most clinically relevant and current information. The issue specifically covers the following topics: Catheter-related bloodstream infections: special considerations in diagnosis in the ICU; Sepsis-How does the new definition help clinicians; Therapeutic drug monitoring of antibiotics; High containment pathogen preparation; Multidrug resistant gram negative infections and enterococcus; Strategies to prevent transmission of resistant organisms; Antibiotic Stewardship: What the intensivist should know; C. Difficile infection in the ICU; Immunocompromised critically ill; Rapid diagnostics: The use of procalcitonin; Respiratory viruses in the ICU: Significance of rhino/rsv updates/adenovirus metapneumovirus; Management of invasive fungal disease in the ICU; Inhaled/Nebulized antibiotics. Infectious disease physicians and intensivists will be armed with the information they need to diagnose and treat patients with infections in the ICU.

The Guest Editors, coming from the Critical Care Medicine Department in the NIH, are the top thought leaders in the area of infections in critical care. Their topic selections in this issue reflect the most clinically relevant and current information. The issue specifically covers the following topics: Catheter-related bloodstream infections: special considerations in diagnosis in the ICU; Sepsis-How does the new definition help clinicians; Therapeutic drug monitoring of antibiotics; High containment pathogen preparation; Multidrug resistant gram negative infections and enterococcus; Strategies to prevent transmission of resistant organisms; Antibiotic Stewardship: What the intensivist should know; C. Difficile infection in the ICU; Immunocompromised critically ill; Rapid diagnostics: The use of procalcitonin; Respiratory viruses in the ICU: Significance of rhino/rsv updates/adenovirus metapneumovirus; Management of invasive fungal disease in the ICU; Inhaled/Nebulized antibiotics. Infectious disease physicians and intensivists will be armed with the information they need to diagnose and treat patients with infections in the ICU.

In this issue of Infectious Disease Clinics of North America, guest editors Drs. Naomi P. O'Grady and Sameer Kadri bring their considerable expertise to the topic of Complex Infectious Diseases Issues in the Intensive Care Unit. Affected immunity of patients with COVID-19 has made management of complex infectious diseases in the intensive care unit more important than ever. This issue provides key updates for managing these complex infectious diseases and includes current clinical information for COVID-19 patients, making this a state-of-the-art collection of review articles for practicing infectious disease physicians.

Catheter-Related Infections in the Critically Ill provides an overview from an international perspective on intravascular catheters and the risk of infection. This volume highlights: The purpose of this book is to provide the practitioner with the most interesting and useful data in the field of catheter-related infection. It is hoped that the strategies to prevent infection detailed by the authors will be implemented and have a measurable impact in decreasing rates of infection in the intensive care unit setting.