Peng Chen - Böcker

Computational Intelligence in Protein-Ligand Interaction Analysis presents computational techniques for predicting protein-ligand interactions, recognizing protein interaction sites, and identifying protein drug targets. The book emphasizes novel approaches to protein-ligand interactions, including machine learning and deep learning, presenting a state-of-the-art suite of skills for researchers. The volume represents a resource for scientists, detailing the fundamentals of computational methods, showing how to use computational algorithms to study protein interaction data, and giving scientific explanations for biological data through computational intelligence. Fourteen chapters offer a comprehensive guide to protein interaction data and computational intelligence methods for protein-ligand interactions. Presents a guide to computational techniques for protein-ligand interaction analysis Guides researchers in developing advanced computational intelligence methods for the protein-ligand problem Identifies appropriate computational tools for various problems Demonstrates the use of advanced techniques such as vector machine, neural networks, and machine learning Offers the computational, mathematical and statistical skills researchers need

Extremal Optimization: Fundamentals, Algorithms, and Applications introduces state-of-the-art extremal optimization (EO) and modified EO (MEO) solutions from fundamentals, methodologies, and algorithms to applications based on numerous classic publications and the authors’ recent original research results. It promotes the movement of EO from academic study to practical applications. The book covers four aspects, beginning with a general review of real-world optimization problems and popular solutions with a focus on computational complexity, such as "NP-hard" and the "phase transitions" occurring on the search landscape.Next, it introduces computational extremal dynamics and its applications in EO from principles, mechanisms, and algorithms to the experiments on some benchmark problems such as TSP, spin glass, Max-SAT (maximum satisfiability), and graph partition. It then presents studies on the fundamental features of search dynamics and mechanisms in EO with a focus on self-organized optimization, evolutionary probability distribution, and structure features (e.g., backbones), which are based on the authors’ recent research results. Finally, it discusses applications of EO and MEO in multiobjective optimization, systems modeling, intelligent control, and production scheduling.The authors present the advanced features of EO in solving NP-hard problems through problem formulation, algorithms, and simulation studies on popular benchmarks and industrial applications. They also focus on the development of MEO and its applications. This book can be used as a reference for graduate students, research developers, and practical engineers who work on developing optimization solutions for those complex systems with hardness that cannot be solved with mathematical optimization or other computational intelligence, such as evolutionary computations.

Extremal Optimization: Fundamentals, Algorithms, and Applications introduces state-of-the-art extremal optimization (EO) and modified EO (MEO) solutions from fundamentals, methodologies, and algorithms to applications based on numerous classic publications and the authors’ recent original research results. It promotes the movement of EO from academic study to practical applications. The book covers four aspects, beginning with a general review of real-world optimization problems and popular solutions with a focus on computational complexity, such as "NP-hard" and the "phase transitions" occurring on the search landscape.Next, it introduces computational extremal dynamics and its applications in EO from principles, mechanisms, and algorithms to the experiments on some benchmark problems such as TSP, spin glass, Max-SAT (maximum satisfiability), and graph partition. It then presents studies on the fundamental features of search dynamics and mechanisms in EO with a focus on self-organized optimization, evolutionary probability distribution, and structure features (e.g., backbones), which are based on the authors’ recent research results. Finally, it discusses applications of EO and MEO in multiobjective optimization, systems modeling, intelligent control, and production scheduling.The authors present the advanced features of EO in solving NP-hard problems through problem formulation, algorithms, and simulation studies on popular benchmarks and industrial applications. They also focus on the development of MEO and its applications. This book can be used as a reference for graduate students, research developers, and practical engineers who work on developing optimization solutions for those complex systems with hardness that cannot be solved with mathematical optimization or other computational intelligence, such as evolutionary computations.

This book aims to introduce the latest research in gut microbiota by systematically summarizing how it modulates the pathogenesis of organ injury including alimentary tract injury, liver injury, lung injury, brain injury, renal injury, heart and vascular injury, endocrine disorders, immune responses and multiple organ dysfunction syndrome (MODS) during sepsis. Gut microbiota which is recognized as a new “organ” in the body has been demonstrated to be able to regulate the homeostasis of many organs. The key role played by gut microbiota is the hotspot in biomedical research nowadays. This book provides a state-of-the-art report on recent discoveries regarding the novel insight into the mechanisms of human diseases progression. It will also offer the overall picture of the pathophysiologic roles of gut microbiota. This book is helpful for graduate students and professional researchers to get the knowledge of frontiers in both gut microbiota and organ injury.