Navin Kumar Verma – författare

This volume discusses the latest developments in cellular, molecular, biochemical, and imaging assays to study the biology and functions of T-cells. The chapters in this book cover topics such as LFA-1/ICAM-1 interactions in T-cell motility; using 3D-SIM to dissect signaling cross-talks in motile T-cells; GapmeR-mediated gene silencing in motile T-cells; activity of cellular kinases in migrating T-cells; and computational analysis of protein-protein interactions in motile T-cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, T-Cell Motility: Methods and Protocols is an essential resource for graduate students, postdoctoral fellows, and principal investigators working in the fields ofimmunology, T-cell biology, biochemistry, molecular biology, and imaging.

This contributed book provides a comprehensive exploration of chemical and immunological strategies in cancer therapeutics, emphasizing precision medicine approaches for targeted and effective treatments. It integrates cutting-edge advancements in drug discovery, covering a diverse range of anticancer agents, from natural compounds and metal-based complexes to synthetic inhibitors and nanocarriers.The chapters cover topics such as the rational design and optimization of cancer therapeutics, employing molecular modeling, structure-activity relationship analysis, and AI-driven drug discovery. Additionally, the book highlights immunological interventions, such as immune checkpoint inhibitors and host-directed therapies, showcasing their growing relevance in personalized cancer treatment. Readers will discover diverse perspectives from expert contributing authors, offering a balanced perspective on the potential and limitations of these compounds in cancer therapeutics.This book is intended for researchers, academics, clinicians, and industry professionals engaged in oncology, pharmacology, medicinal chemistry, and natural product research. By combining theoretical insights with practical applications, it aims to advance understanding, inspire innovation, and facilitate the translation of promising cancer therapeutics from the lab to clinical settings.