P. Jacob III – författare

This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.

The Europaische Akademie Bad Neuenahr-Ahrweiler GmbH is concerned with the scientific study ofthe consequences of scientific and technological advance for the individual, society and the natural environment and, therefore, not least with the study of consequences of recent developments in life-sciences and medical disci- plines. The Europaische Akademie intends to contribute to find a rational way for society to deal with the consequences of scientific progress. This aim is mainly realised by proposing recommendations for options of action with long-term social acceptance. The work of the Europaische Akademie mostly takes place in tempo- rary interdisciplinary project groups, whose members are recognised scientists from European universities and other independent institutes. In the light of recent discussions on the validity of scientific assumptions con- cerning the extrapolation ofharmful effects into the low-dose range the Europais- che Akademie set up a project on "Lew-Dose Exposures in the Environment their Risk Assessments and Regulatory Processes" in January 2001.Experts ofradiobi- ology, toxicology, medical epidemiology, modelling,jurisprudence, psychology and philosophy from different European countries wcre brought together to discuss cur- rent scientific developments in environmental standard setting and risk evaluation of substances and ionising radiation at very low doses in order to ensure rational, efficient, and fair decisions. I am glad that by means ofthis memorandum, that continues our work on envi- ronmental standards and after our recommendations with respect to the regulation ofcombined agents we can now focus on the effects and the regulation ofharmful agents in the very low-dose range.