Peter Brenner – författare

Morbus Dupuytren is particularly widespread among northern Europeans. However, the therapeutic success-rate often leaves much to be desired. A 50 per cent recurrence-rate after surgery indicates that the disease cannot be treated by surgery alone. This book therefore adopts two parallel approaches: emphasis is firstly placed on the systemic character of morbus Dupuytren in context with other connective tissue diseases by a description of the biochemical and molecular-biological changes in the diseased connective tissues; secondly, a diversified picture of the given anatomical facts serves to explain the employment of the various therapeutic approaches. Further, a description is given of the current surgical procedures.

In this volume a distinguished group of internationallyrenowned clinicians and basic researchers discuss thepresent state of knowledge of the etiologyand pathogenesisof Dupuytren's contracture, a disease responsible for aconsiderable portion of disabilities within the workingpopulation allover the world. Although the riddle of howthe contracture of the palmar fascia develops is stillunsolved, the data on the pathobiochemistry and clinic ofDupuytren's Disease achieved in recent years has led to abetter understanding of the biochemical and morphologicalprocesses underlying the deformation and malfunction of theafflicted tissues. Research in Dupuytren's Disease nowenters the era of molecular medicine, which opens up newexperimental means of studying the pathological changeswhich occur during the formation of the contracture on amolecular level. In particular, data are presented as to therole of specific biological macromolecules influencing thephenotype expression of the palmar fascia cells which areinvolved in autoimmune reactions and present both at thecell surface as well as in the extracellular matrix toregulate cell-to-cell and cell-to-matrix interactions. Invitro cell culture models to investigate fibro-cyticmodulations are available and havebeen applied to study theeffects of specific biological molecules on isolated cellsfrom healthy palmar fascia and Dupuytren's contracture.Complementary evaluations of morphological, epidemiological,and clinical data contribute essentially to the presentunderstanding of the etiology and pathogenesis ofDupuytren's Disease. This comprehensive and informativesummary of the state of the art is completed by numerousreferences affixed to the individual contributions.

In this volume a distinguished group of internationallyrenowned clinicians and basic researchers discuss thepresent state of knowledge of the etiologyand pathogenesisof Dupuytren''s contracture, a disease responsible for aconsiderable portion of disabilities within the workingpopulation allover the world. Although the riddle of howthe contracture of the palmar fascia develops is stillunsolved, the data on the pathobiochemistry and clinic ofDupuytren''s Disease achieved in recent years has led to abetter understanding of the biochemical and morphologicalprocesses underlying the deformation and malfunction of theafflicted tissues. Research in Dupuytren''s Disease nowenters the era of molecular medicine, which opens up newexperimental means of studying the pathological changeswhich occur during the formation of the contracture on amolecular level. In particular, data are presented as to therole of specific biological macromolecules influencing thephenotype expression of the palmar fascia cells which areinvolved in autoimmune reactions and present both at thecell surface as well as in the extracellular matrix toregulate cell-to-cell and cell-to-matrix interactions. Invitro cell culture models to investigate fibro-cyticmodulations are available and havebeen applied to study theeffects of specific biological molecules on isolated cellsfrom healthy palmar fascia and Dupuytren''s contracture.Complementary evaluations of morphological, epidemiological,and clinical data contribute essentially to the presentunderstanding of the etiology and pathogenesis ofDupuytren''s Disease. This comprehensive and informativesummary of the state of the art is completed by numerousreferences affixed to the individual contributions.

Morbus Dupuytren is particularly widespread among northern Europeans. However, the therapeutic success-rate often leaves much to be desired. A 50% recurrence-rate after surgery indicates that the disease cannot be treated by surgery alone. This book therefore adopts two parallel approaches: emphasis is firstly placed on the systemic character of morbus Dupuytren in context with other connective tissue diseases by a description of the biochemical and molecular-biological changes in the diseased connective tissues; secondly, a diversified picture of the given anatomical facts serves to explain the employment of the various therapeutic approaches. Further, a description is given of the current surgical procedures.

1,9 Millionen Deutsche sind vom Morbus Dupuytren betroffen. Eine Rezidivrate von über 50% nach chirurgischen Therapieversuchen zeigt, dass die Erkrankung nicht ausschließlich chirurgisch behandelbar ist. In diesem Werk werden daher zwei Wege eingeschlagen: Einerseits wird durch eine Beschreibung der biochemischen und molekularbiologischen Veränderungen des erkrankten Bindegewebes der systemische Charakter des Morbus Dupuytren im Kontext mit anderen Bindegewebserkrankungen hervorgehoben. Andererseits werden die unterschiedlichen therapeutischen Ansätze aus einer differenzierten Darstellung der anatomischen Gegebenheiten hergeleitet. Neben den Grundzügen konservativer Therapie werden alle gängigen chirurgischen Verfahren inklusive verfahrensspezifischer Komplikationen beschrieben sowie zeichnerisch in ihren wesentlichen Zügen vorgestellt. Das Buch wendet sich an alle, die eine aktuelle Übersicht zum Morbus Dupuytren wünschen und über die etablierten Therapiekonzepte instruktiv unterrichtet werden wollen.

1,9 Millionen Deutsche sind vom Morbus Dupuytren betroffen. Eine Rezidivrate von über 50% nach chirurgischen Therapieversuchen zeigt, dass die Erkrankung nicht ausschließlich chirurgisch behandelbar ist. In diesem Werk werden daher zwei Wege eingeschlagen: Einerseits wird durch eine Beschreibung der biochemischen und molekularbiologischen Veränderungen des erkrankten Bindegewebes der systemische Charakter des Morbus Dupuytren im Kontext mit anderen Bindegewebserkrankungen hervorgehoben. Andererseits werden die unterschiedlichen therapeutischen Ansätze aus einer differenzierten Darstellung der anatomischen Gegebenheiten hergeleitet. Neben den Grundzügen konservativer Therapie werden alle gängigen chirurgischen Verfahren inklusive verfahrensspezifischer Komplikationen beschrieben sowie zeichnerisch in ihren wesentlichen Zügen vorgestellt. Das Buch wendet sich an alle, die eine aktuelle Übersicht zum Morbus Dupuytren wünschen und über die etablierten Therapiekonzepte instruktiv unterrichtet werden wollen.

InhaltsverzeichnisKapitel 1: Die Vorteile vom Anbau eigener NahrungsmittelKapitel 2: Wie Sie Essen anbauen ohne eigenen GartenKapitel 3: Was für die AnfängerKapitel 4: Nahrungsmittel für das kleine BudgetKapitel 5: Möglichkeiten Ihre Ernte zu lagernKapitel 6: Tipps für den Kauf von Samen und PflanzenKapitel 7: Tipps zur Erhaltung Ihrer ErnteKapitel 8: 5 Wege die Beste Ernte zu erhaltenKapitel 9: Berechnung des erforderlichen PlatzesKapitel 10: 5 Tipps zur voraus Planung