Peter Manu – författare

Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects.

Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness Discusses clozapine rechallenge after each of its serious adverse reactions Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy Includes data on post-mortem considerations

Functional somatic syndromes are defined as physical syndromes without an organic disease explanation, demonstrable structural changes, or established biochemical abnormalities. This book reviews the state of scientific and clinical understanding of the nine most common functional somatic syndromes. For each syndrome, expert authors provide a brief historical perspective, a current definition, a case presentation, confirmatory and contradictory research findings, a discussion of the leading pathogenetic hypotheses, and guidelines for diagnosis and treatment. Advice is given for the determination of disability of patients with these medically unexplained disorders, and both medical and psychiatric interventions are described. Stressing the importance of a sound therapeutic relationship as a basis for treatment, this is an invaluable resource for professionals in primary care and many other disciplines.

Functional somatic syndromes are defined as physical syndromes without an organic disease explanation, demonstrable structural changes, or established biochemical abnormalities. This book reviews the state of scientific and clinical understanding of the nine most common functional somatic syndromes. For each syndrome, expert authors provide a brief historical perspective, a current definition, a case presentation, confirmatory and contradictory research findings, a discussion of the leading pathogenetic hypotheses, and guidelines for diagnosis and treatment. Advice is given for the determination of disability of patients with these medically unexplained disorders, and both medical and psychiatric interventions are described. Stressing the importance of a sound therapeutic relationship as a basis for treatment, this is an invaluable resource for professionals in primary care and many other disciplines.

Learn how a patient’s behavior can factor into the prognosis of medically unexplainable illness! The Psychopathology of Functional Somatic Syndromes examines the link between mental illness and physical syndromes that lack organic disease explanations, including chronic fatigue syndrome, fibromyalgia, premenstrual dysphoria, irritable bowel, and Gulf War illness. The author has evaluated the best research work of the past 20 years to determine the association between psychopathology and functional illness, the biological gradient between somatic and psychological symptoms, and the manifestations of dysfunctional coping. The Psychopathology of Functional Somatic Syndromes challenges recent conceptualizations of functional somatic syndromes as brain disorders connected to affective spectrum disorder, serotonin deficiency, cerebral hypoperfusion or abnormal hypothalamic-pituitary-adrenal function and highlights the importance of abnormal illness behavior, sexual victimization, and maladaptive coping for the production and maintenance of these disorders. The Psychopathology of Functional Somatic Syndromes explores observations on the neurobiology and the personality abnormalities of patients made from structured data collected over a period of several years. It describes modern perceptions of functional somatic syndromes and how they have evolved into a tightly knit family of self-standing syndromes with a common core. The book examines the correlation between the burden of psychopathology and the physical features of these illnesses; reviews advances made in the appraisal of the neuroanatomy, neuropsychology, and neurochemistry of functional syndromes; and focuses on the connection between measurable dimensions of personality, coping, and illness behavior and the prognosis of medically unexplainable illnesses. The Psychopathology of Functional Somatic Syndromes examines:psychiatric morbidity brain perfusion post-traumatic stress in Gulf War illness the spectrum of mood disorders the hypothalamatic-pituitary-adrenal axis the sexual victimization of patients and much more! The Psychopathology of Functional Somatic Syndromes is an essential resource for psychiatrists and psychologists working in outpatient practice.

Poverty, substandard medical care, social neglect or withdrawal, unhealthy lifestyle -- these are just some of the contributors to the substantial morbidity of patients with severe mental illness. Medical deteriorations are often unexpected and severe, and particularly difficult to evaluate in the context of psychotic disorders.The Handbook of Medicine in Psychiatry, third edition has been updated and streamlined to provide a commonsense approach to the realities confronting clinicians as it helps them answer whether their patient: • Is at risk of dying or becoming severely disabled.• Requires an immediate therapeutic intervention for a potentially life-threatening condition.• Needs to be transferred to an emergency medicine setting.• Requires urgent investigations.• Must have changes made in the current medication regimen. Clinical vignettes for each chapter illustrate the complexity of the presentation of abnormal vital signs and somatic disorders in psychiatric settings, including fever, hypertension, seizures, and nausea and vomiting.The guide also provides risk stratification for major complications -- from abnormal thyroid function and acute kidney injury to myocarditis and venous thromboembolism -- enabling readers to determine the need for a transfer of the patient to an emergency medicine setting.A brand-new section features thorough discussions of topics requiring interdisciplinary collaboration with geriatricians, neurologists, anesthesiologists, and addiction medicine and adolescent medicine specialists.Clinicians working in today's busy inpatient and outpatient psychiatric settings will find in these pages a cognitive framework and knowledge base that will aid them in accurate decision making in the conditions of uncertainty created by potentially major medical deteriorations of the vulnerable populations under their care.