Pei Hui - Böcker

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations.Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.

With a unique emphasis on the correlation between cytology and surgical pathology, Cytology and Surgical Pathology of Gynecologic Neoplasms provides a ready reference for both the practicing pathologist and pathologist in training in finding quick answers to their diagnostic challenges.

The neoplasms found in the female genital tract are numerous and growing more complex. Cytology and Surgical Pathology of Gynecologic Neoplasms has been written to provide a practical reference for practicing pathologists and cytopathologists in a quick and concise fashion. The primary focus of this book is on gynecological tumors, specifically common ones and their benign mimics. Emphasis is placed on morphologic recognition, resolving common diagnostic problems seen in routine practices, and discussion of current classification of gynecologic malignancies. Special references to the differential diagnosis and pitfalls of each entity are included. The role of cytology and its correlation with histology is richly illustrated and discussed. Also presented is the practical use of ancillary studies such as molecular diagnostic testing and immunohistochemistry.With a unique emphasis on the correlation between cytology and surgical pathology, Cytology and Surgical Pathology of Gynecologic Neoplasms provides a ready reference for both the practicing pathologist and pathologist in training in finding quick answers to their diagnostic challenges.

This book serves as a quick review or summary of major diagnostic challenges in gynecologic pathology and embraces a Q/A format by providing the desired diagnostic knowledge.

This book serves as a quick review or summary of major diagnostic challenges in gynecologic pathology and embraces a Q/A format by providing the desired diagnostic knowledge.

Gestational trophoblastic disease (GTD) is a distinct category of human disorders of placental trophoblast, resulting in significant morbidities in women. It is notable for its varying geographical distribution and different frequencies across age groups. In human pathology, GTD represents unique proliferative conditions of the trophoblast, characterized by distinct clinical presentations, genetic compositions, and varying biological behaviors. Since the first edition of this book, substantial new knowledge has emerged regarding the pathogenesis, diagnostic pathology, and therapeutic interventions for GTD, necessitating an update. This second edition will incorporate these advancements, focusing on key themes such as the current understanding of the molecular pathogenesis of gestational trophoblastic disease, new classifications and disease entities introduced by the WHO, refined diagnostic criteria, recent immunohistochemical biomarkers for both diagnostic and therapeutic applications, molecular genotyping analysis of GTD, and novel clinical therapeutic interventions, including modern immunotherapy for patients with high-risk gestational trophoblastic neoplasms.Like the first edition, this comprehensive book emphasizes diagnostic pathology and the genetic aspects of the disease. The second edition will feature an enriched collection of diagnostically challenging cases of trophoblastic specimens curated from the author’s personal consultation practice over the past decade. Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology, 2nd Edition is written for a broad audience in diagnostic pathology, including specialty gynecologic pathologists, general pathologists, molecular pathologists, and pathologists-in-training.Contributions from leading experts offer diverse perspectives and valuable insights, making this text a robust resource for pathologists, clinicians, and researchers navigating the complexities of GTD. The book is ideal for organizing diagnostic pathology training courses on gestational trophoblastic disease. It also serves as a valuable reference for scientific investigators interested in trophoblastic disorders and the genetic/epigenetic regulation of placental trophoblast development and function.As new discoveries continue to reshape our understanding of GTD, we hope this edition serves as a bridge between current knowledge and future innovations, offering both a practical guide and an inspiring resource for advancing GTD diagnosis, treatment and research.

This atlas is dedicated specifically to gynecologic frozen section diagnosis and addresses professional practice gaps such as high diagnostic error rate, slow turnaround time, and inefficient communication between surgeons and pathologists at the time of intraoperative frozen section consultation of gynecologic specimens.