Paolo Sbraccia – författare

These guidelines make recommendations regarding the managementof individuals with a body mass index greater than 25.0 kg/m2and cover all age groups, from children to the elderly, as well as variouspatient subsets. A range of measures to yield health benefits are set out,including healthy eating plans, increased physical activity, and behavioralmodifications to help patients to manage obesity. In addition, recommendationsare made on the use of bariatric surgery and the new antiobesity drugs.Throughout the process of developing the recommendations, every attempt wasmade to ensure use of a rigorous, evidence-based approach.  The guidelinesare promoted by the Italian Society of Obesity (SIO) and were formulated incompliance with a prespecified process overseen by a steering committee. Theyare intended for use by a wide range of clinicians, including generalpractitioners, primary health care nurses, and primary health careprofessionals, and will hopefully prove of value in combating the obesityepidemic not only in Italy but across Europe and elsewhere in the world.

This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever -increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment. Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.