Paul S. Agutter – författare

Thanks to the popular media, and to books by Dawkins, Fortey, Gould, Margulis and other writers, people are informed about many aspects of biology. Everyone seems to know a little about evolution, for example, and about DNA and the possibilities (good and bad) afforded by research in molecular genetics. Most people know some of the arguments for and against the likelihood of life on other planets. And so on. We are glad that these pieces of information have become so widely available. However, we do not assume any particular knowledge (other than the most basic) in this book. Our aim is to address general questions rather than specific issues. We want to enable our readers to join their disparate pieces of knowledge about biology together. The most basic of these general questions – and perhaps the most difficult – can be expressed in beguilingly simple words: “What is life”? What does modern biology tell us about the essential differences between living organisms and the inanimate world? An attempt to answer this question takes us on a journey through almost the whole of contemporary cell and molecular biology, which occupies the first half of the book. The journey is worth the effort. The provisional answer we attain provides a coherent, unifying context in which we can discuss evolution, the origin of life, extraterrestrial life, the meaning of “intelligence”, the evolution of the human brain and the nature of mind.

What we now call ‘deep venous thrombosis’ (DVT) has been studied in diverse ways during the last 200–300 years. Each of these approaches contributes to a full modern understanding of aetiology. Therefore, much of this book is a historical survey of the field. However, our remit is broader than the title might suggest: the evolution of ideas about DVT is typical in many ways of medical biology as a whole. Thus, although the aetiology of DVT may seem a narrow topic for a monograph – it implicitly excludes arterial thrombosis and marginalises prophylaxis, therapy, and even such clinically significant sequelae as pulmonary embolism – we hope to engage the reader in a much more general inquiry. Our historical investigation reveals a 160-year-old schism between two contrasting philosophies of medical and biological research, a schism that is particularly – but by no means uniquely – relevant to the study of DVT. In principle, these philosophies should be complementary rather than competing. So while we wish to elucidate the aetiology of DVT per se, we are also concerned with a more abstract and wide-ranging issue: the future accommodation or rapprochement between two conceptual and methodological traditions.

Our previous book, About Life, concerned modern biology. We used our present-day understanding of cells to ‘define’ the living state, providing a basis for exploring several general-interest topics: the origin of life, extraterrestrial life, intelligence, and the possibility that humans are unique. The ideas we proposed in About Life were intended as starting-points for debate – we did not claim them as ‘truth’ – but the information on which they were based is currently accepted as ‘scientific fact’. What does that mean? What is ‘scientific fact’ and why is it accepted? What is science – and is biology like other sciences such as physics (except in subject m- ter)? The book you are now reading investigates these questions – and some related ones. Like About Life, it may particularly interest a reader who wishes to change career to biology and its related subdisciplines. In line with a recommendation by the British Association for the Advancement of Science – that the public should be given fuller information about the nature of science – we present the concepts underpinning biology and a survey of its historical and philosophical basis.

The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.

Thanks to the popular media, and to books by Dawkins, Fortey, Gould, Margulis and other writers, people are informed about many aspects of biology. Everyone seems to know a little about evolution, for example, and about DNA and the possibilities (good and bad) afforded by research in molecular genetics. Most people know some of the arguments for and against the likelihood of life on other planets. And so on. We are glad that these pieces of information have become so widely available. However, we do not assume any particular knowledge (other than the most basic) in this book. Our aim is to address general questions rather than specific issues. We want to enable our readers to join their disparate pieces of knowledge about biology together. The most basic of these general questions – and perhaps the most difficult – can be expressed in beguilingly simple words: “What is life”? What does modern biology tell us about the essential differences between living organisms and the inanimate world? An attempt to answer this question takes us on a journey through almost the whole of contemporary cell and molecular biology, which occupies the first half of the book. The journey is worth the effort. The provisional answer we attain provides a coherent, unifying context in which we can discuss evolution, the origin of life, extraterrestrial life, the meaning of “intelligence”, the evolution of the human brain and the nature of mind.

What we now call 'deep venous thrombosis' (DVT) has been elucidated by a diversity of investigative approaches during the past four centuries. The authors of this book survey the history of the field and ask: why has one of these perspectives -- the haematological/biochemical -- come to dominate research into the causation of DVT during the past 50 years and to exclude alternatives? In answering this question, the authors show that the current consensus model is conceptually flawed.