Niels Gregersen – författare

Simulation and modeling using numerical methods is one of the key instruments in any scientific work. In the field of photonics, a wide range of numerical methods are used for studying both fundamental optics and applications such as design, development, and optimization of photonic components. Modeling is key for developing improved photonic devices and reducing development time and cost.Choosing the appropriate computational method for a photonics modeling problem requires a clear understanding of the pros and cons of the available numerical methods. Numerical Methods in Photonics presents six of the most frequently used methods: FDTD, FDFD, 1+1D nonlinear propagation, modal method, Green’s function, and FEM. After an introductory chapter outlining the basics of Maxwell’s equations, the book includes self-contained chapters that focus on each of the methods. Each method is accompanied by a review of the mathematical principles in which it is based, along with sample scripts, illustrative examples of characteristic problem solving, and exercises. MATLAB® is used throughout the text.This book provides a solid basis to practice writing your own codes. The theoretical formulation is complemented by sets of exercises, which allow you to grasp the essence of the modeling tools.

Simulation and modeling using numerical methods is one of the key instruments in any scientific work. In the field of photonics, a wide range of numerical methods are used for studying both fundamental optics and applications such as design, development, and optimization of photonic components. Modeling is key for developing improved photonic devices and reducing development time and cost.Choosing the appropriate computational method for a photonics modeling problem requires a clear understanding of the pros and cons of the available numerical methods. Numerical Methods in Photonics presents six of the most frequently used methods: FDTD, FDFD, 1+1D nonlinear propagation, modal method, Green’s function, and FEM. After an introductory chapter outlining the basics of Maxwell’s equations, the book includes self-contained chapters that focus on each of the methods. Each method is accompanied by a review of the mathematical principles in which it is based, along with sample scripts, illustrative examples of characteristic problem solving, and exercises. MATLAB® is used throughout the text.This book provides a solid basis to practice writing your own codes. The theoretical formulation is complemented by sets of exercises, which allow you to grasp the essence of the modeling tools.

How and why certain proteins misfold and how this misfolding is linked to many disease processes has become a well-documented topic of study. Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols moves beyond the basics to emphasize the molecular effects of protein misfolding at a cellular level, to delineate the impacts and cellular reactions that play a role in pathogenetic mechanisms, and to pinpoint possible manipulations and treatment strategies that can counteract, modify, or delay the consequences of misfolding. The volume begins with several concepts and approaches developed in the recent past including a connection to the research field of aging, where protein misfolding diseases have been equated to premature aging processes, and the book’s coverage continues with detailed descriptions of protocols for relevant experimental approaches. Written in the highly successful Methods in Molecular Biology™ series format, protocols chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols aims to aid researchers in the field, as well as medical professionals and molecular biologists, in shaping and performing research related to this intriguing and vital subject.

A comprehensive review of the latest thinking about the molecular processes underlying conformational diseases, combined with a remarkable set of biochemical, genomic cellular, and chemical laboratory techniques for studying their genesis and pathologies. The authors apply their carefully refined methods to a variety of metabolic and neurodegenerative disorders, as well as to the aging process. The techniques presented are broadly applicable in many diverse disease contexts and may be used in both diagnosis and research on new treatment strategies.

How and why certain proteins misfold and how this misfolding is linked to many disease processes has become a well-documented topic of study. Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols moves beyond the basics to emphasize the molecular effects of protein misfolding at a cellular level, to delineate the impacts and cellular reactions that play a role in pathogenetic mechanisms, and to pinpoint possible manipulations and treatment strategies that can counteract, modify, or delay the consequences of misfolding. The volume begins with several concepts and approaches developed in the recent past including a connection to the research field of aging, where protein misfolding diseases have been equated to premature aging processes, and the book’s coverage continues with detailed descriptions of protocols for relevant experimental approaches. Written in the highly successful Methods in Molecular Biology™ series format, protocols chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols aims to aid researchers in the field, as well as medical professionals and molecular biologists, in shaping and performing research related to this intriguing and vital subject.