Prakash Kulkarni – författare

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more.

This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast.

Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more.This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast.- Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity- Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies- Features a diverse range of chapter contributions from international leaders in the field

Over the centuries, civilization has seen considerable advances in healthcare. Cancer is among the most challenging healthcare issues that we face today, but a number of discoveries have led to better care. Despite all the progress and the promise regarding early detection and precision medicine, we are still faced with the nettlesome problem - cancer is a moving target. Even within an individual tumour, deep sequencing analyses now indicate multiple, phenotypically distinct subpopulations, whose representation seems to vary dramatically from one stage to the next as the tumour progresses.Cancer Systems Biology provides state-of-the-art reviews and thought-provoking ideas in a concise and succinct manner. This insightful textbook is a crosspollination of concepts from multiple disciplines and experimental approaches to study cancer. The chapters provide new ideas and thoughts outlining how a quantitative picture of cancer can provide a deeper understanding of the disease, and how a systems level perspective may hold the key to fully comprehend how cancer arises and progresses. Written by experts in multiple disciplines, including systems biologists, science researchers, physicists, mathematicians, and clinicians, Cancer Systems Biology provides a comprehensive, up-to-date, treatise devoted to understanding cancer from a systems perspective. Providing new conceptual insights that can aid precision medicine, it will be essential reading for academic researchers in the field, clinicians, graduate students, and scientists with an interest in cancer biology.

Over the centuries, civilization has seen considerable advances in healthcare. Cancer is among the most challenging healthcare issues that we face today, but a number of discoveries have led to better care. Despite all the progress and the promise regarding early detection and precision medicine, we are still faced with the nettlesome problem - cancer is a moving target. Even within an individual tumour, deep sequencing analyses now indicate multiple, phenotypically distinct subpopulations, whose representation seems to vary dramatically from one stage to the next as the tumour progresses.Cancer Systems Biology provides state-of-the-art reviews and thought-provoking ideas in a concise and succinct manner. This insightful textbook is a crosspollination of concepts from multiple disciplines and experimental approaches to study cancer. The chapters provide new ideas and thoughts outlining how a quantitative picture of cancer can provide a deeper understanding of the disease, and how a systems level perspective may hold the key to fully comprehend how cancer arises and progresses. Written by experts in multiple disciplines, including systems biologists, science researchers, physicists, mathematicians, and clinicians, Cancer Systems Biology provides a comprehensive, up-to-date, treatise devoted to understanding cancer from a systems perspective. Providing new conceptual insights that can aid precision medicine, it will be essential reading for academic researchers in the field, clinicians, graduate students, and scientists with an interest in cancer biology.

Over the centuries, civilization has seen considerable advances in healthcare. Cancer is among the most challenging healthcare issues that we face today, but a number of discoveries have led to better care. Despite all the progress and the promise regarding early detection and precision medicine, we are still faced with the nettlesome problem - cancer is a moving target. Even within an individual tumour, deep sequencing analyses now indicate multiple, phenotypically distinct subpopulations, whose representation seems to vary dramatically from one stage to the next as the tumour progresses.Cancer Systems Biology provides state-of-the-art reviews and thought-provoking ideas in a concise and succinct manner. This insightful textbook is a crosspollination of concepts from multiple disciplines and experimental approaches to study cancer. The chapters provide new ideas and thoughts outlining how a quantitative picture of cancer can provide a deeper understanding of the disease, and how a systems level perspective may hold the key to fully comprehend how cancer arises and progresses. Written by experts in multiple disciplines, including systems biologists, science researchers, physicists, mathematicians, and clinicians, Cancer Systems Biology provides a comprehensive, up-to-date, treatise devoted to understanding cancer from a systems perspective. Providing new conceptual insights that can aid precision medicine, it will be essential reading for academic researchers in the field, clinicians, graduate students, and scientists with an interest in cancer biology.

This book covers state-of-the-art immunotherapeutic modalities also discusses how phenotypic plasticity of cancer cells plays a crucial role in the emergence of immune resistance.  Targeting both medical oncologists and basic cancer researchers, this book fills a crucial gap by emphasizing the importance of a team medicine approach that integrates major medical centers and the clinical practices in their network. The goals are to educate professionals on the importance of an integrated approach to enhance the quality of research and patient care in oncology. This work stands out as an essential resource to the community challenged with integrating basic and translational research, along with clinical medicine in academic centers and their clinical networks worldwide. Authored by world-renowned experts in the field, this book fills a significant gap in the literature by focusing specifically on integrating the experience and expertise of basic scientists and clinicians both in academic centers and the oncology hospitals in their clinical network.