Paul Brennan - Böcker

Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.

A rare and ancient manuscript, saved from destruction and hidden since colonial times, is discovered in the basement of the British Library. A secret that links two great chefs, separated from each other by 250 years. Wrenched from a nation at war, the manuscript’s original owner escapes death and takes flight by river to an old Siamese trading port, hundreds of miles away. In the company of an opium- and gin-crazed Dutch ship’s captain, he begins a sea voyage through vibrant coastal towns and violent storms, leading not to his freedom but to cruel betrayal by those in whom he has placed his trust. When the manuscript’s new owner realises what she has discovered, she returns with it to modern-day Thailand, awakening long-dormant ancient spirits. But when the manuscript escapes Siam once more, a new trail of destruction is created in its wake. How far would you go to own the Imperial secrets?