Pierre-Andre Cazenave – författare
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3 produkter
3 produkter
E-bok
PDF, Engelska, 20121 408 kr
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Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine~hat enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti-idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility.
Häftad, Engelska, 2011
1 123 kr
Skickas inom 10-15 vardagar
Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine~hat enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti-idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility.
E-bok
PDF, Engelska, 2013756 kr
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Idiotypy in Biology and Medicine aims to serve the increasing interest and involvement in the practical aspects of idiotypy in biological systems. The concept of idiotypy has received wide recognition and interest far beyond the area of immunology. Experiments and interpretation of findings, reported here, clearly support the general nature of the idiotype concept in manipulating biological systems to correct pathological conditions or to improve the immune adaptation to environmental factors. The book is organized into three sections. Section 1 discusses original concepts of idiotypic manipulations. It reviews old and recent data important for the concept of an idiotype network and reports on attempts to deal with the T-cell receptor paradox; explains the immune system in terms of a circular idiotype network that can be demonstrated by sequential immunization; and emphasizes the need for restrictions in network interactions. Section 2 addresses the role and activity of idiotypic and antiidiotypic antibodies in the regulation of the immune system. Section 3 takes the issue of idiotype-antiidiotype out of the realm of the immune system and discusses it as a new principle to analyze and manipulate biological systems in general.