Patrick A. Lewis – författare

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration.

Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer's disease, Parkinson's, Prion, Motor Neuron, Huntington's, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration.- Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders- Describes the clinical background and underlying molecular processes for Alzheimer''s disease, Parkinson''s, Prion, Motor Neuron, Huntington''s, and Multiple Sclerosis- Highlights the state-of-the-art treatment options for each disorder- Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Playing at War offers an innovative focus on Civil War video games as significant sites of memory creation, distortion, and evolution in popular culture. With fifteen essays by historians, the collection analyzes the emergence and popularity of video games that topically engage the period surrounding the American Civil War, from the earliest console games developed in the 1980s through the web-based games of the twenty-first century, including popular titles such as Red Dead Redemption 2 and War of Rights. Alongside discussions of technological capabilities and advances, as well as their impact on gameplay and content, the essays consider how these games engage with historical scholarship on the Civil War era, the degree to which video games reflect and contribute to popular understandings of the period, and how those dynamics reveal shifting conceptions of martial identity and historical memory within U.S. popular culture. Video games offer productive sites for extending the analysis of Civil War memory into the post Confederates in the Attic era, including the political and cultural moments of Obama and Trump, where overt expressions of Lost Cause memory were challenged and removed from schools and public spaces, then embraced by new manifestations of white supremacist organizations. Edited by Patrick A. Lewis and James Hill Welborn III, Playing at War traces the drift of Civil War memory into digital spaces and gaming cultures, encouraging historians to engage more extensively with video games as important cultural media for examining how contemporary Americans interact with the nation's past.

Playing at War offers an innovative focus on Civil War video games as significant sites of memory creation, distortion, and evolution in popular culture. With fifteen essays by historians, the collection analyzes the emergence and popularity of video games that topically engage the period surrounding the American Civil War, from the earliest console games developed in the 1980s through the web-based games of the twenty-first century, including popular titles such as Red Dead Redemption 2 and War of Rights. Alongside discussions of technological capabilities and advances, as well as their impact on gameplay and content, the essays consider how these games engage with historical scholarship on the Civil War era, the degree to which video games reflect and contribute to popular understandings of the period, and how those dynamics reveal shifting conceptions of martial identity and historical memory within U.S. popular culture. Video games offer productive sites for extending the analysis of Civil War memory into the post Confederates in the Attic era, including the political and cultural moments of Obama and Trump, where overt expressions of Lost Cause memory were challenged and removed from schools and public spaces, then embraced by new manifestations of white supremacist organizations. Edited by Patrick A. Lewis and James Hill Welborn III, Playing at War traces the drift of Civil War memory into digital spaces and gaming cultures, encouraging historians to engage more extensively with video games as important cultural media for examining how contemporary Americans interact with the nation's past.

Benjamin Forsythe Buckner (1836--1901) faced a dire choice as the flames of Civil War threatened his native Kentucky. As an ambitious Bluegrass aristocrat, he was sympathetic to fellow slave owners, but was also convinced that the Peculiar Institution could not survive a war for southern independence. Defying the wishes of his Rebel fiancée and her powerful family -- yet still hoping to impress them with his resolve, independence, and courage -- Buckner joined the 20th Kentucky Volunteer Infantry in 1861 as a Union soldier. President Abraham Lincoln's Emancipation Proclamation ultimately destroyed Buckner's faith in his cause, however, and he resigned his commission.In this groundbreaking biography, author Patrick A. Lewis uses Buckner's story to illuminate the origins and perspectives of Kentucky's conservative proslavery Unionists and explain why this group became a key force in repressing social and political change during the Reconstruction era and beyond. While other studies have explored how this former Union state cultivated a Confederate identity after the Civil War, For Slavery and Union is the first major work to personify this transformation. Lewis's book provides a deeply nuanced look at the history of the Commonwealth in the nineteenth century and the development of the New South.

Benjamin Forsythe Buckner (18361901) faced a dire choice as the flames of Civil War threatened his native Kentucky. As an ambitious Bluegrass aristocrat, he was sympathetic to fellow slave owners, but was also convinced that the Peculiar Institution could not survive a war for southern independence. Defying the wishes of his Rebel fiance and her powerful familyyet still hoping to impress them with his resolve, independence, and courageBuckner joined the 20th Kentucky Volunteer Infantry in 1861 as a Union soldier. President Abraham Lincoln's Emancipation Proclamation ultimately destroyed Buckner's faith in his cause, however, and he resigned his commission.In this groundbreaking biography, author Patrick A. Lewis uses Buckner's story to illuminate the origins and perspectives of Kentucky's conservative proslavery Unionists and explain why this group became a key force in repressing social and political change during the Reconstruction era and beyond. While other studies have explored how this former Union state cultivated a Confederate identity after the Civil War, For Slavery and Union is the first major work to personify this transformation. Lewis's book provides a deeply nuanced look at the history of the Commonwealth in the nineteenth century and the development of the New South.

Benjamin Forsythe Buckner (1836-1901) faced a dire choice as the flames of Civil War threatened his native Kentucky. As an ambitious Bluegrass aristocrat, he was sympathetic to fellow slave owners, but was also convinced that the Peculiar Institution could not survive a war for southern independence. Defying the wishes of his Rebel fiancee and her powerful family-yet still hoping to impress them with his resolve, independence, and courage-Buckner joined the 20th Kentucky Volunteer Infantry in 1861 as a Union soldier. President Abraham Lincoln's Emancipation Proclamation ultimately destroyed Buckner's faith in his cause, however, and he resigned his commission.In this groundbreaking biography, author Patrick A. Lewis uses Buckner's story to illuminate the origins and perspectives of Kentucky's conservative proslavery Unionists and explain why this group became a key force in repressing social and political change during the Reconstruction era and beyond. While other studies have explored how this former Union state cultivated a Confederate identity after the Civil War, For Slavery and Union is the first major work to personify this transformation. Lewis's book provides a deeply nuanced look at the history of the Commonwealth in the nineteenth century and the development of the New South.