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This comprehensive title covers all of the broad aspects of stiff-person spectrum disorders (SPSD), ranging from clinical features and laboratory investigations to the basic scientific roles of neuroimmunology and genetics that aid clinicians in understanding the pathogenesis of this disorder.

Organized across 15 chapters, this highly practical book begins with a thorough account of the history and clinical phenomenology of SPSD.  Subsequent chapters then delve into the differential diagnoses of the disorder, as well as its electrophysiology, immunopathogenesis, and neurochemistry. Following this is an analysis of each subtype of SPSD including classic stiff-person syndrome and its variants, correlations between clinical phenotypes and antibodies, as well as SPSD in the pediatric population. Finally, the book concludes with an examination of the various SPSD diagnostic approaches, treatments, and potential emergencies seen in clinical practice.

Developed by a renowned multidisciplinary authorship, Stiff-Person Syndrome and Related Disorders is an indispensable contribution to the clinical literature and will be of great interest to both clinicians and basic science researchers.

This practical, case-based book offers an approach to diagnosis and treatment of movement disorders in the outpatient setting. The major hypokinetic and hyperkinetic disorders are considered in turn, with more than 1,000 videos illustrating the role of phenomenology in the diagnosis and treatment of these conditions. Discussion of the role of ancillary testing (imaging, genetic testing) and treatment options with medications, botulinum toxin injections, and surgical intervention are woven in to the discussion of cases throughout the book. Special attention is directed to pitfalls and perils of office-based practice.