Niall M Adams – författare
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Inbunden, Engelska, 2014
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There is increasing pressure to protect computer networks against unauthorized intrusion, and some work in this area is concerned with engineering systems that are robust to attack. However, no system can be made invulnerable. Data Analysis for Network Cyber-Security focuses on monitoring and analyzing network traffic data, with the intention of preventing, or quickly identifying, malicious activity.Such work involves the intersection of statistics, data mining and computer science. Fundamentally, network traffic is relational, embodying a link between devices. As such, graph analysis approaches are a natural candidate. However, such methods do not scale well to the demands of real problems, and the critical aspect of the timing of communications events is not accounted for in these approaches.This book gathers papers from leading researchers to provide both background to the problems and a description of cutting-edge methodology. The contributors are from diverse institutions and areas of expertise and were brought together at a workshop held at the University of Bristol in March 2013 to address the issues of network cyber security. The workshop was supported by the Heilbronn Institute for Mathematical Research.
Häftad, Engelska, 2001
559 kr
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ThesearetheproceedingsofthefourthbiennialconferenceintheIntelligentData Analysisseries. TheconferencetookplaceinCascais,Portugal,13-15September 2001. Thethemeofthisconferenceseriesistheuseofcomputersinintelligent waysindataanalysis,includingtheexplorationofintelligentprogramsfordata analysis. Dataanalytictoolscontinuetodevelop,drivenbythecomputerrevo- tion. Methodswhichwouldhaverequiredunimaginableamountsofcomputing power,andwhichwouldhavetakenyearstoreachaconclusion,cannowbe appliedwitheaseandvirtuallyinstantly. Suchmethodsarebeingdevelopedby avarietyofintellectualcommunities,includingstatistics,arti?cialintelligence, neuralnetworks,machinelearning,datamining,andinteractivedynamicdata visualization. Thisconferenceseriesseekstobringtogetherresearchersstudying theuseofintelligentdataanalysisinthesevariousdisciplines,tostimulate- teractionsothateachdisciplinemaylearnfromtheothers. Soastoencourage suchinteraction,wedeliberatelykepttheconferencetoasingletrackmeeting. Thismeantthat,ofthealmost150submissionswereceived,wewereableto selectonly23fororalpresentationand16forposterpresentation.Inaddition tothesecontributedpapers,therewasakeynoteaddressfromDarylPregibon, invitedpresentationsfromKatharinaMorik,RolfBackhofen,andSunilRao,and aspecial'datachallenge'session,whereresearchersdescribedtheirattemptsto analyseachallengingdatasetprovidedbyPaulCohen. Thisacceptancerate enabledustoensureahighqualityconference,whilealsopermittingustop- videgoodcoverageofthevarioustopicssubsumedwithinthegeneralheading ofintelligentdataanalysis. Wewouldliketoexpressourthanksandappreciationtoeveryoneinvolved intheorganizationofthemeetingandtheselectionofthepapers. Itisthe behind-the-scenese?ortswhichensurethesmoothrunningandsuccessofany conference. Wewouldalsoliketoexpressourgratitudetothesponsors:Fundac" ,ao paraaCienciaeaTecnologia,Minist'eriodaCienciaedaTecnologia,Faculdade deCienciaseTecnologia,UniversidadeNovadeLisboa,Funda,c"aoCalousteG- benkianandIPEInvestimentoseParticipac" ,oesEmpresariais,S. A. September2001 FrankHo?mann DavidJ. Hand NiallAdams GabrielaGuimaraes DougFisher Organization IDA2001wasorganizedbythedepartmentofComputerScience,NewUniversity ofLisbon. ConferenceCommittee GeneralChair: DouglasFisher(VanderbiltUniversity,USA) ProgramChairs: DavidJ.Hand(ImperialCollege,UK) NiallAdams(ImperialCollege,UK) ConferenceChair: GabrielaGuimaraes(NewUniversityofLisbon,Portugal) PublicityChair: FrankHoppner(Univ. ofAppl. SciencesEmden,Germany) PublicationChair: FrankHo?mann(RoyalInstituteofTechnology,Sweden) LocalChair: FernandoMoura-Pires(UniversityofEvora,Portugal) AreaChairs: RobertaSiciliano(UniversityofNaples,Italy) ArnoSiebes(CWI,TheNetherlands) PavelBrazdil(UniversityofPorto,Portugal) ProgramCommittee NiallAdams(ImperialCollege,UK) PieterAdriaans(Syllogic,TheNetherlands) RussellAlmond(EducationalTestingService,USA) ThomasBack(InformatikCentrumDortmund,Germany) RiccardoBellazzi(UniversityofPavia,Italy) MichaelBerthold(Tripos,USA) LiuBing(NationalUniversityofSingapore) PaulCohen(UniversityofMassachusetts,USA) PaulDarius(LeuvenUniversity,Belgium) FazelFamili(NationalResearchCouncil,Canada) DouglasFisher(VanderbiltUniversity,USA) KarlFroeschl(UniversityofVienna,Austria) AlexGammerman(RoyalHolloway,UK) AdolfGrauel(UniversityofPaderborn,Germany) GabrielaGuimaraes(NewUniversityofLisbon,Portugal) LawrenceO. Hall(UniversityofSouthFlorida,USA) FrankHo?mann(RoyalInstituteofTechnology,Sweden) AdeleHowe(ColoradoStateUniversity,USA) Klaus-PeterHuber(SASInstitute,Germany) DavidJensen(UniversityofMassachusetts,USA) JoostKok(LeidenUniversity,TheNetherlands) RudolfKruse(UniversityofMagdeburg,Germany) FrankKlawonn(UniversityofAppliedSciencesEmden,Germany) VIII Organization HansLenz(FreeUniversityofBerlin,Germany) DavidMadigan(Soliloquy,USA) RainerMalaka(EuropeanMediaLaboratory,Germany) HeikkiMannila(Nokia,Finland) FernandoMouraPires(UniversityofEvora,Portugal) SusanaNascimento(UniversityofLisbon,Portugal) WayneOldford(UniversityofWaterloo,Canada) AlbertPrat(TechnicalUniversityofCatalunya,Spain) PeterProtzel(TechnicalUniversityChemnitz,Germany) GiacomodellaRiccia(UniversityofUdine,Italy) RosannaSchiavo(UniversityofVenice,Italy) KaisaSere(AboAkademiUniversity,Finland) RobertaSiciliano(UniversityofNaples,Italy) RosariaSilipo(Nuance,USA) FloorVerdenius(ATO-DLO,TheNetherlands) StefanWrobel(UniversityofMagdeburg,Germany) HuiXiaoLiu(BrunelUniversity,UK) NevinZhang(HongKongUniversityofScienceandTechnology,HongKong) SponsoringInstitutions Fundac" ,aoparaaCienciaeaTecnologia,Minist'eriodaCienciaedaTecnologia FaculdadedeCienciaseTecnologia,UniversidadeNovadeLisboa Fundac" ,aoCalousteGulbenkian IPEInvestimentoseParticipac" ,15September 2001.Thethemeofthisconferenceseriesistheuseofcomputersinintelligent waysindataanalysis,includingtheexplorationofintelligentprogramsfordata analysis. Dataanalytictoolscontinuetodevelop,drivenbythecomputerrevo- tion. Methodswhichwouldhaverequiredunimaginableamountsofcomputing power,andwhichwouldhavetakenyearstoreachaconclusion,cannowbe appliedwitheaseandvirtuallyinstantly. Suchmethodsarebeingdevelopedby avarietyofintellectualcommunities,includingstatistics,arti?cialintelligence, neuralnetworks,machinelearning,datamining,andinteractivedynamicdata visualization. Thisconferenceseriesseekstobringtogetherresearchersstudying theuseofintelligentdataanalysisinthesevariousdisciplines,tostimulate- teractionsothateachdisciplinemaylearnfromtheothers. Soastoencourage suchinteraction,wedeliberatelykepttheconferencetoasingletrackmeeting. Thismeantthat,ofthealmost150submissionswereceived,wewereableto selectonly23fororalpresentationand16forposterpresentation.Inaddition tothesecontributedpapers,therewasakeynoteaddressfromDarylPregibon, invitedpresentationsfromKatharinaMorik,RolfBackhofen,andSunilRao,and aspecial'datachallenge'session,whereresearchersdescribedtheirattemptsto analyseachallengingdatasetprovidedbyPaulCohen. Thisacceptancerate enabledustoensureahighqualityconference,whilealsopermittingustop- videgoodcoverageofthevarioustopicssubsumedwithinthegeneralheading ofintelligentdataanalysis. Wewouldliketoexpressourthanksandappreciationtoeveryoneinvolved intheorganizationofthemeetingandtheselectionofthepapers. Itisthe behind-the-scenese?ortswhichensurethesmoothrunningandsuccessofany conference. Wewouldalsoliketoexpressourgratitudetothesponsors:Fundac" cao paraaCienciaeaTecnologia,Minist'eriodaCienciaedaTecnologia,Faculdade deCienciaseTecnologia,UniversidadeNovadeLisboa,Fundacc"aoCalousteG- benkianandIPEInvestimentoseParticipac" coesEmpresariais,S. A. September2001 FrankHo?mann DavidJ. Hand NiallAdams GabrielaGuimaraes DougFisher Organization IDA2001wasorganizedbythedepartmentofComputerScience,NewUniversity ofLisbon. ConferenceCommittee GeneralChair: DouglasFisher(VanderbiltUniversity,USA) ProgramChairs: DavidJ.Hand(ImperialCollege,UK) NiallAdams(ImperialCollege,UK) ConferenceChair: GabrielaGuimaraes(NewUniversityofLisbon,Portugal) PublicityChair: FrankHoppner(Univ. ofAppl. SciencesEmden,Germany) PublicationChair: FrankHo?mann(RoyalInstituteofTechnology,Sweden) LocalChair: FernandoMoura-Pires(UniversityofEvora,Portugal) AreaChairs: RobertaSiciliano(UniversityofNaples,Italy) ArnoSiebes(CWI,TheNetherlands) PavelBrazdil(UniversityofPorto,Portugal) ProgramCommittee NiallAdams(ImperialCollege,UK) PieterAdriaans(Syllogic,TheNetherlands) RussellAlmond(EducationalTestingService,USA) ThomasBack(InformatikCentrumDortmund,Germany) RiccardoBellazzi(UniversityofPavia,Italy) MichaelBerthold(Tripos,USA) LiuBing(NationalUniversityofSingapore) PaulCohen(UniversityofMassachusetts,USA) PaulDarius(LeuvenUniversity,Belgium) FazelFamili(NationalResearchCouncil,Canada) DouglasFisher(VanderbiltUniversity,USA) KarlFroeschl(UniversityofVienna,Austria) AlexGammerman(RoyalHolloway,UK) AdolfGrauel(UniversityofPaderborn,Germany) GabrielaGuimaraes(NewUniversityofLisbon,Portugal) LawrenceO. Hall(UniversityofSouthFlorida,USA) FrankHo?mann(RoyalInstituteofTechnology,Sweden) AdeleHowe(ColoradoStateUniversity,USA) Klaus-PeterHuber(SASInstitute,Germany) DavidJensen(UniversityofMassachusetts,USA) JoostKok(LeidenUniversity,TheNetherlands) RudolfKruse(UniversityofMagdeburg,Germany) FrankKlawonn(UniversityofAppliedSciencesEmden,Germany) VIII Organization HansLenz(FreeUniversityofBerlin,Germany) DavidMadigan(Soliloquy,USA) RainerMalaka(EuropeanMediaLaboratory,Germany) HeikkiMannila(Nokia,Finland) FernandoMouraPires(UniversityofEvora,Portugal) SusanaNascimento(UniversityofLisbon,Portugal) WayneOldford(UniversityofWaterloo,Canada) AlbertPrat(TechnicalUniversityofCatalunya,Spain) PeterProtzel(TechnicalUniversityChemnitz,Germany) GiacomodellaRiccia(UniversityofUdine,Italy) RosannaSchiavo(UniversityofVenice,Italy) KaisaSere(AboAkademiUniversity,Finland) RobertaSiciliano(UniversityofNaples,Italy) RosariaSilipo(Nuance,USA) FloorVerdenius(ATO-DLO,TheNetherlands) StefanWrobel(UniversityofMagdeburg,Germany) HuiXiaoLiu(BrunelUniversity,UK) NevinZhang(HongKongUniversityofScienceandTechnology,HongKong) SponsoringInstitutions Fundac" caoparaaCienciaeaTecnologia,Minist'eriodaCienciaedaTecnologia FaculdadedeCienciaseTecnologia,UniversidadeNovadeLisboa Fundac" caoCalousteGulbenkian IPEInvestimentoseParticipac" coesEmpresariais,S.A. TableofContents TheFourthInternationalSymposiumonIntelligentData Analysis FeatureCharacterizationinScienti?cDatasets...1 ElizabethBradley(UniversityofColorado),NancyCollins(University ofColorado),W. PhilipKegelmeyer(SandiaNationalLaboratories) RelevanceFeedbackintheBayesianNetworkRetrievalModel: AnApproachBasedonTermInstantiation...13 LuisM. deCampos(UniversityofGranada),JuanM. Fernan ' dez-Luna (UniversityofJa'en),JuanF. Huete(UniversityofGranada) GeneratingFuzzySummariesfromFuzzyMultidimensionalDatabases...24 AnneLaurent(Universit'ePierreetMarieCurie) AMixture-of-ExpertsFrameworkforLearningfromImbalancedData Sets...34 AndrewEstabrooks(IBM),NathalieJapkowicz(UniversityofOttawa) PredictingTime-VaryingFunctionswithLocalModels...44 AchimLewandowski(ChemnitzUniversity),PeterProtzel(Chemnitz University) BuildingModelsofEcologicalDynamicsUsingHMMBasedTemporal DataClustering-APreliminaryStudy...53 CenLi(TennesseeStateUniversity),GautamBiswas(Vanderbilt University),MikeDale(Gri?thUniversity),PatDale(Gri?th University) TaggingwithSmallTrainingCorpora...63 NunoC. Marques(UniversidadeAberta),GabrielPereiraLopes (Centria) ASearchEngineforMorphologicallyComplexLanguages...73 UdoHahn(UniversitatFreiburg),MartinHoneck(Universitat sklinikum Freiburg),StefanSchulz(Universitat oppner(Univ. ofAppl. SciencesEmden,Germany) PublicationChair: FrankHo?mann(RoyalInstituteofTechnology,Sweden) LocalChair: FernandoMoura-Pires(UniversityofEvora,Portugal) AreaChairs: RobertaSiciliano(UniversityofNaples,Italy) ArnoSiebes(CWI,TheNetherlands) PavelBrazdil(UniversityofPorto,Portugal) ProgramCommittee NiallAdams(ImperialCollege,UK) PieterAdriaans(Syllogic,TheNetherlands) RussellAlmond(EducationalTestingService,USA) ThomasBack(InformatikCentrumDortmund,Germany) RiccardoBellazzi(UniversityofPavia,Italy) MichaelBerthold(Tripos,USA) LiuBing(NationalUniversityofSingapore) PaulCohen(UniversityofMassachusetts,USA) PaulDarius(LeuvenUniversity,Belgium) FazelFamili(NationalResearchCouncil,Canada) DouglasFisher(VanderbiltUniversity,USA) KarlFroeschl(UniversityofVienna,Austria) AlexGammerman(RoyalHolloway,UK) AdolfGrauel(UniversityofPaderborn,Germany) GabrielaGuimaraes(NewUniversityofLisbon,Portugal) LawrenceO. Hall(UniversityofSouthFlorida,USA) FrankHo?mann(RoyalInstituteofTechnology,Sweden) AdeleHowe(ColoradoStateUniversity,USA) Klaus-PeterHuber(SASInstitute,Germany) DavidJensen(UniversityofMassachusetts,USA) JoostKok(LeidenUniversity,TheNetherlands) RudolfKruse(UniversityofMagdeburg,Germany) FrankKlawonn(UniversityofAppliedSciencesEmden,Germany) VIII Organization HansLenz(FreeUniversityofBerlin,Germany) DavidMadigan(Soliloquy,USA) RainerMalaka(EuropeanMediaLaboratory,Germany) HeikkiMannila(Nokia,Finland) FernandoMouraPires(UniversityofEvora,Portugal) SusanaNascimento(UniversityofLisbon,Portugal) WayneOldford(UniversityofWaterloo,Canada) AlbertPrat(TechnicalUniversityofCatalunya,Spain) PeterProtzel(TechnicalUniversityChemnitz,Germany) GiacomodellaRiccia(UniversityofUdine,Italy) RosannaSchiavo(UniversityofVenice,Italy) KaisaSere(AboAkademiUniversity,Finland) RobertaSiciliano(UniversityofNaples,Italy) RosariaSilipo(Nuance,USA) FloorVerdenius(ATO-DLO,TheNetherlands) StefanWrobel(UniversityofMagdeburg,Germany) HuiXiaoLiu(BrunelUniversity,UK) NevinZhang(HongKongUniversityofScienceandTechnology,HongKong) SponsoringInstitutions Fundac" caoparaaCienciaeaTecnologia,Minist'eriodaCienciaedaTecnologia FaculdadedeCienciaseTecnologia,UniversidadeNovadeLisboa Fundac" caoCalousteGulbenkian IPEInvestimentoseParticipac" coesEmpresariais,S.A. TableofContents TheFourthInternationalSymposiumonIntelligentData Analysis FeatureCharacterizationinScienti?cDatasets...1 ElizabethBradley(UniversityofColorado),NancyCollins(University ofColorado),W. PhilipKegelmeyer(SandiaNationalLaboratories) RelevanceFeedbackintheBayesianNetworkRetrievalModel: AnApproachBasedonTermInstantiation...13 LuisM. deCampos(UniversityofGranada),JuanM. Fernan ' dez-Luna (UniversityofJa'en),JuanF. Huete(UniversityofGranada) GeneratingFuzzySummariesfromFuzzyMultidimensionalDatabases...24 AnneLaurent(Universit'ePierreetMarieCurie) AMixture-of-ExpertsFrameworkforLearningfromImbalancedData Sets...34 AndrewEstabrooks(IBM),NathalieJapkowicz(UniversityofOttawa) PredictingTime-VaryingFunctionswithLocalModels...44 AchimLewandowski(ChemnitzUniversity),PeterProtzel(Chemnitz University) BuildingModelsofEcologicalDynamicsUsingHMMBasedTemporal DataClustering-APreliminaryStudy...53 CenLi(TennesseeStateUniversity),GautamBiswas(Vanderbilt University),MikeDale(Gri?thUniversity),PatDale(Gri?th University) TaggingwithSmallTrainingCorpora...63 NunoC. Marques(UniversidadeAberta),GabrielPereiraLopes (Centria) ASearchEngineforMorphologicallyComplexLanguages...73 UdoHahn(UniversitatFreiburg),MartinHoneck(Universitat sklinikum Freiburg),StefanSchulz(Universitat sklinikumFreiburg) ErrorsDetectionandCorrectioninLargeScaleDataCollecting...84 RenatoBruni(Universit'adiRoma),AntonioSassano(Universit'adi Roma) X TableofContents ANewFrameworktoAssessAssociationRules ...95 FernandoBerzal(UniversityofGranada),IgnacioBlanco(University ofGranada),DanielS'anchez(UniversityofGranada), Mar'?a-AmparoVila(UniversityofGranada) CommunitiesofInterest ...105 CorinnaCortes(AT&TShannonResearchLabs),DarylPregibon (AT&TShannonResearchLabs),ChrisVolinsky(AT&TShannon ResearchLabs) AnEvaluationofGradingClassi?ers ...115 AlexanderK. Seewald(AustrianResearchInstituteforArti?cial Intelligence),JohannesFur nkranz(AustrianResearchInstitutefor Arti?cialIntelligence) FindingInformativeRulesinIntervalSequences ...125 FrankHoppner(UniversityofAppliedSciencesEmden), FrankKlawonn(UniversityofAppliedSciencesEmden) Correlation-BasedandContextualMerit-BasedEnsembleFeature Selection...135 SeppoPuuronen(UniversityofJyvaskyla),AlexeyTsymbal(University ofJyvaskyla),IrynaSkrypnyk(UniversityofJyvas kyla) NonmetricMultidimensionalScalingwithNeuralNetworks...145 MichielC. vanWezel(UniversiteitLeiden),WalterA.Kosters (UniversiteitLeiden),PetervanderPutten(UniversiteitLeiden), JoostN. Kok(UniversiteitLeiden) FunctionalTreesforRegression...156 Joao " Gama(UniversityofPorto) DataMiningwithProductsofTrees...167 Jos'eTom'eA. S. Ferreira(ImperialCollege),DavidG. T. Denison (ImperialCollege),DavidJ. Hand(ImperialCollege) 3 SBagging:FastClassi?erInductionMethodwithSubsamplingand Bagging ...177 MasahiroTerabe(MitshibishiResearchInstitute,Inc. ),TakashiWashio (I. S. I. R. ,OsakaUniversity),HiroshiMotoda(I. S. I. R.
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Häftad, Engelska, 2009
559 kr
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The general theme of the Intelligent Data Analysis (IDA) Symposia is the - telligent use of computers in complex data analysis problems. The ?eld has matured su?ciently that some re-considerationof our objectives was required in order to retain the distinctiveness of IDA. Thus, in addition to the more tra- tional algorithm- and application-oriented submissions, we sought submissions that speci?cally focus on aspects of the data analysis process. For example, - teractive tools to guide and support data analysis in complex scenarios. With the increasingavailabilityofautomaticallycollecteddata,toolsthatintelligently support and assist human analysts are becoming important. IDA-09, the 8th International Symposium on Intelligent Data Analysis, took place in Lyon from August 31 to September 2, 2009. The invited speakers were PaulCohen(UniversityofArizona,USA)andPabloJensen(ENSLyon,France). The meeting received more than 80 submissions. The Programme Committee selected 33 submissions for publication: 18 for full oral presentation, and 15 for poster and short oralpresentation. Eachcontribution was evaluated by three expertsandhas beenallocated12pagesintheproceedings.Theacceptedpapers cover a broad range of topics and applications, and include contributions on the re?ned focus of IDA.
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Häftad, Engelska, 2010
559 kr
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The background to IDA 2010, the 9th International Symposium on Intelligent DataAnalysis(IDA),is ratherunusual. Previously,thesymposiawereheldbi- nially at European venues. Over this time, the IDA Symposium had established an identity, a dedicated group of Program Committee members, and a regular audience. However, this success had come at a cost to the original ambitions for the symposium - concerned with interfacing AI, statistics and computer science for important and di?cult real-world data analysis problems - being comp- mised in favor of more standard data mining content. IDA 2010 was organized explicitly to re-align the IDA Symposia series with a set of objectives evolved from the original ambitions. This should be construed not as a criticism of r- tine data mining research but rather as an admission that the IDA symposium had taken the path of least resistance with respect to the call for papers and the reviewing process. This is the proceedings volume of IDA 2010, a special event held only a year after the eighth symposium in an attempt to revitalize the area of IDA. There were two major changes compared to previous symposia.First, the Call for - pers (CfP) was completely rewritten, placing great emphasis on algorithms and systems thatsupportmodelling andanalysisofcomplex real-worldsystems. - reover, the CfP explicitly discouraged submissions that might be characterized as "incrementaladvances indata mining algorithms. "Second, the reviewing- chanism was extended to include a "senior ProgrammeCommittee," in response to perceived shortcomings in the existing reviewing process.
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Inbunden, Engelska, 2010
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This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.
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This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.
Häftad, Engelska, 2014
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This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.