Pei Hui – författare

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations.

Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.

Gestational trophoblastic disease (GTD) is a distinct category of human disorders of placental trophoblast, resulting in significant morbidities in women. It is notable for its varying geographical distribution and different frequencies across age groups. In human pathology, GTD represents unique proliferative conditions of the trophoblast, characterized by distinct clinical presentations, genetic compositions, and varying biological behaviors. Since the first edition of this book, substantial new knowledge has emerged regarding the pathogenesis, diagnostic pathology, and therapeutic interventions for GTD, necessitating an update. This second edition will incorporate these advancements, focusing on key themes such as the current understanding of the molecular pathogenesis of gestational trophoblastic disease, new classifications and disease entities introduced by the WHO, refined diagnostic criteria, recent immunohistochemical biomarkers for both diagnostic and therapeutic applications, molecular genotyping analysis of GTD, and novel clinical therapeutic interventions, including modern immunotherapy for patients with high-risk gestational trophoblastic neoplasms.

Like the first edition, this comprehensive book emphasizes diagnostic pathology and the genetic aspects of the disease. The second edition will feature an enriched collection of diagnostically challenging cases of trophoblastic specimens curated from the author’s personal consultation practice over the past decade. Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology, 2nd Edition is written for a broad audience in diagnostic pathology, including specialty gynecologic pathologists, general pathologists, molecular pathologists, and pathologists-in-training.

Contributions from leading experts offer diverse perspectives and valuable insights, making this text a robust resource for pathologists, clinicians, and researchers navigating the complexities of GTD. The book is ideal for organizing diagnostic pathology training courses on gestational trophoblastic disease. It also serves as a valuable reference for scientific investigators interested in trophoblastic disorders and the genetic/epigenetic regulation of placental trophoblast development and function.

As new discoveries continue to reshape our understanding of GTD, we hope this edition serves as a bridge between current knowledge and future innovations, offering both a practical guide and an inspiring resource for advancing GTD diagnosis, treatment and research.

This atlas is dedicated specifically to gynecologic frozen section diagnosis and addresses professional practice gaps such as high diagnostic error rate, slow turnaround time, and inefficient communication between surgeons and pathologists at the time of intraoperative frozen section consultation of gynecologic specimens. The format of the volume is a combination of concise text and high quality gross and frozen section microscopic images, meticulously selected from the superb collection of pathology specimens of gynecologic tumors provided at Yale-New Haven Hospital in the past decades. Frequent entities with diagnostic pitfalls are balanced with less common lesions. Strategies to recognize their diagnostic features are emphasized, in addition to the impact on optimal surgical treatment of patients with gynecologic cancer. The indications, limitations, morphologic diagnostic criteria and pitfalls of frozen section consultation in gynecologic pathology are thoroughly reviewed with an ultimate goal of avoiding patient mismanagement in real-time. High quality frozen section microscopic illustrations aid the recognition of morphologic patterns and serve as quick reference during intraoperative consultation.       Written by experts in the field, Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology is a valuable resource for pathologists at all career/expertise levels who are involved in intraoperative consultation in their daily clinical practice.