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4 produkter
4 produkter
Inbunden, Engelska, 2001
1 678 kr
Skickas inom 10-15 vardagar
This book looks at the role of proteases, which are enzymes that digest proteins, and the various roles that proteases play in the development of neurodegenerative diseases such as Alzheimer's disease, ALS, epilepsy, multiple sclerosis, as well as numerous other neuromuscular diseases.
E-bok
PDF, Engelska, 20072 036 kr
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Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.
E-bok
PDF, Engelska, 201046 kr
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This volume of the Handbook of Neurochemistry and Molecular Neurobiology characterizes pathologies resulting from traumatic brain and spinal cord injury as well as various neurodegenerative diseases, demyelinating diseases, viral infection, nervous system tumors, and neuropathies. Special attention is given to mechanisms and pathways of cell death in the brain. The contributors explore and comment on current treatment strategies including facilitating neuroprotection and regeneration and treatment using stem cells.
Häftad, Engelska, 2010
1 678 kr
Skickas inom 10-15 vardagar
This book looks at the role of proteases, which are enzymes that digest proteins, and the various roles that proteases play in the development of neurodegenerative diseases such as Alzheimer's disease, ALS, epilepsy, multiple sclerosis, as well as numerous other neuromuscular diseases.